Alternative names for Sulfiredoxin-1 antibody
Sulfiredoxin1, SRXN1, C20orf139, SRX, EC=126.96.36.199
Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P)
Background of Sulfiredoxin-1 antibody
Sulfiredoxin, also designated Sulfiredoxin-1 and chromosome 20 open reading frame 139 (C20orf139), is a cytoplasmic antioxidant protein involved in signaling through catalytic reduction of oxidative modifications. It regulates peroxiredoxins (PRXs), a family of proteins that reduce hydroperoxides, by reducing the conserved cysteine from sulfinic to sulfenic acid. This impacts the role of PRX in the reduction of other downstream transcription factors and kinase signaling pathways. The Sulfiredoxin protein specifically acts on the PRDX1, PRDX2, PRDX3 and PRDX4 peroxiredoxins, but not on PRDX5 or PRDX6. Sulfiredoxin acts as a phosphotransferase and an athioltransferase and is widely expressed, with highest levels detected in lung, spleen, kidney and thymus tissues.
Jönsson TJ, Johnson LC, Lowther WT.
Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace.
Nature. 2008 Jan 3;451(7174):98-101.