SV40 Large T antigen antibody

Principal name

SV40 Large T antigen antibody

Alternative names for SV40 Large T antigen antibody

Simian virus 40, LT-AG

SwissProt ID

P03070 (Sv40)

Gene ID

1489531 (P03070)

Available reactivities

Hu (Human)

Available hosts


Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of SV40 Large T antigen antibody

SV40, Simian Virus 40 is a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors. SV40 is believed to suppress the transcriptional properties of tumor-suppressing p53 in humans through the SV40 large T-antigen and SV40 small T-antigen. It is generally assumed that large T-antigen is the major protein involved in neoplastic processes and the large T-antigen predominantly exerts its effect through deregulation of tumor suppressor p53, which is responsible for initiating regulated cell death (“apoptosis”), or cell cycle arrest when a cell is damaged. A mutated p53 gene may contribute to uncontrolled cellular proliferation, leading to a tumor. The hypothesis that SV40 might cause cancer in human has been a particularly controversial area of research. Some research has suggested that SV40 is associated with brain tumors, bone cancers, non-Hodgkin lymphoma and malignant mesothelioma. SV40 may act as a cocarcinogen with crocidolite to cause mesothelioma.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SV40 Large T antigen antibody

SV40 Large T antigen Mouse IgG2a MRQ-4 Supernatant Hu C, P
1 ml / €910.00
  Acris Antibodies GmbH

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