Supervillin / SVIL antibody

Principal name

Supervillin / SVIL antibody

Alternative names for Supervillin / SVIL antibody

Archvillin

SwissProt ID

O95425 (Human), Q8K4L3 (Mouse)

Gene ID

6840 (SVIL)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Supervillin / SVIL antibody

Supervillin is an F-actin-binding protein originally with two reported isoforms of 205/250 kDa. The longer isoform, named archvillin, is muscle-specific. Supervillin is a tightly bound peripheral membrane protein that is concentrated at sites of epithelial cell-cell adhesion. It contributes to cell-cell adhesion, motility regulation, and information transfer between cell compartments. The COOH-terminus of supervillin is homologous to villin/gelsolin but is not responsible for the tight binding to the actin cytoskeleton in vivo. The NH2-terminus contains functional nuclear localization sequences and F-actin and myosin II binding domains. It has been suggested that supervillin may mediate actin and myosin II filament organization at cholesterol-rich membrane domains. Supervillin has been identified as a transcriptional activator of the androgen receptor. Supervillin is found in many cells of several species, but is most abundant in muscle, bone marrow, thyroid gland, and salivary gland.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Supervillin / SVIL antibody

Supervillin / SVIL Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Supervillin / SVIL antibody

Detection limit for recombinant GST tagged SVIL is approximately 3ng/ml as a capture antibody. Mouse IgG2a 6E10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Supervillin / SVIL antibody

Immunohistochemistry-Paraffin: Supervillin Antibody [NBP1-87559] Immunohistochemical staining of human skeletal muscle shows distinct cytoplasmic positivity. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Supervillin / SVIL antibody

Immunohistochemistry-Paraffin: Supervillin Antibody [NBP1-90363] - Immunohistochemical staining of human skeletal muscle shows moderate cytoplasmic positivity. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Supervillin / SVIL

Supervillin / SVIL Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Supervillin / SVIL

Supervillin / SVIL Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

6 Item(s)

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