Synaptotagmin-1 antibody

Principal name

Synaptotagmin-1 antibody

Alternative names for Synaptotagmin-1 antibody

SYT1, SVP65, SYT, Synaptotagmin1, Synaptotagmin I, SytI, p65

SwissProt ID

P21579 (Human), P21707 (Rat), P46096 (Mouse), P47191 (Chick), P48018 (Bovin)

Gene ID

20979 (Syt1), 25716, 6857 (SYT1), 3996857 (IPR003704)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Bov (Bovine), Mky (Monkey), Can (Canine), Ze (Zebrafish), Fi (Fish)

Available hosts

Chicken, Rabbit, Mouse, Goat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Dot blot (Dot)

Background of Synaptotagmin-1 antibody

Synaptotagmin I (Syt1), located on human chromosome 12, is a member of synaptotagmin protein family. Syt1 is an integral membrane protein of synaptic vesicles and it is involved in both endocytosis and exocytosis (1). Syt1 is known to directly interact with the SNARE complex; it contains two C2 domains (C2A and C2B) that are homologous in sequence and 3-D in structure, but have distinct biochemical and biological properties (2). The C2A domain binds Ca2+ thus allowing Syt1 to act as a calcium sensor in the Ca2+-dependent release of neurotransmitter vesicles whereas the C2B domain binds inositol high polyphosphates (2). In vertebrates, Syt1 is required for a type of exocytosis (fast, synchronous release) (1). The intestinal epithelial Syt1 has been shown to play an important role in cAMP-stimulated endocytosis of apical membrane Na(+)-H(+) exchanger (3). Syt1 can also function as a protein receptor for Botulinum neurotoxins (BoNT/B and BoNT/G) (4).
The expression of Syt1 is negatively regulated by Akt (protein kinase B) and inhibition of Akt leads to an increase in the expression of Syt1 genes (5). A high expression of Syt1 is found in the brains of patients with refractory epilepsy (6). Deficiency of Syt1 in mice resulted in their death with 24 hours. These mice also exhibited motor dysfunction, reduction in body weight and growth (7).
Syt1 is expressed throughout the brain, but it is mainly expressed in the cytoplasm and cytomembrane of neurons.
Sty1 is approximately a 50.6kDa protein (422 amino acids).

General readings

Han C., et al. (2009) J. Immunol. 182:2986-2996.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Synaptotagmin pSer309 antibody

Figure 2. Synaptotagmin pSer309 and PSD95 Double-Label Immunostaining of 14 DIV Cortical Neurons. Rabbit IgG Aff - Purified Bov, Can, Chk, Hu, Ms, non-Human Primates, Rt, Ze C, Dot, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Synaptotagmin pThr202 antibody

Figure 2. Synaptotagmin pThr202 and PSD95 Double-Label Immunostaining of 14 DIV Cortical Neurons. Rabbit IgG Aff - Purified Bov, Can, Chk, Hu, Ms, non-Human Primates, Rt, Ze C, Dot, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Synaptotagmin antibody

Immunohistochemical analysis of Synaptotagmin staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Mky, Ms, Rt P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Synaptotagmin antibody

Immunohistochemical analysis of Synaptotagmin staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Mky, Ms, Rt P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Synaptotagmin antibody

Immunohistochemical analysis of Synaptotagmin staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Mky, Ms, Rt P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Synaptotagmin antibody

Western blot analysis of Synaptotagmin expression in HEK293T (A); mouse brain (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Synaptotagmin antibody

Western blot analysis of Synaptotagmin expression in HEK293T (A); mouse brain (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Synaptotagmin antibody

Western blot analysis of Synaptotagmin expression in HEK293T (A); mouse brain (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Synaptotagmin pSer309 antibody

Synaptotagmin Rabbit Hu, Ms, Rt ICC/IF
50 µg / €360.00
  Novus Biologicals Inc.

Synaptotagmin pSer309 antibody

Synaptotagmin Rabbit Hu, Ms, Rt ICC/IF
0.1 mg / €480.00
  Novus Biologicals Inc.

Synaptotagmin 1 + 2 antibody

Western blot analysis of Synaptotagmin 1/2 expression in rat brain extracts (1) and PC12 (2) using AM26691AF-N. Mouse IgG2a 1D12 Azide Free Rt ICC/IF, IP, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

Synaptotagmin-1 antibody

AP16929PU-N SYT1 antibody staining of paraffin embedded Human Brain at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Synaptotagmin-1 antibody

Western blot of rat cortex lysate showing specific labeling of the ~65k synaptotagmin protein. Rabbit IgG Aff - Purified Bov, Chk, Hu, Ms, non-Human Primates, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Synaptotagmin-1 antibody

Western blot analysis of Synaptotagmin expression in Forskolin treated 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Synaptotagmin-1 antibody

Western blot analysis of Synaptotagmin expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Synaptotagmin-1 antibody

Western blot analysis of various cell lines, using SYT1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Synaptotagmin-1 antibody

Western blot analysis of rat brain membranes: 1. Anti-Synaptotagmin-I antibody, (1:200). 2. Anti-Synaptotagmin-I antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Synaptotagmin-1 antibody

Western blot analysis using SYT1 antibody Cat.-No AM06290SU-N against truncated Trx-SYT1 recombinant protein (Lane 1). Mouse IgG1 8G11B10 Ascites Hu WB
0.1 ml / €400.00
  Acris Antibodies GmbH

Synaptotagmin-1 (N-term) antibody

Western blot analysis Synaptotagmin1 expression in rat brain extracts (1) or PC12 (2) using AM26493AF-N. Mouse IgG2a 3F10 Azide Free Rt WB
0.1 mg / €360.00
  Acris Antibodies GmbH

Synaptotagmin-1 antibody

Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 1A6 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

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