Synaptotagmin-3 antibody

Principal name

Synaptotagmin-3 antibody

Alternative names for Synaptotagmin-3 antibody

Synaptotagmin 3, SYT3, SYT-3, Synaptotagmin III, SytIII

SwissProt ID

O35681 (Mouse), P40748 (Rat), Q9BQG1 (Human)

Gene ID

84258 (SYT3), 20981 (Syt3)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Paraffin Sections (P)

Background of Synaptotagmin-3 antibody

Synaptotagmins constitute a family of membranetrafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B. There are 15 members in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, E-Syts, and MCTPs) and soluble (RIMs, Munc13s, synaptotagmin-related proteins and B/K) proteins.
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 (1, 2).
Synaptotagmin-3 may play a role in insulin release in pancreatic βcells, and may also play a role in CXCR4 mediated T-cell migration processes (3).

General readings

Jones JM. et al. (1995) Mamm Genome. 6:212–213.Li C. et al. (1995) Nature. 375:594–599.

11 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Synaptotagmin-3 (442-533, Cytopl. Dom.) antibody

Synaptotagmin-3 Mouse IgG1 S278-19 Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Synaptotagmin-3 antibody

SYT3 antibody - N-terminal region validated by WB using mouse, rat, and human brain lysates at 1 ug/ml. Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Synaptotagmin-3 antibody

Immunofluorescence against SUR1 WT (left) and null mutant (right) mouse striatum and stained with N289/16 (green) and commercial antibody against Tyrosine Hydroxylase (blue). Images courtesy of Paul Witkovsky, Jyoti Patel and Margaret Rice, New York University Medical Center. Mouse IgG1 N278/19 Supernatant Hu, Ms, Rt ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

Synaptotagmin-3 antibody

Immunofluorescence against SUR1 WT (left) and null mutant (right) mouse striatum and stained with N289/16 (green) and commercial antibody against Tyrosine Hydroxylase (blue). Images courtesy of Paul Witkovsky, Jyoti Patel and Margaret Rice, New York University Medical Center. Mouse IgG1 N278/19 Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

Synaptotagmin-3 antibody

mouse, rat, and human brain; SYT3 antibody - N-terminal region (ARP50058_P050) validated by WB using mouse, rat, and human brain lysates at 1ug/ml.; SYT3 antibody - N-terminal region (ARP50058_P050) in mouse, rat, and human brain cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Synaptotagmin-3 antibody

Western Blot: Synaptotagmin 3  Antibody [NBP1-59689] - This Anti-SYT3 antibody was used in Western Blot of 293T tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Synaptotagmin-3

Synaptotagmin-3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Synaptotagmin-3 (transcript variant 2)

Synaptotagmin-3 Human > 80 %
Preparation: or Add: Recombint proteins was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Synaptotagmin-3 (transcript variant 3)

Synaptotagmin-3 Human > 80 %
Preparation: or Add: Recombint proteins was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Synaptotagmin-3 (76-590, His-tag)

Synaptotagmin-3 Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

Synaptotagmin-3 (76-590, His-tag)

Synaptotagmin-3 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

11 Item(s)

per page
  • LinkedIn