Synaptophysin / SYP antibody

Principal name

Synaptophysin / SYP antibody

Alternative names for Synaptophysin / SYP antibody

Neuroendocrine Marker, Major synaptic vesicle protein p38

SwissProt ID

P07825 (Rat), P08247 (Human), P20488 (Bovin), Q62277 (Mouse)

Gene ID

6855 (SYP), 20977 (Syp), 24804, 280937

Available reactivities

Hu (Human), Rt (Rat), Mky (Monkey), Ms (Mouse), Bov (Bovine), Hst (Hamster), Por (Porcine), Chk (Chicken), Ze (Zebrafish), African clawed frog, Sh (Sheep), Can (Canine), Prim (Primate)

Available hosts

Mouse, Rabbit, Sheep

Available applications

Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E), Immunoprecipitation (IP)

Background of Synaptophysin / SYP antibody

Syptophysin is the major integral membrane protein of small syptic vesicles. It belongs to a family of proteins which includes syptogyrin and syptoporin. The protein contains 4 transmembrane domains and cytoplasmic N- and C-termini. There are two intravesicular loops that contain disulfide bonds. The protein is N-glycosylated on the first intravesicular loop, a modification important for the syptic vesicle targeting of syptophysin. Indeed, a mutant form of the protein, uble to undergo glycolysation, leads to the accumulation of the protein in the cell body of neurons indicating that N-glycosylation is required for the syptic localization of syptophysin. The C-termil tail is extensively phosphorylated on Tyr residues. However, the biological significance of the post-translatiol modification is not yet determined. Although exact and specific role of syptophysin remains a mystery, a study suggests that the protein is required for efficient endocytosis of syptic vesicles in cultured hippocampal neurons. Since syptophysin is exclusively detected in syptic vesicles, it is widely used as a marker for presyptic vesicles. Genetic screening in humans and behavioral studies in rodents show that loss of syptophysin expression or expression of a truncated form of the protein may be attributed to mental retardation and/or learning deficits. Interestingly though, syptic transmission in syptophysin knockout mice remains normal.

General readings

1 McMahon, H. T.; Bolshakov, V. Y.; Janz, R.; Hammer, R. E.; Siegelbaum, S. A.; Sudhof, T. C.: Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release. Proc. Nat. Acad. Sci. 93: 4760-4764, 1996.
2 Cremin, S. M.; Greer, W. L.; Bodok-Nutzati, R.; Schwartz, M.; Peacocke, M.; Siminovitch, K. A.: Linkage of Wiskott-Aldrich syndrome with three marker loci, DXS426, SYP and TFE3, which map to the Xp11.3-p11.22 region. Hum. Genet. 92: 250-253, 1993.
3 Ozcelik, T.; Lafreniere, R. G.; Archer, B. T., III; Johnston, P. A.; Willard, H. F.; Francke, U.; Sudhof, T. C. : Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse. Am. J. Hum. Genet. 47: 551-561, 1990.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Synaptophysin / SYP antibody

Synaptophysin / SYP Mouse IgG2b UMAB112 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Synaptophysin / SYP antibody

Synaptophysin / SYP Mouse IgG2b UMAB112 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Synaptophysin / SYP antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-SYP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506044) Mouse IgG1 OTI1B10 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Synaptophysin / SYP antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-SYP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506068) Mouse IgG1 OTI1G3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Synaptophysin / SYP antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-SYP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506497) Mouse IgG1 OTI1D4 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Synaptophysin / SYP antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-SYP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506520) Mouse IgG1 OTI2D8 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Synaptophysin / SYP antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-SYP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506521) Mouse IgG2a OTI1C9 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Synaptophysin / SYP antibody

Immunofluorescent staining of HeLa cells using anti-SYP mouse monoclonal antibody (TA506530). Mouse IgG1 OTI5H2 Purified Can, Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Synaptophysin / SYP (C-term) antibody

Cytoplasmic expression of synaptophysin in: neuroendocrine tumor of the pancreas (NET, grade 1) (A), normal pancreatic islets of Langerhans (B), typical carcinoid of the lung (C) and neuroendocrine tumor of the small intestine (NET, grade 1) (D). Kindly performed and provided by Marián Švajdler, MD and Dr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG Q21-Q Aff - Purified Hu C, P
0.1 ml / €280.00
  DB Biotech, spol. s r.o.

Sample sizes available

Synaptophysin / SYP (C-term) antibody

Cytoplasmic expression of synaptophysin in: neuroendocrine tumor of the pancreas (NET, grade 1) (A), normal pancreatic islets of Langerhans (B), typical carcinoid of the lung (C) and neuroendocrine tumor of the small intestine (NET, grade 1) (D). Kindly performed and provided by Marián Švajdler, MD and Dr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG Q21-Q Aff - Purified Hu C, P
0.2 ml / €370.00
  DB Biotech, spol. s r.o.

Sample sizes available

Synaptophysin / SYP (C-term) antibody

Cytoplasmic expression of synaptophysin in: neuroendocrine tumor of the pancreas (NET, grade 1) (A), normal pancreatic islets of Langerhans (B), typical carcinoid of the lung (C) and neuroendocrine tumor of the small intestine (NET, grade 1) (D). Kindly performed and provided by Marián Švajdler, MD and Dr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG Q21-Q Aff - Purified Hu C, P
0.5 ml / €460.00
  DB Biotech, spol. s r.o.

Sample sizes available

Synaptophysin / SYP (C-term) antibody

Cytoplasmic expression of synaptophysin in: neuroendocrine tumor of the pancreas (NET, grade 1) (A), normal pancreatic islets of Langerhans (B), typical carcinoid of the lung (C) and neuroendocrine tumor of the small intestine (NET, grade 1) (D). Kindly performed and provided by Marián Švajdler, MD and Dr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG Q21-Q Aff - Purified Hu C, P
1 ml / €720.00
  DB Biotech, spol. s r.o.

Sample sizes available

Synaptophysin / SYP (C-term) antibody

AM11195PU Synatophysin antibody staining of Human neuroendocrine tumor. Rabbit SP11 Supernatant Hu P, WB
0.5 ml / €330.00
  Acris Antibodies GmbH

Synaptophysin / SYP (C-term) antibody

AM11195PU Synatophysin antibody staining of Human neuroendocrine tumor. Rabbit SP11 Supernatant Hu P, WB
1 ml / €460.00
  Acris Antibodies GmbH

Synaptophysin / SYP (C-term) antibody

AM11195PU Synatophysin antibody staining of Human neuroendocrine tumor. Rabbit SP11 Supernatant Hu P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

Synaptophysin / SYP (C-term) antibody

Human pancreas stained with anti-Synaptophysin antibody Rabbit Purified Hu, Rt P
0.5 ml / €300.00
  Acris Antibodies GmbH

Synaptophysin / SYP (C-term) antibody

Human pancreas stained with anti-Synaptophysin antibody Rabbit Purified Hu, Rt P
1 ml / €330.00
  Acris Antibodies GmbH

Synaptophysin / SYP (C-term) antibody

Human pancreas stained with anti-Synaptophysin antibody Rabbit Purified Hu, Rt P
0.1 ml / €170.00
  Acris Antibodies GmbH

Synaptophysin / SYP antibody

Western blot analysis of extracts from LOVO cells, using Synaptophysin antibody (#TA312081).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Synaptophysin / SYP antibody

IHC analysis of Synaptophysin using the antibody Mouse IgG1 EP10 Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

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