Superoxide dismutase 2 / SOD2 antibody

Principal name

Superoxide dismutase 2 / SOD2 antibody

Alternative names for Superoxide dismutase 2 / SOD2 antibody

Superoxide dismutase Mn

SwissProt ID

P00447 (Yeast), P04179 (Human), P07895 (Rat), P09671 (Mouse), P28768 (Pig), P41976 (Bovin), Q6P980, Q9XS41 (Horse)

Gene ID

6648 (SOD2), 24787 (Sod2), 20656

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Dros (Drosophila), GP (Guinea Pig), Hst (Hamster), Mky (Monkey), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Sh (Sheep), Xen (Xenopus), Ge (Gerbil), Av (Birds), Ze (Zebrafish)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP)

Background of Superoxide dismutase 2 / SOD2 antibody

Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2,5). In general, SODs play a major role in antioxidant defense mechanisms (4).
There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3).
The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa.
The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDa and it exists only in the extracellular space(7).
SOD3 can also be distinguished by its heparin-binding capacity (1).

General readings

1. Bastaki, M., Huen, K., Manzanillo, P., Chande, N., Chen, C., Balmes, J. R., Tager, I. B., Holland,
N. Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and
catalase in humans. Pharmacogenet. Genomics 16: 279-286, 2006.
2. Creagan, R., Tischfield, J., Ricciuti, F., Ruddle, F. H. Chromosome assignments of genes in man
using mouse-human somatic cell hybrids: mitochondrial superoxide dismutase (indophenol
oxidase-B, tetrameric) to chromosome 6. Humangenetik 20: 203-209, 1973.
3. Hiroi, S., Harada, H., Nishi, H., Satoh, M., Nagai, R., Kimura, A. Polymorphisms in the SOD2 and
HLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in
Japanese. Biochem. Biophys. Res. Commun. 261: 332-339, 1999.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Superoxide dismutase 2 / SOD2 antibody

Figure 2. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with SOD2 Monoclonal Antibody (Cat.#AM11059PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated. Mouse IgG1 37CT127.5.11.6 Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Superoxide dismutase 2 / SOD2 antibody

  Rabbit Polyclonal Anti-SOD2 Antibody - N-terminal region  
WB Suggested Anti-SOD2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human Placenta Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rt, Sh, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 antibody

  Anti-SOD2 Rabbit Polyclonal Antibody  
Predicted band size: 25 kDa . Positive control: Mouse liver tissue lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/950 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 30 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 antibody

  Anti-SOD2 Rabbit Polyclonal Antibody  
Predicted band size: 25 kDa . Positive control: Mouse liver tissue lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/650 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 30 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 antibody

  Rabbit polyclonal SOD (Mn) Antibody  
IHC localization of Mn SOD within the muscle fibres of LPS-injected rats (Left: Untreated, Right: treated with 3mmol*kg-1 NAC). Courtesy of E. Barreiro, IMIM, Spain. Rabbit IgG Aff - Purified Bov, Can, Chk, Ge, GP, Hst, Hu, Mky, Ms, Por, Rb, Rt, Sh, Xen C, E, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 antibody

  Rabbit Polyclonal Anti-SOD (Mn) Antibody  
Western blot analysis of Mn SOD in rat tissue lysates, using a 1:1000 dilution of the antibody Rabbit IgG Aff - Purified Bov, Can, Chk, Dros, GP, Hst, Hu, Mky, Ms, Por, Rb, Rt, Sh, Xen C, E, ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 antibody

  Rabbit anti-SOD2 Polyclonal Antibody  
Western blot analysis of extracts of K562 cell lines, using SOD2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 antibody

  Rabbit Polyclonal Anti-sod2 Antibody  
Western blot analysis of sod2 expression in Mouse Spinal Cord lysate Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 (119-130) antibody

  Goat Polyclonal Anti-MNSOD (aa119-130) Antibody  
TA348970 (0.1 ug/ml) staining of Mouse Spinal Cord lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Por, Rt, Ze E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 antibody

  SOD2 (Superoxide Dismutase 2) mouse monoclonal antibody, clone OTI1H6 (formerly 1H6)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOD2 (RC202330, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOD2. Mouse IgG1 OTI1H6 Purified Can, Hu WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Superoxide dismutase 2 / SOD2 antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt IP, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Superoxide dismutase 2 / SOD2 antibody

Superoxide dismutase 2 / SOD2 Mouse IgM SOD2 Purified Hu E, WB
1 mg / €390.00
  HyTest Ltd.

Superoxide dismutase 2 / SOD2 antibody

Western blot detection of SOD2. Recombinant human SOD1, SOD2, and SOD3 (1 ng) and lysates from human MCF-7, mouse NIH-3T3 and rat L6 cells were resolved by SDS-PAGE, transferred to Immobilon-P membrane and immunoblotted with 0.5 μg/mL mouse anti-SOD2 as described in Protocol on Datasheet. A 10 second exposure to film is shown. Mouse IgG2 349810 Purified Hu, Ms, Rt C, WB
0.1 mg / €340.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

Sod2 - mouse gene knockout kit via CRISPR

Sod2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Sod2 - mouse gene knockout kit via CRISPR

Sod2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sod2 - mouse gene knockout kit via CRISPR

Sod2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sod2 - mouse gene knockout kit via CRISPR

Sod2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Superoxide dismutase 2 / SOD2 (transcript variant 1)

  Recombinant protein of human superoxide dismutase 2, mitochondrial (SOD2), nuclear gene encoding mitochondrial protein, transcript variant 1  
Superoxide dismutase 2 / SOD2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 (transcript variant 2)

  Recombinant protein of human superoxide dismutase 2, mitochondrial (SOD2), nuclear gene encoding mitochondrial protein, transcript variant 2  
Superoxide dismutase 2 / SOD2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 (25-222, His-tag)

Superoxide dismutase 2 / SOD2 Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €670.00
  Acris Antibodies GmbH

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