Tachykinin receptor 1 (TACR1) antibody

Principal name

Tachykinin receptor 1 (TACR1) antibody

Alternative names for Tachykinin receptor 1 (TACR1) antibody

TAC1R, Substance-P receptor, SPR, NK-1 receptor, NK-1R, NK1R

SwissProt ID

P14600 (Rat), P25103 (Human), P30548 (Mouse)

Gene ID

6869 (TACR1), 24807 (Tacr1)

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human), GP (Guinea Pig), Ge (Gerbil), Can (Canine), Chk (Chicken), Bov (Bovine), Eq (Equine), Hst (Hamster), Mky (Monkey), Op (Opossum), Rb (Rabbit), Bt (Bat)

Available hosts

Rabbit, Mouse, Goat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of Tachykinin receptor 1 (TACR1) antibody

The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. Tachykinin receptor 1 consists of 407 amino acid residues, and it has a molecular weight of 58.000. Tachykinin receptor 1, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane (TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for a disulfide bridge, Asp-Arg-Tyr, which is responsible for association with arrestin and, Lys/Arg-Lys/Arg-X-X-Lys/Arg, which interacts with G-proteins.The tachykinin receptor 1 can be found in both the central and peripheral nervous system. It is present in neurons, brainstem, vascular endothelial cells, muscle, gastrointestinal tracts, genitourinary tract, pulmonary tissue, thyroid gland and different types of immune cells. The binding of SP to the tachykinin receptor 1 has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation. Tachykinin receptor 1 antagonists have also been studied in migraine, emesis and psychiatric disorders. In fact, aprepitant has been proved effective in a number of pathophysiological models of anxiety and depression. Other diseases in which the tachykinin receptor 1 system is involved include asthma, rheumatoid arthritis and gastrointestinal disorders.

General readings

Lai JP, Ho WZ, Kilpatrick LE, Wang X, Tuluc F, Korchak HM, Douglas SD.
Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation.
Proc Natl Acad Sci U S A. 2006 May 16;103(20):7771-6. Epub 2006 May 4.
PMID: 16675550

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tachykinin receptor 1 (TACR1) antibody

Western blot analysis of NK-1R antibody (Cat.-No AP01219PU-N) in extracts from Jurkat cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Tachykinin receptor 1 (TACR1) (393-407) antibody

Staining with Neurokinin 1 Receptor Rabbit Antibody (20060) Rabbit Serum Ge, Ms, Rt C, WB
0.1 ml / €430.00
  ImmunoStar Inc.

Tachykinin receptor 1 (TACR1) antibody

  Goat Polyclonal Antibody against TACR1  
TA303231 (1µg/ml) staining of Human Testes lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) antibody

  Rabbit Polyclonal Neurokinin 1 Receptor Antibody  
Western Blot: Neurokinin 1 Receptor Antibody - WB analysis of Neurokinin 1 Receptor in 1. human brain, 2. mouse brain, 3. rat brain and 4. monkey brain. Rabbit Purified GP, Hu, Rt C, F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) antibody

  Rabbit polyclonal NK1R antibody  
Western blot analysis of extracts from Jurkat cells, using NK1R antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) antibody

  Rabbit polyclonal Anti-Neurokinin Receptor 1 (NK1) (extracellular)  
Western blot analysis of rat ovary (lanes 1 and 5), rat brain (lanes 2 and 6), mouse brain membrane (lanes 3 and 7) and SH-SY5Y (lanes 4 and 8) lysate: 1-4. Anti-Neurokinin Receptor 1 (NK1) (extracellular) antibody, (1:200). 5-8. Anti-Neurokinin Receptor 1 (NK1) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) antibody

  Rabbit anti-TACR1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using TACR1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) (2nd Extracell. Dom.) antibody

  Rabbit Polyclonal Anti-TACR1 Antibody (Extracellular Domain)  
Anti-TACR1 /  NK1R antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Can, Elephant, Eq, GP, Hst, Hu, Mky, Ms, Op, Rb, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) (C-term) antibody

  Rabbit Polyclonal Anti-TACR1 Antibody (C-Terminus)  
Anti-Neurokinin 1 Receptor / NK1R antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1-40 ug/ml. Rabbit Aff - Purified Bov, Bt, Can, Elephant, Eq, GP, Hst, Hu, Ms, Rb, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) antibody

  Rabbit Polyclonal Anti-TACR1 Antibody (C-Terminus)  
Anti-Neurokinin 1 Receptor antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €400.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) antibody

Western blot analysis of extracts from Jurkat cells, using NK1R Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

Tachykinin receptor 1 (TACR1) antibody

Western blot analysis of extracts from Jurkat cells, using NK1R Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

Tachykinin receptor 1 (TACR1) antibody

Tachykinin receptor 1 (TACR1) Rabbit Serum Ms, Rt C, ICC/IF
0.1 ml / €330.00
  Neuromics Antibodies

Tachykinin receptor 1 (TACR1) antibody

Neurokinin 1 Receptor staining of brain, basal nucleus of Meynert, neurons.Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g. G-protein coupled activation of phospholipase C). Rabbit Serum Hu, Rt C, F, ICC/IF, WB
0.1 ml / €330.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

TACR1 - human gene knockout kit via CRISPR

TACR1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

TACR1 overexpression lysate

TACR1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

TACR1 overexpression lysate

TACR1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TACR1 (mGFP-tagged) - Human tachykinin receptor 1 (TACR1), transcript variant long, 200 uL, >10^7 TU/mL

Lenti ORF particles, TACR1 (mGFP-tagged) - Human tachykinin receptor 1 (TACR1), transcript variant long, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, TACR1 (Myc-DDK tagged) - Human tachykinin receptor 1 (TACR1), transcript variant long , 200 uL, >10^7 TU/mL

Lenti ORF particles, TACR1 (Myc-DDK tagged) - Human tachykinin receptor 1 (TACR1), transcript variant long , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Tacr1 (GFP-tagged ORF) - Rat tachykinin receptor 1 (Tacr1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Tacr1 (GFP-tagged ORF) - Rat tachykinin receptor 1 (Tacr1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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