SV40 Large T antigen antibody

Principal name

SV40 Large T antigen antibody

Alternative names for SV40 Large T antigen antibody

Simian virus 40, LT-AG

SwissProt ID

P03070 (Sv40)

Gene ID

1489531 (P03070)

Available reactivities

Hu (Human)

Available hosts

Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of SV40 Large T antigen antibody

SV40, Simian Virus 40 is a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors. SV40 is believed to suppress the transcriptional properties of tumor-suppressing p53 in humans through the SV40 large T-antigen and SV40 small T-antigen. It is generally assumed that large T-antigen is the major protein involved in neoplastic processes and the large T-antigen predominantly exerts its effect through deregulation of tumor suppressor p53, which is responsible for initiating regulated cell death (“apoptosis”), or cell cycle arrest when a cell is damaged. A mutated p53 gene may contribute to uncontrolled cellular proliferation, leading to a tumor. The hypothesis that SV40 might cause cancer in human has been a particularly controversial area of research. Some research has suggested that SV40 is associated with brain tumors, bone cancers, non-Hodgkin lymphoma and malignant mesothelioma. SV40 may act as a cocarcinogen with crocidolite to cause mesothelioma.

6 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SV40 Large T antigen antibody

SV40 Large T antigen Mouse IgG2a Pab101 Purified ICC/IF, IP, WB
0.1 mg / €480.00
  Acris Antibodies GmbH

SV40 Large T antigen (N-term) antibody

Methanol-fixed, SV40 transformed human cell line stained with SV40 Large T Antigen (AM00600PU-N) using peroxidase-conjugate and AEC chromogen. Note nuclear staining of cultured cells. Mouse IgG2a Pab108 Purified ICC/IF, IP, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

SV40 Large T antigen antibody

SV40 Large T antigen Mouse IgG2a MRQ-4 Supernatant Hu C, P
1 ml / €780.00
  Acris Antibodies GmbH

SV40 Large T antigen antibody

Western Blotting Analysis: Representative lot data. Cos-1 cell lysate was probed with Cat. No. AM50479PU-N, Anti-SV40 Large T Antigen, clone PAb416 (1 µg/mL). Proteins were visualized using a Goat Anti-Mouse IgG (H&L) secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates SV40 Large T Antigen (~82 kDa). Mouse IgG2a PAb416 Purified ICC/IF, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

SV40 Large T antigen antibody

SV40 Large T antigen Mouse IgG2a PAb419 Aff - Purified ICC/IF, IP

Regular Price: 0.5 ml / €350.00

Special Price: 0.5 ml / €297.50

  GeneTex Inc.

SV40 Large T antigen antibody

SV40 Large T antigen Mouse IgG2a PAb416 Aff - Purified ICC/IF, IP, WB

Regular Price: 0.5 ml / €350.00

Special Price: 0.5 ml / €297.50

  GeneTex Inc.

6 Item(s)

per page
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