stxA2 / Shiga-like toxin 2 subunit A antibody

Principal name

stxA2 / Shiga-like toxin 2 subunit A antibody

Alternative names for stxA2 / Shiga-like toxin 2 subunit A antibody

stx2A, Verocytotoxin 2 subunit A, Verotoxin 2 subunit A, rRNA N-glycosidase 2

SwissProt ID

P09385

Gene ID

1261950 (stxA2)

Ncbi ID

10730

Available reactivities

Bac (Bacteria)

Available hosts

Mouse

Available applications

Enzyme Immunoassay (E), Neutralisation (NEUT), Functional assay (FN), Western blot / Immunoblot (WB)

Background of stxA2 / Shiga-like toxin 2 subunit A antibody

Shiga-like toxins (SLTs), are also called Verotoxins. Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11, and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC.
SLT-I and Shiga toxin share >99% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct. Antibodies to SLT-II can also neutralize a variant of SLT-II (designated SLT-Iiv) produced by strains of E.coli that cause edema. SLT-IIv is cytotoxic for Vero but not HeLa cells, distinguishing it from SLT-II.
The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3) leading to receptor-mediated endocytosis.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Shiga-like toxin 2 subunit A antibody

Shiga-like toxin 2 subunit A Mouse IgG1 11E10 Purified E, FN, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Shiga-like toxin 2 subunit A antibody

Shiga-like toxin 2 subunit A Mouse IgG2 557 Purified E, NEUT
1 mg / €810.00
  Acris Antibodies GmbH

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