Superoxide Dismutase 1 / SOD1 antibody
Principal name
Superoxide Dismutase 1 / SOD1 antibody
Alternative names for Superoxide Dismutase 1 / SOD1 antibody
SOD-1, CuZn-SOD, CuZnSOD, IPOA, ALS1, Superoxide dismutase [Cu-Zn]
SwissProt ID
P00441 (Human), P00442 (Bovin), P07632 (Rat), P08228 (Mouse), P09212 (Rabit), P09670 (Sheep)
Ncbi ID
NP_000445.1, NP_000445, NP_777040, 9606, 10090, 9913, 10116, NP_035564.1, NM_011434, NM_017050
Available reactivities
Available hosts
Available applications
Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Dot blot (Dot), Immunodiffusion (ID), Radioimmunoassay (R), Flow Cytometry (F)
Background of Superoxide Dismutase 1 / SOD1 antibody
Cu/Zn-superoxide dismutases (Cu/ Zn-SOD, SOD1) are metalloen zymes involved in the mechanisms of cellular defense against oxidative damage. They have been found in the cytoplasm of all the eukaryotic cells and in the periplasm of several bacterial species. Human SOD1 (approx. MW=19 kDa) is homodimers that contain one atom of zinc and one atom of copper per subunit and catalyze the dismutation of the superoxide anion (O 2 - •) quite efficiently at a rate close to the diffusion limit, over the entire pH range from 5 to 10.:
2O 2 - •+2H + → O 2 +H 2 O 2
(SOD1)
SOD1 possess a very compact and stable structure that is highly resistant to urea, SDS and proteolytic enzymes. SOD1 homodimer consist of two pi eces of eight-stranded β -barrel structure monomer close pack aged on each hydrophobic interface stabilized by intras ubunit disulfid e bond. SOD1 catalyzes the disproportion of superoxide anions via the alternate reduction and reoxidation of the copper ion at the active site of the enzyme. Recent studies in yeast have identified a protein termed the copper chaperone for superoxide dismutase (CCS) as the factor responsible for copper incorporation into SOD1 through direct protein-protein interaction. SO D1's endogenous role remains poorly understood. Mice lacking this enzyme were apparently healthy and displayed no increased sensitivity to hyperoxia. However, they exhibited a pronounced susceptibility to paraquat which induce acute oxidative stress in mice. As a relation to diseas e, elevated level of SOD1 is reported in Down syndrome patients as a result of increase of genedosage (trisomy). Moreover, linkage studies have revealed that mutations in SOD1 are responsible for 10-15% of case of the fetal motor neuron disease familial amyotrophic lateral sclerosis (FALS). Evidence from transgenic mice expressing FALS associated SOD1 mutations, as well as mice homozygous for a deletion of the SOD1 gene, indicates that this neuronal degeneration arises from a gain-of-function associated with the SOD1 mutations rather than loss-of-function. In addition to the legitimate dismutation reaction, SOD1 is able to catalyze surrogate reactions such as the production of •OH using anionic scavengers and H 2 O 2 and nitration of the tyrosine residues of proteins by peroxynitrate. These reactions might be the causes of cytotoxicity.
General readings
Hays,A.P., J. Neurol. Sci. 242 (1-2), 67-69 (2006)





















Western blot analysis of SOD1 expression in Jurkat (1) Raji (2), HeLa (3), WR19L (4) and PC12 (5) using AM26611AF-N

















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Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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TA326595 | Superoxide Dismutase 1 / SOD1 antibody |
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Rabbit Polyclonal Anti-SOD (Cu/Zn) Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Bov, Hu, Ms, Rt | C, E, IP, WB |
0.1 mg /
€426.00
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OriGene Technologies, Inc. | |||||||
Published recently! |
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TA500495 | Superoxide Dismutase 1 / SOD1 antibody |
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SOD1 (Superoxide Dismutase 1) mouse monoclonal antibody, clone OTI8B10 (formerly 8B10) | |||||||
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Mouse | IgG2b | OTI8B10 | Purified | Hu | F, P, WB |
0.1 ml /
€379.00
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OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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TA302692 | Superoxide Dismutase 1 / SOD1 antibody |
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Goat Polyclonal Antibody against SOD1 | |||||||
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Goat | Aff - Purified | Can, Hu, Ms, Rt | E, WB |
0.1 mg /
€360.00
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OriGene Technologies, Inc. | |||||||
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TA321133 | Superoxide Dismutase 1 / SOD1 antibody |
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Anti-SOD1 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, WB |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
TA326384 | Superoxide Dismutase 1 / SOD1 antibody |
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Rabbit polyclonal SOD (Cu/Zn) Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Bov, Can, Coral, Hst, Hu, Mky, Ms, Por, Rb, Rt, Sh, Xen | C, E, ICC/IF, IP, WB |
0.1 mg /
€426.00
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OriGene Technologies, Inc. | |||||||
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TA326813 | Superoxide Dismutase 1 / SOD1 antibody |
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Rabbit anti-SOD1 Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt |
0.1 mg /
€335.00
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OriGene Technologies, Inc. | |||||||
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TA338376 | Superoxide Dismutase 1 / SOD1 antibody |
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Rabbit Polyclonal Anti-SOD1 Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ye | P, WB |
0.1 mg /
€360.00
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OriGene Technologies, Inc. | |||||||
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TA343111 | Superoxide Dismutase 1 / SOD1 antibody |
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Rabbit Polyclonal Anti-SOD1 Antibody | |||||||
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Rabbit | IgG | Purified | Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Sh, Ze | WB |
50 µg /
€360.00
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OriGene Technologies, Inc. | |||||||
TA347910 | Superoxide Dismutase 1 / SOD1 antibody |
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Rabbit Polyclonal Anti-SOD1 Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€335.00
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OriGene Technologies, Inc. | |||||||
AM01230PU-N | Superoxide Dismutase 1 / SOD1 antibody |
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Mouse | IgG1 | 2F5 | Purified | Bov, Hu, Ms | C, E, P |
0.1 mg /
€420.00
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Acris Antibodies GmbH | |||||||
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AM06340SU-N | Superoxide Dismutase 1 / SOD1 antibody |
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Mouse | IgG1 | 6F5 | Ascites | Hu, Ms | E, ICC/IF, WB |
0.1 ml /
€400.00
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Acris Antibodies GmbH | |||||||
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AM26611AF-N | Superoxide Dismutase 1 / SOD1 antibody |
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Mouse | IgG1 | 1G2 | Azide Free | Hu | WB |
0.1 mg /
€390.00
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Acris Antibodies GmbH | |||||||
AP00192PU-N | Superoxide Dismutase 1 / SOD1 antibody |
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Rabbit | Aff - Purified | Eq, GP, Hu, Ms, Rt | C, IP, P, WB |
0.1 mg /
€340.00
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Acris Antibodies GmbH | |||||||
AP18205PU-N | Superoxide Dismutase 1 / SOD1 (Center) antibody |
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Rabbit | Hu | WB |
0.4 ml /
€370.00
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Acris Antibodies GmbH | |||||||
AP22845PU-N | Superoxide Dismutase 1 / SOD1 antibody |
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Rabbit | Purified | Eq, GP, Hu, Ms, Rt | C, IP, P, WB |
50 µg /
€380.00
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Acris Antibodies GmbH | |||||||
BP825 | Superoxide Dismutase 1 / SOD1 antibody |
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Sheep | IgG | Purified | Bov, Hu | C, E |
1 ml /
€400.00
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Acris Antibodies GmbH | |||||||
R1111 | Superoxide Dismutase 1 / SOD1 antibody |
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Rabbit | IgG | Serum | Bov | E, WB |
2 ml /
€1,180.00
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Acris Antibodies GmbH | |||||||
R1111A | Superoxide Dismutase 1 / SOD1 antibody |
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Rabbit | IgG | Azide Free | Bov | Dot, E, ICC/IF, ID, IP, R, WB |
10 mg /
€240.00
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Acris Antibodies GmbH | |||||||
R1111B | Superoxide Dismutase 1 / SOD1 antibody |
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Rabbit | IgG | Biotin | Bov | Dot, E, ICC/IF, ID, IP, R, WB |
1 ml /
€360.00
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Acris Antibodies GmbH | |||||||
R1111HRPS | Superoxide Dismutase 1 / SOD1 antibody |
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Rabbit | IgG | HRP | Bov | E, WB |
0.1 ml /
€460.00
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Acris Antibodies GmbH |