Superoxide dismutase 2 / SOD2 antibody

Principal name

Superoxide dismutase 2 / SOD2 antibody

Alternative names for Superoxide dismutase 2 / SOD2 antibody

Superoxide dismutase Mn

SwissProt ID

P00447 (Yeast), P04179 (Human), P07895 (Rat), P09671 (Mouse), P28768 (Pig), P41976 (Bovin), Q6P980, Q9XS41 (Horse)

Gene ID

6648 (SOD2), 24787 (Sod2), 335799 (sod2), 20656

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), GP (Guinea Pig), Ge (Gerbil), Hst (Hamster), Mky (Monkey), Por (Porcine), Rb (Rabbit), Sh (Sheep), Xen (Xenopus), Dros (Drosophila), Av (Birds), Bab (Baboon), Ze (Zebrafish)

Available hosts

Goat, Mouse, Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Superoxide dismutase 2 / SOD2 antibody

Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2,5). In general, SODs play a major role in antioxidant defense mechanisms (4).
There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3).
The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa.
The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDa and it exists only in the extracellular space(7).
SOD3 can also be distinguished by its heparin-binding capacity (1).

General readings

Guégan C & Sola B Early and sequential recruitment of apoptotic effectors after focal permanent ischemia in mice. Brain Res 856:93-100 (2000). PubMed PMID: 10677615
Zhang HJ et al. Comparison of effects of two polymorphic variants of manganese superoxide dismutase on human breast MCF-7 cancer cell phenotype. Cancer Res 59:6276-83 (1999). PubMed PMID: 10626823
Manna SK et al. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1. J Biol Chem 273:13245-54 (1998). PubMed PMID: 9582369
Kurobe N et al. Sensitive enzyme immunoassay for human Cu/Zn superoxide dismutase. Clin Chim Acta 187:11-20 (1990). PubMed PMID: 2138526
Kurobe N et al. Sensitive enzyme immunoassay for human Mn superoxide dismutase. Clin Chim Acta 192:171-9 (1990). PubMed PMID: 2286014
Wong GH et al. Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor. Cell 58:923-31 (1989). PubMed PMID: 2476237

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Superoxide dismutase 2 / SOD2 antibody

Figure 2. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with SOD2 Monoclonal Antibody (Cat.#AM11059PU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated. Mouse IgG1 37CT127.5.11.6 Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Superoxide dismutase 2 / SOD2 antibody

WB Suggested Anti-SOD2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human Placenta Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rt, Sh, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 antibody

Human HK2; . Lanes: 1. 40 ug HK2 cell (kidney proximal tubular cell line) 2. 40 ug H2O2 treated human HK2 Cell lysate. 3. 40 ug H2O2 treated human HK2 Cell lysate. 4. 40 ug H2O2 treated human HK2 Cell lysate. 5. 40 ug H2O2 treated human HK2 Cell lysate. 6. 40 ug H2O2 treated human HK2 Cell lysate. Primary Antibody Dilution: 1:1000. Secondary Antibody: Goat anti-Rabbit HRP. Secondary Antibody Dilution: 1:2000. Gene Name: SOD2. Submitted by: The University of Queensland, School of Medicine, Centre for Kidney Disease Research.; SOD2 antibody - N-terminal region (ARP58529_P050) in Human HK2 cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Superoxide dismutase 2 / SOD2 antibody

Predicted band size: 25 kDa . Positive control: Mouse liver tissue lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/950 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 30 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 antibody

Predicted band size: 25 kDa . Positive control: Mouse liver tissue lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/650 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 30 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 antibody

IHC localization of Mn SOD within the muscle fibres of LPS-injected rats (Left: Untreated, Right: treated with 3mmol*kg-1 NAC). Courtesy of E. Barreiro, IMIM, Spain. Rabbit IgG Aff - Purified Bov, Can, Chk, Ge, GP, Hst, Hu, Mky, Ms, Por, Rb, Rt, Sh, Xen C, E, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 antibody

Western blot analysis of Mn SOD in rat tissue lysates, using a 1:1000 dilution of the antibody Rabbit IgG Aff - Purified Bov, Can, Chk, Dros, GP, Hst, Hu, Mky, Ms, Por, Rb, Rt, Sh, Xen C, E, ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 antibody

Western blot analysis of extracts of K562 cell lines, using SOD2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 antibody

Western blot analysis of sod2 expression in Mouse Spinal Cord lysate Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 (119-130) antibody

TA348970 (0.1 ug/ml) staining of Mouse Spinal Cord lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Por, Rt, Ze E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Superoxide dismutase 2 / SOD2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOD2 (RC202330, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOD2. Mouse IgG1 OTI1H6 Purified Can, Hu WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Superoxide dismutase 2 / SOD2 antibody

Western blot analysis of Mn SOD in rat tissue lysates, using a 1:1000 dilution of the antibody Rabbit IgG Aff - Purified Bov, Can, Chk, Dros, GP, Hst, Hu, Mky, Ms, Por, Rb, Rt, Sh, Xen C, E, ICC/IF, IP, P, WB
25 µg / €240.00
  Acris Antibodies GmbH

Superoxide dismutase 2 / SOD2 antibody

IHC localization of Mn SOD within the muscle fibres of LPS-injected rats (Left: Untreated, Right: treated with 3mmol*kg-1 NAC). Courtesy of E. Barreiro, IMIM, Spain. Rabbit IgG Aff - Purified Bov, Can, Chk, Ge, GP, Hst, Hu, Mky, Ms, Por, Rb, Rt, Sh, Xen C, E, ICC/IF, IP, WB
25 µg / €240.00
  Acris Antibodies GmbH

Superoxide dismutase 2 / SOD2 antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt IP, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Superoxide dismutase 2 / SOD2 antibody

SOD2 MaxPab polyclonal antibody. Western Blot analysis of SOD2 expression in human spleen. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Superoxide dismutase 2 / SOD2 antibody

SOD2 MaxPab polyclonal antibody. Western Blot analysis of SOD2 expression in human spleen. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Superoxide dismutase 2 / SOD2 antibody

Superoxide dismutase 2 / SOD2 Mouse Hu WB
50 µl / €370.00
  Abnova Taiwan Corp.

Superoxide dismutase 2 / SOD2 antibody

Superoxide dismutase 2 / SOD2 Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

Superoxide dismutase 2 / SOD2 antibody

SOD2 MaxPab rabbit polyclonal antibody. Western Blot analysis of SOD2 expression in human liver. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Superoxide dismutase 2 / SOD2 antibody

Immunoblot analysis of cell lysates. Lane 1 : Hela cell lysate, lane 2 : mouse brain and lane 3 : rat brain. Mouse IgG1 2A1 Hu E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

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