Syntaxin 1A / STX1A antibody

Principal name

Syntaxin 1A / STX1A antibody

Alternative names for Syntaxin 1A / STX1A antibody

Syntaxin-1A, STX1, Neuron-specific antigen HPC-1

SwissProt ID

O35526 (Mouse), P32850 (Bovin), P32851 (Rat), Q16623 (Human)

Gene ID

116470 (Stx1a), 6804 (STX1A), 20907

Available reactivities

Hu (Human), Por (Porcine), Rt (Rat), Hst (Hamster), Bov (Bovine), Fe (Feline), Ms (Mouse), Xen (Xenopus), Can (Canine), Dros (Drosophila), Ze (Zebrafish), Rb (Rabbit), Mky (Monkey), Chk (Chicken), Eq (Equine)

Available hosts

Mouse, Goat, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Flow Cytometry (F)

Background of Syntaxin 1A / STX1A antibody

Syntaxin 1 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SRE) protein superfamily. The family includes 36 members in humans and is characterized by the SRE motif, an evolutiorily conserved stretch of 60–70 amino acids that are arranged in heptad repeats. SRE proteins are involved in exocytosis and intracellular vesicle trafficking and are essential for cell growth, hormone secretion and neurotransmission, processes that require rapid, targeted, and regulated membrane fusion. SREs can be roughly divided into vesicular (v-SREs) and target (t-SREs) based on their distribution on the transport vesicle or target membrane respectively. Thus, assembly of cogte v-/t-SREs between two opposing membranes generates trans-SRE complexes, which bring the lipid bilayers in close proximity and drive membrane fusion. Syntaxin 1, like most SREs, is a type IV membrane protein with a relatively large N-terminus containing the SRE motif located in the cytoplasmic side and a transmembrane domain located close to the C-terminus that functions as an anchor. Syntaxin 1 has been extensively studied for its role on neurol and neuroendocrine cell exocytosis where it functions as the plasma membrane protein t-SRE, which together with the vesicular v-SRE protein VAMP and the membrane-associated SP-25 (syptosome-associated protein 25 kDa), forms a trimeric, four-helical complex, which drives fusion of the two opposing bilayers. Syntaxin 1 together with SP-25 is the target of the neurotoxin botulinum neurotoxin type C (BoNT/C) which following proteolytic degradation of the proteins causes inhibition of neurotransmitter release .

General readings

1. Pang, Z. P., et al., J. Neurosci. 26, 12556-12565 (2006)
2. Chin, L. S., et al., J. Biol. Chem. 277, 35071-35079 (2002)
3. Graff, L., et al., Cancer Res. 61, 2138-2144 (2001)
4. Foletti, D. L., J. Neurosci. 20, 4535-4544 (2000)
5. Yang, S. N., et al., PNAS 96, 10164-10169 (1999)
6. Galli, T., et al., J. Biol. Chem. 271, 2139-2198 (1996)
Clone HPC-1 is used in these references.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Syntaxin 1A / 1B (STX1A / STX1B) antibody

TA303051 (0.003µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Syntaxin 1A / 1B (STX1A / STX1B) antibody

The STX1A/STX1B2 polyclonal antibody ( Cat # PAB6845 ) ( 0.003 µg/ml ) staining of mouse brain lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Purified Ms E
0.1 mg / €400.00
  Abnova Taiwan Corp.

Syntaxin 1A / STX1A antibody

STX1A MaxPab rabbit polyclonal antibody. Western Blot analysis of STX1A expression in rat brain. Rabbit Serum Hu, Ms, Rt E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

Syntaxin 1A / STX1A antibody

Immunofluorescence of monoclonal antibody to STX1A on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG1 1B11-1A8 Purified Hu, Rt E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Syntaxin 1A / STX1A (N-term) antibody

AM11196PU-N Syntaxin 1A antibody staining of Human Brain. Rabbit SP36 Purified Hu P
0.5 ml / €380.00
  Acris Antibodies GmbH

Syntaxin 1A / STX1A (N-term) antibody

AM11196PU-N Syntaxin 1A antibody staining of Human Brain. Rabbit SP36 Purified Hu P
1 ml / €540.00
  Acris Antibodies GmbH

Syntaxin 1A / STX1A (N-term) antibody

AM11196PU-N Syntaxin 1A antibody staining of Human Brain. Rabbit SP36 Purified Hu P
0.1 ml / €290.00
  Acris Antibodies GmbH

Syntaxin 1A / STX1A antibody

Human Brain stained with Anti-Syntaxin 1A Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

Syntaxin 1A / STX1A antibody

Human Brain stained with Anti-Syntaxin 1A Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

Syntaxin 1A / STX1A antibody

Human Brain stained with Anti-Syntaxin 1A Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

Syntaxin 1A / STX1A antibody

Western blot of rat cortex lysate showing specific immunolabeling of the ~ 36k syntaxin 1A protein. Mouse IgG1 SP8 Purified Hst, Hu, Por, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Syntaxin 1A / STX1A antibody

Predicted band size: 33 kDa. Positive control: Mouse brain tissue lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/350 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Syntaxin 1A / STX1A antibody

Predicted band size: 33 kDa. Positive control: Mouse brain tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/600 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Syntaxin 1A / STX1A antibody

Western blot analysis of Syntaxin 1A expression in HT29 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Syntaxin 1A / STX1A antibody

Western blot analysis of Syntaxin in a rat tissue mix using a 1:1000 dilution of the antibody Mouse IgG1 SP6 Purified Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Syntaxin 1A / STX1A antibody

Western blot analysis of rat brain membranes: 1. Anti-Syntaxin 1 antibody , (1:1000). 2. Anti-Syntaxin 1 antibody, preincubated with the control fusion protein antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Syntaxin 1A / STX1A antibody

WB Suggested Anti-STX1A Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: 721_B cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Syntaxin 1A / STX1A antibody

Anti-STX1A / Syntaxin 1A antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Can, Chk, Eq, Hu
50 µg / €379.00
  OriGene Technologies, Inc.

Syntaxin 1A / STX1A antibody

Anti-STX1A / Syntaxin 1A antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Xen
50 µg / €379.00
  OriGene Technologies, Inc.

Syntaxin 1A / STX1A antibody

Immunohistochemistry: AM05093AF-N Syntaxin-1 antibody staining of Paraffin Embedded Section Human spinal cord. Mouse IgG1 HPC-1 Azide Free Bov, Hu, Ms, Rb, Rt IP, P, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

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