STRAP antibody

Principal name

STRAP antibody

Alternative names for STRAP antibody

MAWD, UNRIP, Serine-threonine kinase receptor-associated protein, MAP activator with WD repeats, UNR-interacting protein, WD-40 repeat protein PT-WD

SwissProt ID

Q5E959 (Bovin), Q5XIG8 (Rat), Q5ZL33 (Chick), Q9Y3F4 (Human), Q9Z1Z2 (Mouse)

Gene ID

11171 (STRAP)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Chimp (Chimpanzee), Chk (Chicken), Eq (Equine), Mky (Monkey), Xen (Xenopus)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of STRAP antibody

Unrip is part of the SMN complex that plays a role in snRNP assembly in the cytoplasm and pre mRNA splicing in the nucleus. Unrip interacts directly with Gemin 6 and Gemin 7 in the SMN complex. It is associated with the complex in the cytoplasm but not in the nucleus and thus is thought to play a role in it's subcellular localisation.
It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.

General readings

Seong,H.A., (2005) J. Biol. Chem. 280 (52), 42897-42908

9 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

STRAP (230-280) antibody

Spleen: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Purified Bov, Can, Chk, Eq, Hu, Mky, Ms, Xen, Ze P, WB
50 µg / €470.00
  Acris Antibodies GmbH

STRAP (C-term) antibody

Western blot analysis of STRAP Antibody (C-term) (AP17770PU-N) in Hela cell line lysates (35ug/lane). STRAP (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

STRAP antibody

Human HepG2; WB Suggested Anti-STRAP Antibody Titration: 0.5ug/ml. Positive Control: HepG2 cell lysate; STRAP antibody - N-terminal region (ARP48038_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

STRAP antibody

Human HepG2; HepG2; STRAP antibody - C-terminal region (ARP48039_T100) in Human HepG2 cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

STRAP antibody

Western Blot: STRAP Antibody [NBP1-52949] - This Anti-STRAP antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 0.5ug/ml. Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt, Xen, Ze P, WB
50 µg / €440.00
  Novus Biologicals Inc.

STRAP antibody

Immunohistochemistry-Paraffin: STRAP Antibody [NBP1-82796] - Immunohistochemical staining of human kidney shows strong nuclear, cytoplasmic and membranous positivity in cells in tubules. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

STRAP

STRAP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

STRAP

STRAP Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

STRAP

STRAP Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

9 Item(s)

per page
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