T Cell Receptor / TCR gamma/delta antibody

Principal name

T Cell Receptor / TCR gamma/delta antibody

Alternative names for T Cell Receptor / TCR gamma/delta antibody

T-Cell Receptor delta, T-Cell Receptor gamma, T-Cell Receptor gamma delta, TCRD, TCRG, TCR gamma, TCR delta

Available reactivities

Ms (Mouse), Rt (Rat), Chk (Chicken), Hu (Human)

Available hosts

Hamster, Mouse

Available applications

Flow Cytometry (F), Frozen Sections (C), Paraffin Sections (P), Immunoprecipitation (IP), Functional assay (FN)

Background of T Cell Receptor / TCR gamma/delta antibody

T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas.

General readings

1. Skarstein, K. et al. (1994) Oligoclonality of T cells in salivary glands of autoimmune MRL/lpr mice. Immunology 81: 497-501.
2. Van der Heyde, H. C. et al. (1995) Gamma/delta T cells function in cell mediated immunity to acute blood-stage plasmodium chabaudi adami Malaria. J. Immunol. 154: 3985 - 3990.
3. Skeen, M. J. and Ziegler, H.K. (1993) Induction of murine peritoneal gamma/delta T cells and their role in resistance to bacterial infection. J. Exp. Med. 178: 971 - 984.
4. Karasova, D. et al. (2010) Influence of 5 major Salmonella pathogenicity islands on NK cell depletion in mice infected with Salmonella enterica serovar Enteritidis.
BMC Microbiol. 10: 75.
5. Kinoshita, N. et al. (2002) Autocrine IL-15 mediates intestinal epithelial cell death via the activation of neighboring intraepithelial NK cells. J Immunol. 169: 6187-92.
6. Laky, K. et al. (2000) Enterocyte expression of interleukin 7 induces development of gammadelta T cells and Peyer's patches. J Exp Med. 191: 1569-80.
7. Skelsey, M.E. et al. (2001) Gamma delta T cells are needed for ocular immune privilege and corneal graft survival. J Immunol. 166: 4327-33.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Hamster IgG UC7-13D5 Biotin Ms F
0.5 mg / €350.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Hamster IgG UC7-13D5 FITC Ms F
0.5 mg / €350.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Hamster IgG UC7-13D5 Low Endotoxin Ms C, F, FN, IP
0.5 mg / €380.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

Immunofluorescent Staining: The T195 T-cell line was first incubated with purified Hamster anti-Mouse TCRgamma/delta and then stained with Mouse anti-Hamster IgG-FITC. Large cells were gated and analyzed by flow cytometry. Amount Used: 3 µg/10e6 cells. Hamster IgG UC7-13D5 Purified Ms C, F, FN, IP
0.5 mg / €290.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Hamster IgG UC7-13D5 PE Ms F
0.2 mg / €300.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Hamster IgG UC7-13D5 PE Ms F
0.1 mg / €230.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Mouse IgG1 TCR1 Biotin Chk F
0.5 mg / €410.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

Immunofluorescent Staining: Chicken PBMC were double stained with Mouse anti-Chicken TCR gamma/delta-FITC and Mouse anti-Chicken CD3-PE. Small lymphocytes were then gated and analyzed on a FACScan(TM) flow cytometer (BDIS, San Jose, CA). Amount Used: 1 µg/10e6 cells. Mouse IgG1 TCR1 FITC Chk F
0.5 mg / €450.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Hamster IgG GL3 Biotin Ms F
0.1 mg / €230.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Hamster IgG GL3 PE-Cy5 Ms F
0.1 mg / €430.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Hamster IgG GL3 FITC Ms F, P
0.1 mg / €290.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Hamster IgG GL3 FITC Ms F, P
25 µg / €190.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Hamster IgG GL3 Purified Ms C, F, IP
0.1 mg / €280.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Hamster IgG GL3 PE Ms F
0.5 ml / €320.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

LFL2 - Cell Source: Splenic T Cells - Percentage of cells stained above control: 5.3% Mouse IgG1 V65 Biotin Rt C, F
0.1 mg / €280.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Mouse IgG1 V65 FITC Rt F
0.1 mg / €440.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Mouse IgG1 V65 Purified Rt C, F, IP
0.25 mg / €440.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Mouse IgG1 V65 Purified Rt C, F, IP
0.1 mg / €270.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Mouse IgG1 V65 PE Rt F
100 Tests / €450.00
  Acris Antibodies GmbH

T Cell Receptor (TCR) gamma/delta antibody

T Cell Receptor (TCR) gamma/delta Mouse IgG1 V65 Purified Rt C, F, IP, P
0.25 mg / €380.00
  Novus Biologicals Inc.

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