swi6 antibody

Principal name

swi6 antibody

Alternative names for swi6 antibody

Chromatin-associated protein swi6

SwissProt ID

P40381 (Schpo)

Gene ID

2541633 (swi6)

Available reactivities

Ye (Yeast), Hu (Human), Ms (Mouse)

Available hosts


Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP)

Background of swi6 antibody

The chromatin structure of Fission yeast centromeres is regulated epigenetically. In the central core domain, the histone H3 variant Cnp1(CENP-A) plays a key role. In the flanking heterochromatin domain, histones are kept underacetylated by the histone deacetylases (HDACs) Clr3, Clr6 and Sir2, and methylated by Clr4 methyltransferase (HMTase) to create a specific binding site for the Swi6 protein. Swi6 then directly mediates cohesin binding to the centromeric heterochromatin. Recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. Involved in the repression of the silent mating-type loci MAT2 and MAT3. May compact MAT2/3 into a heterochromatin-like conformation which represses the transcription of these silent cassettes. Swi6 interacts with histone H3 methylated at Lys-9 and with the cohesin subunit psc3. Swi6 associates with Swi4 to activate HO and many other late G1-specific transcripts in budding yeast. In contrast, histone H3 methylated at Lys9 and its interacting protein Swi6/HP1, which define heterochromatin, coated extended domains associated with a variety of repeat elements and small islands corresponding to meiotic genes. Contains two chromo domains.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

swi6 (314-328) antibody

swi6 Rabbit IgG Aff - Purified Ye E, WB
  Acris Antibodies GmbH

swi6 antibody

swi6 Rabbit Hu, Ms E, IP, WB
  Abnova Taiwan Corp.

swi6 antibody

swi6 Rabbit IgG Aff - Purified Ye E, WB
  Novus Biologicals Inc.

3 Item(s)

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