Synapsin-1 antibody

Principal name

Synapsin-1 antibody

Alternative names for Synapsin-1 antibody

Synapsin I, Brain protein 4.1, SYN1

SwissProt ID

O62732 (Canfa), O88935 (Mouse), P09951 (Rat), P17599 (Bovin), P17600 (Human)

Gene ID

6853 (SYN1), 20964 (Syn1), 24949, 281510

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Xen (Xenopus), Ze (Zebrafish), Can (Canine), Mky (Monkey), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Enzyme Immunoassay (E), Dot blot (Dot)

Background of Synapsin-1 antibody

Synapsin I (synapsin Ia and Ib, MW ~ 80,000 and 77,000 are collectively referred to as synapsin I) is a neuron specific protein that is localized to nerve terminals. The synapsin protein is an excellent marker for synaptic terminals and it can be used to estimate synaptic density and or synaptogenesis. It is thought that synapsin I cross-links synaptic vesicles to the cytoskeleton and thereby limits the ability of these synaptic vesicles to move to active zones and fuse with the plasma membrane during exocytosis. In addition to their role in neurotransmission, the synapsins are also thought to play a role in synapse formation. The appearance of synapsin I immunoreactivity correlates precisely with the development of synapses in the CNS. The synapsin protein is an excellent marker for synaptic terminals and it can be used to estimate synaptic density and or synaptogenesis. The appearance of synapsin I was a precise indicator of synapse formation and that synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. (2-4)

General readings

Jovanovic JN, Benfenati, F, Siow YL, Sihra TS, Sanghera JS, Pelech SL, Greengard P,Czernik AJ (1996) Neurotrophins stimulate phosphorylation of Synapsin I by MAP kinase and regulate SynapsinI-actin interactions. Neurobiology 93:3679-3683.Czernik AJ, Pang DT, Greengard P (1987) Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I. Proc Natl Acad Sci (USA) 84:7518-7522.Feng J, Chi P, Blanpied TA, Xu YM, Magarinos AM, Ferreira A, Takahashi RH, Kao HT, McEwen BS, Ryan TA, Augustine GJ, Greengard P (2002) Regulation of neurotransmitter release by synapsin III. J Neurosci 22:4372-4380. Jovanovic JN, Sihra TS, Nairn AC, Hemmings HC, Jr., Greengard P, Czernik AJ (2001) Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals. J Neurosci 21:7944-7953.Kao HT, Song HJ, Porton B, Ming GL, Hoh J, Abraham M, Czernik AJ, Pieribone VA, Poo MM, Greengard P (2002) A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth. Nature Neurosci 5:431-437.Nayak AS, Moore CI, Browning MD (1996) CAM kinase II phosphorylation of the presynaptic protein synapsin is persistently increased during expression of long-term potentiation. Proc Natl Acad Sci (USA) 93:15451-15456.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Synapsin-1 antibody

Western blot of 10 ug of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~78k synapsin I doublet protein. Rabbit IgG Aff - Purified Hu, Ms, Rt C, ICC/IF, IP, WB
10 µg / €325.00
  OriGene Technologies, Inc.

Synapsin-1 pSer9 antibody

Cultured mouse caudate neurons showing synapsin I when phosphorylated at Ser9 Rabbit IgG Aff - Purified Bov, Hu, Ms, Rt, Xen, Ze C, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Synapsin-1 pSer62/67 antibody

Western blot of Rat cortex lysate showing specific immunolabeling of the ~78k Synapsin I phosphorylated at Ser62/67 (Control). Immunolabeling is blocked by preadsorption with the phospho-peptide used as antigen (Peptide) but not by the corresponding dephospho-peptide (not shown). Rabbit IgG Aff - Purified Bov, Ms, Rt Dot, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Synapsin-1 pSer603 antibody

Figure 1. Western blot of rat cortex lysate showing specific immunolabeling of the ~78k Synapsin I phosphorylated at Ser603 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase). The blot is identical to the control except that it was incubated in lambda-Ptase (1200 units for 30 min) before being exposed to the phospho-Ser603 synapsin I antibody. The immunolabeling is completely eliminated by treatment with lambda-Ptase. Rabbit IgG Aff - Purified Bov, Hu, Ms, Rt, Xen, Ze WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Synapsin-1 antibody

Western blot of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~78k synapsin I doublet protein. Rabbit IgG Serum Hu, Ms, Rt WB
50 µl / €325.00
  OriGene Technologies, Inc.

Synapsin-1 antibody

Western blot analysis of Synapsin expression in PMA treated 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Synapsin-1 pSer9 antibody

Immunofluorescence staining of methanol-fixed HeLa cells using Synapsin pSer9 antibody Cat.-No AP02514PU (Red). Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Synapsin-1 pSer9 antibody

Immunofluorescence staining of methanol-fixed HeLa cells using Synapsin pSer9 antibody Cat.-No AP02514PU (Red). Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, WB
50 µl / €240.00
  Acris Antibodies GmbH

Synapsin-1 antibody

Western blot analysis of extract from C6 cells using Synapsin antibody Cat.-No AP02760PU Rabbit Aff - Purified Hu, Ms WB
0.1 ml / €270.00
  Acris Antibodies GmbH

Synapsin-1 antibody

Western blot analysis of extract from C6 cells using Synapsin antibody Cat.-No AP02760PU Rabbit Aff - Purified Hu, Ms WB
50 µl / €230.00
  Acris Antibodies GmbH

Synapsin-1 pSer549 antibody

Synapsin-1 Rabbit IgG Purified Bov, Can, Hu, Mky, Ms, Rt WB
0.1 ml / €510.00
  Acris Antibodies GmbH

Synapsin-1 antibody

Synapsin-1 Rabbit IgG Purified Bov, Hu, Ms, Rt C, ICC/IF, IP, WB
10 µg / €510.00
  Acris Antibodies GmbH

Synapsin-1 pSer603 antibody

Synapsin-1 Rabbit IgG Purified Bov, Hu, Ms, Rt, Xen, Ze WB
0.1 ml / €510.00
  Acris Antibodies GmbH

Synapsin-1 pSer9 antibody

Synapsin-1 Rabbit IgG Purified Bov, Hu, Ms, Rt, Xen, Ze WB
0.1 ml / €510.00
  Acris Antibodies GmbH

Synapsin-1 antibody

Immunohistochemistry (IHC) analyzes of SYN1 antibody (Cat.-No.: AP06585PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Synapsin-1 pSer549 antibody

Immunostaining of cultured mouse caudate neurons showing synapsin I when phosphorylated at Ser549. Cells and photo courtesy of QBMCellScience. Rabbit IgG Aff - Purified Bov, Can, Hu, Ms, non-Human Primates, Rt C, Dot, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Synapsin-1 antibody

Immunohistochemistry analysis of Synapsin-1 Antibody (Cat.-No AP20761PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Synapsin-1 pSer9 antibody

Immunohistochemistry analysis of Synapsin-1 Antibody (Cat.-No AP20870PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Synapsin-1 antibody

Immunostaining of cultured rat caudate neurons showing punctate distribution of synapsin in green and MAP in red. Rabbit Ig Aff - Purified Bov, Hu, Ms, Rt ICC/IF, IP, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Synapsin-1 antibody

Synapsin-1 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

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