SYK antibody

Principal name

SYK antibody

Alternative names for SYK antibody

Tyrosine-protein kinase SYK, Spleen tyrosine kinase

SwissProt ID

P43405 (Human), P48025 (Mouse), Q00655 (Pig), Q64725 (Rat)

Gene ID

6850 (SYK), 20963 (Syk), 3735 (KARS)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Bov (Bovine), Por (Porcine), Chk (Chicken), Rb (Rabbit), Mky (Monkey)

Available hosts

Mouse, Rabbit, Goat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C), ELISA (detection) (E(detection))

Background of SYK antibody

Syk, a non-receptor tyrosine kinase, belongs to the Syk-Zap70 family of protein tyrosine kinase (PTK) and is involved in a wide variety of cellular functions including the pathogenesis of malignant cancer (1). Ubiquitously expressed in hematopoietic cells, Syk has been found to be an effector of B cell receptor (BCR) and functions in B & T cell lymphopoiesis. In the absence of Syk, B cell development is blocked (2). Upon binding to the BCR and to the cell surface receptor of hematopoietic cells (3), Syk is activated and phosphorylates Phospholipase C resulting in the downstream activation of ERK & JNK kinase. Syk also phosphorylates PI3-K activating the Akt pathway (4). Cross-linking of the T cell antigen receptor (TCR)-CD3 complex induces rapid tyrosine phosphorylation and then activation of Syk, which in turn phosphorylates a multitude of intracellular substrates such as Cbl (5). Substitution of Tyr-525 and Tyr-526 at the autophosphorylation site of Syk in mCD8-Syk substantially reduced the kinase activity and the binding to PLC-gamma1 SH2(C) in vitro (6).

General readings

Rogers NC, Slack EC, Edwards AD, Nolte MA, Schulz O, Schweighoffer E, Williams DL, Gordon S, Tybulewicz VL, Brown GD, Reis E Sousa C. Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity. 2005 Apr;22(4):507-17.

  1. Quick-Filters:
  2. Cited (1)
  3. Overnight Delivery (1)

Items 1 to 20 of 82 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SYK (5-360) antibody

Immunofluorescence staining of Syk in human HeLa cell line using anti-Syk (SYK-01; green). Actin cytoskeleton was decorated by phalloidin (red) and cell nuclei stained with DAPI (blue). Mouse IgG1 SYK-01 Purified Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 mg / €260.00
  Acris Antibodies GmbH

SYK antibody

AP15804PU Syk antibody staining of Human Bone  Marrow. Rabbit Purified Hu IP, P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

SYK antibody

AP15804PU Syk antibody staining of Human Bone  Marrow. Rabbit Purified Hu IP, P, WB
1 ml / €440.00
  Acris Antibodies GmbH

SYK antibody

AP15804PU Syk antibody staining of Human Bone  Marrow. Rabbit Purified Hu IP, P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

SYK antibody

TA302693 (1µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SYK antibody

Predicted band size: 72 kDa . Positive control: Raji cell lysate. Recommended dilution: 1/200-1000. (Gel: 8%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/200 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SYK antibody

Predicted cell location: Cytoplasm. Positive control: Human lymphoma tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded human lymphoma tissue using SYK antibody at dilution 1/15, on the right is treated with the fusion protein. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SYK antibody

Western blot analysis of SYK expression in UV treated K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SYK antibody

Western blot analysis of SYK expression in UV treated K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SYK antibody

Western blot analysis of extracts from Jurkat cells, using SYK  Antibody. The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SYK antibody

Western blot analysis of extracts from HepG2 cells, using Syk antibody (#TA326257).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SYK antibody

SYK Rabbit IgG Purified Hu, Ms, Rt P
0.1 ml / €325.00
  OriGene Technologies, Inc.

SYK antibody

Jurkat cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with monoclonal anti-Syk (clone 4D10.2) antibody.  Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection system. Mouse IgG2a 4D10.2 Purified Hu IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SYK antibody

Mouse spleen (1) and PBMC (2) cell lysates were resolved by electrophoresis, transferred to nitrocellulose and probed with clone 5F5 (mouse-specific). Proteins were visualized using an HRP goat anti-mouse secondary antibody conjugate and a chemiluminescent system. Mouse IgG1 5F5 Purified Ms IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SYK antibody

Figure 1. Immunohistochemical staining using Syk antibody (AM05319PU-N) on formalin fixed, paraffin embedded human lymphoma. Mouse IgG2a 4D10.1 Purified Hu C, E, IP, WB
0.1 mg / €570.00
  Acris Antibodies GmbH

SYK antibody

Mouse spleen (1) and PBMC (2) cell lysates were resolved by electrophoresis, transferred to nitrocellulose and probed with clone 5F5 (mouse-specific). Proteins were visualized using an HRP goat anti-mouse secondary antibody conjugate and a chemiluminescent system. Mouse IgG1 5F5 Purified Ms IP, WB
25 µg / €240.00
  Acris Antibodies GmbH

SYK antibody

Immunohistochemistry (IHC) analyzes of SYK antibody (Cat.-No.. AP06335PU-N) in paraffin-embedded human prostate carcinoma tissue. Rabbit Aff - Purified Hu E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

SYK antibody

Immunohistochemistry (IHC) analyzes of SYK antibody (Cat.-No.: AP06336PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

SYK antibody

Immunohistochemistry (IHC) analyzes of SYK antibody (Cat.-No.: AP06416PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

SYK pTyr323 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using syk (phospho-Tyr323) Antibody AP08041PU. Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Items 1 to 20 of 82 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  • LinkedIn