Synaptotagmin-7 antibody

Principal name

Synaptotagmin-7 antibody

Alternative names for Synaptotagmin-7 antibody

Synaptotagmin 7, SYT7, SYT-7, Synaptotagmin VII, SytVII, IPCA-7, PCANAP7, Prostate cancer-associated protein 7

SwissProt ID

O43581 (Human), Q9R0N7 (Mouse)

Gene ID

9066 (SYT7), 54525 (Syt7)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Frozen Sections (C)

Background of Synaptotagmin-7 antibody

Synaptotagmins constitute a family of membrane trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B. There are 15 members in the mammalian synaptotagmin family.There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, E-Syts, and MCTPs) and soluble (RIMs, Munc13s, synaptotagmin-related proteins and B/K) proteins. 
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2.
Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

9 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Synaptotagmin-7 antibody

Predicted band size: 46kDa. Positive control: Lncap and SKOV3 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lane1: Lncap cell lysate Lane2: SKOV3 cell lysate Lysates: 40 ug per lane Primary antibody: 1/200 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Synaptotagmin-7 antibody

Predicted band size: 46kDa. Positive control: SKOV3 cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/200 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 5 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Synaptotagmin-7 (150-239, Cytopl. Dom.) antibody

WB of rat brain lysate showing detection of ~65 kDa Synaptotagmin 7 protein using Anti-Synaptotagmin 7.  Lane 1: MW ladder. Lane 2: Anti-Synaptotagmin 7 (1:100). Lane 3: Anti-Synaptotagmin 7 (1:250). Lane 4: Anti-Synaptotagmin 7 (1:500). Lane 5: Anti-Synaptotagmin 7 (1:1000).  Load: 20 µg RB lysate per lane. Block: 5% milk + TBST 1hr at RT. Primary antibody: Mouse Anti-Synaptotagmin 7 monoclonal antibody incubated for 60 min at RT. Secondary antibody: Goat Anti-Mouse HRP antibody at 1:50 for 60 min at RT. Colour Development: TMB solution for 30 min at RT. Predicted/Observed size: ~ 65 kDa. Other band(s) (faint): ~25kDa, ~37kDa, ~100kDa, ~150kDa. Mouse IgG2b S275-14 Purified Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Synaptotagmin-7 antibody

Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged Synaptotagmin or untagged Kv2.1 plasmids and probed with N275/14 (left) and N86/8 (right). Mouse IgG2b N275/14 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

Synaptotagmin-7 antibody

Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged Synaptotagmin or untagged Kv2.1 plasmids and probed with N275/14 (left) and N86/8 (right). Mouse IgG2b N275/14 Purified Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

Synaptotagmin-7 antibody

Synaptotagmin-7 Mouse IgG2a 4H4 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Synaptotagmin-7 antibody

Immunohistochemistry-Paraffin: SYT7 Antibody [NBP1-81588] - Immunohistochemical staining of human kidney shows strong cytoplasmic positivity, with a granular pattern, in cells in tubules. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Synaptotagmin-7

Synaptotagmin-7 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Synaptotagmin-7

Synaptotagmin-7 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

9 Item(s)

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