STRAP antibody

Principal name

STRAP antibody

Alternative names for STRAP antibody

MAWD, UNRIP, Serine-threonine kinase receptor-associated protein, MAP activator with WD repeats, UNR-interacting protein, WD-40 repeat protein PT-WD

SwissProt ID

Q5E959 (Bovin), Q5XIG8 (Rat), Q5ZL33 (Chick), Q9Y3F4 (Human), Q9Z1Z2 (Mouse)

Gene ID

11171 (STRAP), 20901 (Strap), 297699

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Chk (Chicken), Eq (Equine), Mky (Monkey), Xen (Xenopus), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of STRAP antibody

Unrip is part of the SMN complex that plays a role in snRNP assembly in the cytoplasm and pre mRNA splicing in the nucleus. Unrip interacts directly with Gemin 6 and Gemin 7 in the SMN complex. It is associated with the complex in the cytoplasm but not in the nucleus and thus is thought to play a role in it's subcellular localisation.
It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.

General readings

Seong,H.A., (2005) J. Biol. Chem. 280 (52), 42897-42908

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

STRAP antibody

  Rabbit Polyclonal Anti-STRAP Antibody  
WB Suggested Anti-STRAP Antibody Titration: 0.5 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

STRAP (230-280) antibody

Spleen: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Purified Bov, Can, Chk, Eq, Hu, Mky, Ms, Xen, Ze P, WB
50 µg / €470.00
  Acris Antibodies GmbH

STRAP (C-term) antibody

Western blot analysis of STRAP Antibody (C-term) (AP17770PU-N) in Hela cell line lysates (35ug/lane). STRAP (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

STRAP antibody

Human HepG2; WB Suggested Anti-STRAP Antibody Titration: 0.5ug/ml. Positive Control: HepG2 cell lysate; STRAP antibody - N-terminal region (ARP48038_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

STRAP antibody

Human HepG2; HepG2; STRAP antibody - C-terminal region (ARP48039_T100) in Human HepG2 cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

STRAP - human gene knockout kit via CRISPR

STRAP - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

STRAP - human gene knockout kit via CRISPR

STRAP - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

STRAP - human gene knockout kit via CRISPR

STRAP - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

STRAP - human gene knockout kit via CRISPR

STRAP - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Strap - mouse gene knockout kit via CRISPR

Strap - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Strap - mouse gene knockout kit via CRISPR

Strap - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Strap - mouse gene knockout kit via CRISPR

Strap - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Strap - mouse gene knockout kit via CRISPR

Strap - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

STRAP

  Recombinant protein of human serine/threonine kinase receptor associated protein (STRAP)  
STRAP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

STRAP

STRAP Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

STRAP

STRAP Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, STRAP (mGFP-tagged) - Human serine/threonine kinase receptor associated protein (STRAP), 200 uL, >10^7 TU/mL

Lenti ORF particles, STRAP (mGFP-tagged) - Human serine/threonine kinase receptor associated protein (STRAP), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, STRAP (Myc-DDK tagged) - Human serine/threonine kinase receptor associated protein (STRAP) , 200 uL, >10^7 TU/mL

Lenti ORF particles, STRAP (Myc-DDK tagged) - Human serine/threonine kinase receptor associated protein (STRAP) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Strap (GFP-tagged) - Mouse serine/threonine kinase receptor associated protein (Strap), 200 uL, >10^7 TU/mL

Lenti ORF particles, Strap (GFP-tagged) - Mouse serine/threonine kinase receptor associated protein (Strap), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Strap (Myc-DDK-tagged) - Mouse serine/threonine kinase receptor associated protein (Strap), 200 uL, >10^7 TU/mL

Lenti ORF particles, Strap (Myc-DDK-tagged) - Mouse serine/threonine kinase receptor associated protein (Strap), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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