Synphilin 1 / SNCAIP antibody
Principal name
Synphilin 1 / SNCAIP antibody
Alternative names for Synphilin 1 / SNCAIP antibody
Synphilin-1, Sph1, Alpha-synuclein-interacting protein
Gene ID
9627 (SNCAIP)
Ncbi ID
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C), ELISA (detection) (E(detection))
Background of Synphilin 1 / SNCAIP antibody
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| AP13492PU-N | Synphilin 1 / SNCAIP antibody |
||||||
 |
Rabbit | Ig | Purified | Hu, Ms | E, WB |
0.4 ml /
€370.00
|
|
| Acris Antibodies GmbH | |||||||
| SP1304 | Synphilin 1 / SNCAIP (829-847) antibody |
||||||
 |
Goat | Serum | Hu | P, WB |
0.1 ml /
€450.00
|
||
| Acris Antibodies GmbH | |||||||
CRISPR
| Catalog No. | Species | Donor Vector | |
|---|---|---|---|
| KN222425 | SNCAIP - human gene knockout kit via CRISPR |
||
|
Human | GFP-Puro |
1 kit /
€1,200.00
|
| OriGene Technologies, Inc. | |||
| KN222425BN | SNCAIP - human gene knockout kit via CRISPR |
||
|
Human | mBFP-Neo |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN222425LP | SNCAIP - human gene knockout kit via CRISPR |
||
|
Human | Luciferase-Puro |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN222425RB | SNCAIP - human gene knockout kit via CRISPR |
||
|
Human | RFP-BSD |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP322425 | Synphilin 1 / SNCAIP |
||||
| Recombinant protein of human synuclein, alpha interacting protein (SNCAIP) | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€680.00
|
|
| OriGene Technologies, Inc. | |||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY417299 | SNCAIP overexpression lysate |
|
|
0.1 mg /
€480.00
|
|
| OriGene Technologies, Inc. |
Human Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RC222425L2V | Lenti ORF particles, SNCAIP (mGFP-tagged)-Human synuclein, alpha interacting protein (SNCAIP), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,920.00
|
|
| OriGene Technologies, Inc. | ||
| RC222425L1V | Lenti ORF particles, SNCAIP (Myc-DDK-tagged)-Human synuclein, alpha interacting protein (SNCAIP), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,730.00
|
|
| OriGene Technologies, Inc. | ||
