SUFU / SUFUH antibody

Principal name

SUFU / SUFUH antibody

Alternative names for SUFU / SUFUH antibody

Suppressor of fused homolog

SwissProt ID

Q9UMX1 (Human), Q9Z0P7 (Mouse)

Gene ID

51684 (SUFU)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Ze (Zebrafish), African clawed frog, Dros (Drosophila), Eq (Equine), Por (Porcine), Rb (Rabbit), GP (Guinea Pig)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunoprecipitation (IP)

Background of SUFU / SUFUH antibody

The Hedgehog (Hh) signaling pathway has conserved roles in development of species ranging from Drosophila to humans. Human supressor of fused HSu(Fu) acts as a negative regulator in the hedgehog signaling (SHH) pathway by down-regulating GLI1-mediated transactivation of target genes (1). HSu(fu) was found to repress activity of the zinc-finger transcription factor Gli, which mediates Hedgehog signaling in vertebrates, and to physically interact with Gli, Gli2 and Gli3 (2). The sonic hedgehog signaling pathway directs the embryonic development of diverse organisms and is disrupted in a variety of malignancies. Several of mutations encode truncated proteins that are unable to export the GLI transcription factor from nucleus to cytoplasm, resulting in the activation of SHH signaling. SUFU is a newly identified tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway through a newly identified mechanism (3).

General readings

Dunaeva M, et al. (2003) J. Biol. Chem. 278 (7): 5116-22.Murone M., et al. (2000) Nat. Cell Biol. 2:310-312

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SUFU / SUFUH antibody

Predicted band size: 54 kDa . Positive control: Jurkat cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 50 ug per lane Primary antibody: 1/100 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SUFU / SUFUH antibody

WB Suggested Anti-SUFU Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: PANC1 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SUFU / SUFUH antibody

WB Suggested Anti-SUFU Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

SUFU / SUFUH antibody

WB Suggested Anti-SUFU Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

SUFU / SUFUH (2-13) antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Bov, Can, Elephant, Eq, Hu, Mky, Ms, Por, Prim, Rt P
50 µg / €470.00
  Acris Antibodies GmbH

SUFU / SUFUH pSer342 antibody

SUFU / SUFUH Rabbit Aff - Purified Hu WB
0.1 ml / €320.00
  Acris Antibodies GmbH

SUFU / SUFUH pSer342 antibody

SUFU / SUFUH Rabbit Aff - Purified Hu WB
50 µl / €240.00
  Acris Antibodies GmbH

SUFU / SUFUH antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between SUFU and GLI1 HeLa cells were stained with anti-SUFU rabbit purified polyclonal 1:1200 and anti-GLI1 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

SUFU / SUFUH antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between STK36 and SUFU HeLa cells were stained with anti-STK36 rabbit purified polyclonal 1:1200 and anti-SUFU mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse IgG2a 1B2 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

SUFU / SUFUH antibody

Human PANC1; WB Suggested Anti-SUFU Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: PANC1 cell lysate; SUFU antibody - middle region (ARP33018_P050) in Human PANC1 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

SUFU / SUFUH antibody

Human HepG2; WB Suggested Anti-SUFU Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: HepG2 cell lysate; SUFU antibody - N-terminal region (ARP33019_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Dros, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

SUFU / SUFUH antibody

Human Uterus; Immunohistochemistry with Uterus tissue at an antibody concentration of 5ug/ml using anti-SUFU antibody (ARP39233_P050); SUFU antibody - middle region (ARP39233_P050) in Human Uterus cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

SUFU / SUFUH antibody

Immunohistochemistry: Suppressor of Fused Antibody (EPR1206Y) [NBP1-40515] - Immunohistochemical analysis of paraffin-embedded human testis using anti-SuFu Rabbit IgG EPR1206Y Hu F, IP, P, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

SUFU / SUFUH antibody

Immunohistochemistry-Paraffin: Suppressor of Fused Antibody [NBP1-87384] - Immunohistochemical staining of human adrenal gland shows strong nuclear and cytoplasmic positivity in cortical cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SUFU / SUFUH

SUFU / SUFUH Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

SUFU / SUFUH (1-484, His-tag)

SUFU / SUFUH Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

SUFU / SUFUH (1-484, His-tag)

SUFU / SUFUH Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

SUFU / SUFUH

SUFU / SUFUH Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

SUFU / SUFUH

SUFU / SUFUH Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

SUFU / SUFUH

SUFU / SUFUH Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

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