t-PA / PLAT antibody

Principal name

t-PA / PLAT antibody

Alternative names for t-PA / PLAT antibody

tPA, Tissue-type plasminogen activator, Alteplase, Reteplase

SwissProt ID

P00750 (Human), P00750-3, P11214 (Mouse), P19637 (Rat), Q28198 (Bovin), Q8MKB1 (Rabit), Q8SQ23 (Pig)

Gene ID

5327 (PLAT), 18791 (Plat), 25692

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Goat, Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Radioimmunoassay (R), Immunoprecipitation (IP)

Background of t-PA / PLAT antibody

TPA converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. TPA binds to fibrin with high affinity; this leads to an increase in the catalytic efficiency of the enzyme of 100- to 1000-fold, due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binding to laminin and fibronectin has also been demonstrated. TPA also binds to mannose receptor and the low density lipoprotein receptor related protein (LRP1). These proteins are involved in TPA clearance. TPA binds to annexin II and to cytokeratin 8. As yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation. Binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

t-PA / PLAT antibody

t-PA / PLAT Goat Serum Hu C, E, P
0.1 ml / €220.00
  Acris Antibodies GmbH

t-PA / PLAT antibody

t-PA / PLAT Goat Serum Hu C, E, P
20 µl / €120.00
  Acris Antibodies GmbH

t-PA / PLAT antibody

  PLAT mouse monoclonal antibody, clone OTI3H3 (formerly 3H3)  
Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-PLAT mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA805448) Mouse IgG2b OTI3H3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

t-PA / PLAT antibody

  Anti-PLAT Rabbit Polyclonal Antibody  
Predicted band size: 63 kDa . Positive control: 231 cell lysate. Recommended dilution: 1/200-1000. (Gel: 8%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/450 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

t-PA / PLAT antibody

  Anti-PLAT Rabbit Polyclonal Antibody  
Predicted band size: 63 kDa . Positive control: 231 cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/350 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 15 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

t-PA / PLAT antibody

  Rabbit anti-PLAT Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using PLAT antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

t-PA / PLAT antibody

  Rabbit Polyclonal Anti-PLAT Antibody - middle region  
WB Suggested Anti-PLAT Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: PANC1 cell lysate Rabbit IgG Purified Can, Eq, GP, Hu, Por, Rb WB
50 µg / €325.00
  OriGene Technologies, Inc.

t-PA / PLAT antibody

t-PA / PLAT Mouse IgG 2A153 Purified Hu E, WB
1 mg / €880.00
  Acris Antibodies GmbH

t-PA / PLAT antibody

t-PA / PLAT Rabbit Purified Hu C, E, WB
0.2 mg / €490.00
  Acris Antibodies GmbH

t-PA / PLAT (Center) antibody

Western blot analysis of TPA Antibody (Center) (AP17801PU-N) in A2058 cell line lysates (35ug/lane). TPA (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PLAT - human gene knockout kit via CRISPR

PLAT - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PLAT - human gene knockout kit via CRISPR

PLAT - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PLAT - human gene knockout kit via CRISPR

PLAT - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PLAT - human gene knockout kit via CRISPR

PLAT - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Plat - mouse gene knockout kit via CRISPR

Plat - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Plat - mouse gene knockout kit via CRISPR

Plat - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Plat - mouse gene knockout kit via CRISPR

Plat - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Plat - mouse gene knockout kit via CRISPR

Plat - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

t-PA / PLAT (transcript variant 3)

  Purified recombinant protein of Homo sapiens plasminogen activator, tissue (PLAT), transcript variant 3  
t-PA / PLAT Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

t-PA / PLAT (transcript variant 3)

  Purified recombinant protein of Human plasminogen activator, tissue (PLAT), transcript variant 3  
t-PA / PLAT Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

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