STK11 antibody

Principal name

STK11 antibody

Alternative names for STK11 antibody

Serine/threonine-protein kinase 11, LKB1, PJS, NY-REN-19, Serine/threonine-protein kinase LKB1, Renal carcinoma antigen NY-REN-19

SwissProt ID

Q0GGW5 (Chick), Q15831 (Human), Q91604 (Xenla), Q9WTK7 (Mouse)

Gene ID

6794 (STK11), 20869 (Stk11)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chimp (Chimpanzee), Chk (Chicken), Can (Canine), Ze (Zebrafish), African clawed frog, Mky (Monkey), Xen (Xenopus)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Flow Cytometry (F)

Background of STK11 antibody

Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Isoform 2: Has a role in spermiogenesis.

General readings

Xie,Z., (2006) J. Biol. Chem. 281 (10), 6366-6375

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

STK11 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-STK11 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802554) Mouse IgG1 OTI0A3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

STK11 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue (breast carcinoma) reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

STK11 antibody

Western blot analysis of LKB1 in PC-3 cell lysate with LKB1 antibody at 1 µg/ml in the (A) absence or (B) presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

STK11 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using LKB1 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

STK11 antibody

Western blot analysis of extracts from HeLa cells, using OR2B8 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

STK11 (N-term) antibody

Anti-STK11 / LKB1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. Rabbit Aff - Purified Hu, Ms P, WB
50 µg / €345.00
  OriGene Technologies, Inc.

STK11 antibody

Western blot analysis of LKB1 expression in Serum treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

STK11 antibody

Western blot analysis of extracts of variouscell lines , using STK11 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

STK11 antibody

STK11 Rabbit IgG Purified Hu, Ms P
0.1 ml / €325.00
  OriGene Technologies, Inc.

STK11 antibody

Western Blot: LKB1 Antibody [TA336904] - LKB1 antibody was tested in human fetal liver lysate. Rabbit Purified Hu, Ms C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

STK11 antibody

Western Blot: LKB1 Antibody [TA336905] - LKB1 antibody was tested in human testes lysate. Rabbit Purified Hu, Ms C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

STK11 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY STK11 (RC202885, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-STK11. Mouse IgG1 OTI1F10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

STK11 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY STK11 (RC202885, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-STK11. Mouse IgG1 OTI4B2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

STK11 antibody

Western blot analysis using STK11 antibody Cat.-No AM06552SU-N against NIH/3T3 (1),Raw246.7 (2), COS7 (3), Jurkat (4), HEK293 (5) and A431 (6) cell lysate. Mouse IgG1 4H12 Ascites Hu, Mky, Ms E, F, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

STK11 antibody

STK11 Rabbit IgG Purified Hu E, WB
0.1 mg / €480.00
  Acris Antibodies GmbH

STK11 (N-term) antibody

Western blot analysis of STK11 Antibody (N-term) (AP13928PU-N) in Ramos cell line lysates. STK11 was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

STK11 antibody

Western blot (WB) analysis of LKB1 antibody (Cat.-No.: AP20255PU-N) in extracts from raw264.7 cells. Rabbit Aff - Purified Hu, Ms WB
0.1 mg / €350.00
  Acris Antibodies GmbH

STK11 pSer334 antibody

Immunohistochemistry (IHC) analyzes of p-LKB1 antibody (Cat.-No.: AP20912PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms P
0.1 mg / €350.00
  Acris Antibodies GmbH

STK11 pSer428 antibody

Immunohistochemistry analysis of p-LKB1 Antibody (Cat.-No AP20913PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

STK11 antibody

Immunohistochemistry (IHC) analyzes of LKB1 antibody (Cat.-No.: AP21003PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

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