STRA6 antibody

Principal name

STRA6 antibody

Alternative names for STRA6 antibody

FLJ12541, PP14296, Stimulated by retinoic acid gene 6 protein homolog

SwissProt ID

O70491 (Mouse), Q0V8E7 (Bovin), Q4QR83 (Rat), Q9BX79 (Human), Q9H9U8 (Human)

Gene ID

363071 (Stra6), 64220 (STRA6), 20897

Available reactivities

Rt (Rat), Hu (Human), Ms (Mouse)

Available hosts

Goat, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F)

Background of STRA6 antibody

Stra6 gene encodes a membrane bound retinoic acid sensitive protein that facilitates the transport of vitamin A thru its soluble retinol binding protein complex. The transcription of Stra6 is directly regulated by the cellular levels of retinoic acid, which is a strong teratogen when exposed at elevated concentrations during early embryogenesis. The Stra 6 gene was studies in two human fetuses from consanguineous families with Matthew-Wood syndrome. These subjects exhibited severe microphthalmia, pulmonary agenesis, bilateral diaphragmatic eventration, duodenal stenosis, pancreatic malformations, and intrauterine growth retardation (1). In view of the increasing evidence that retinoic acid (RA) is a crucial signaling molecule during vertebrate development, several studies were initiated to systematically isolate the genes whose expression is induced by retinoic acid treatment at various exposure times. Several genes are induced in Pluripotent mouse P19 embryonal carcinoma cells (P19EC) RA treatment. At least 50 different cDNA fragments corresponding to RA-induced genes were isolated, 6 of them are known proteins, 4 of which are described as RA inducible, while the remaining 40 are unknown and novel genes. Two of these unknown novel genes are Stra1 and Stra6. Stra1 corresponds to the mouse ligand for Cek5 receptor protein tyrosine kinase and Stra6 is a vitamin A transporter (1). Stra6 is a membrane bound protein containing 10 TMD characteristic of solute carrier proteins. Stra6 protein is expressed in various tissues including fibroblasts and eye, a detailed analysis of distinct parts of an adult eye revealed expression in sclera, retina, retinal pigment epithelium and trabecular mashwork but not in choroid and iris (2).
A number of mutations in the Stra6 (chromosome 15) gene have been studied. A homozygous deletion generating a premature stop codon that led to absence of the immunoreactive protein in patient fibroblasts culture and three miss-sense mutations (P90L, P293L and T321P) caused significant alteration in the geometry of the loops connecting the transmembrane helices of Stra6. Two other mutations in the C-terminal region caused aberration in the SH2 binding motifs and in the phosphorylation of the Stra67 protein (2). Patients with these mutations show anophthalmia and distinct eyebrows as common signs along with alveolar dysplasia or a common congenital heart defect and diaphragmatic hernia.
Stra6 is a 99 kDa membrane bound protein with 10 TMD as commonly seen in all membrane transporter proteins.

General readings

Isken,A., (2008) Cell Metab. 7 (3), 258-268

17 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

STRA6 antibody

TA311392 (1.7ug/ml) staining of 3T3-L1 lysates (35ug protein in RIPA buffer). Primary incubation was 3 hour. Detected by chemiluminescence. Goat Aff - Purified Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

STRA6 antibody

WB Suggested Anti-STRA6 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

STRA6 antibody

ELISA: STRA6 Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

STRA6 Control Peptide

STRA6
0.1 mg / €250.00
  Acris Antibodies GmbH

STRA6 (255-275) antibody

STRA6 Rabbit IgG Aff - Purified Ms, Rt WB
0.1 mg / €420.00
  Acris Antibodies GmbH

STRA6 Control Peptide

STRA6
0.25 mg / €250.00
  Acris Antibodies GmbH

STRA6 (565-575) antibody

Western Blot of STRA6 using STRA6 Antibody Cat.-No AP10331PU-N. Molecular Weight Markers are labeled on the left. Rabbit IgG Aff - Purified Hu WB
0.1 mg / €420.00
  Acris Antibodies GmbH

STRA6 antibody

Western Blot analysis of STRA6 expression in transfected 293T cell line (H00064220-T01) by STRA6 MaxPab polyclonal antibody.

Lane 1: STRA6 transfected lysate(73.37 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

STRA6 antibody

STRA6 MaxPab rabbit polyclonal antibody. Western Blot analysis of STRA6 expression in mouse kidney. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

STRA6 antibody

The STRA6 polyclonal antibody ( Cat # PAB7606 ) ( 0.3 µg/ml ) staining of rat brain lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Rt E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

STRA6 antibody

Human HepG2; WB Suggested Anti-STRA6 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: HepG2 cell lysate; STRA6 antibody - N-terminal region (ARP49713_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

STRA6 antibody

ELISA: STRA6 Antibody [43200002] Rabbit Hu E, WB
50 µg / €640.00
  Novus Biologicals Inc.

STRA6 antibody

Western Blot: STRA6 Antibody [NBP1-59711] - This Anti-STRA6 antibody was used in Western Blot of HepG2     tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

STRA6 antibody

Immunohistochemistry-Paraffin: STRA6 Antibody [NBP1-83719] Immunohistochemical staining of human smooth muscle shows strong cytoplasmic positivity in smooth muscle cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

STRA6

STRA6 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

STRA6

STRA6 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

STRA6 293T Cell Transient Overexpression Lysate(Denatured)

STRA6 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

17 Item(s)

per page
  • LinkedIn