SYPL2 antibody

Principal name

SYPL2 antibody

Alternative names for SYPL2 antibody

Synaptophysin-like protein 2

SwissProt ID

O62646 (Rabit), O89104 (Mouse), Q5VXT5 (Human)

Gene ID

284612 (SYPL2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C)

Background of SYPL2 antibody

SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family. SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle. SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function. Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores. At least two isoforms of SYPL2 are known to exist. SYPL2 antibody will not cross-react with SYPL1.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SYPL2 antibody

Western blot analysis of SYPL2 in human spleen tissue lysate with SYPL2 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SYPL2 (C-term) antibody

Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

SYPL2 Control Peptide

SYPL2
50 µg / €160.00
  Acris Antibodies GmbH

SYPL2 antibody

SYPL2 Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €480.00
  Novus Biologicals Inc.

SYPL2 antibody

Immunohistochemistry-Paraffin: SYPL2 Antibody [NBP1-77362] - Human spleen tissue with SYPL2 antibody at 2.5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

SYPL2 overexpression lysate

SYPL2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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