Tachykinin receptor 1 (TACR1) antibody

Principal name

Tachykinin receptor 1 (TACR1) antibody

Alternative names for Tachykinin receptor 1 (TACR1) antibody

TAC1R, Substance-P receptor, SPR, NK-1 receptor, NK-1R, NK1R

SwissProt ID

P14600 (Rat), P25103 (Human), P30548 (Mouse)

Gene ID

6869 (TACR1), 24807 (Tacr1)

Available reactivities

Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Hst (Hamster), Hu (Human), Mky (Monkey), Ms (Mouse), Op (Opossum), Rb (Rabbit), Rt (Rat), Bt (Bat), Ge (Gerbil), Chk (Chicken)

Available hosts

Rabbit, Mouse, Goat

Available applications

Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E)

Background of Tachykinin receptor 1 (TACR1) antibody

The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. Tachykinin receptor 1 consists of 407 amino acid residues, and it has a molecular weight of 58.000. Tachykinin receptor 1, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane (TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for a disulfide bridge, Asp-Arg-Tyr, which is responsible for association with arrestin and, Lys/Arg-Lys/Arg-X-X-Lys/Arg, which interacts with G-proteins.The tachykinin receptor 1 can be found in both the central and peripheral nervous system. It is present in neurons, brainstem, vascular endothelial cells, muscle, gastrointestinal tracts, genitourinary tract, pulmonary tissue, thyroid gland and different types of immune cells. The binding of SP to the tachykinin receptor 1 has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation. Tachykinin receptor 1 antagonists have also been studied in migraine, emesis and psychiatric disorders. In fact, aprepitant has been proved effective in a number of pathophysiological models of anxiety and depression. Other diseases in which the tachykinin receptor 1 system is involved include asthma, rheumatoid arthritis and gastrointestinal disorders.

General readings

1. Mantyh, P.W., et al, Inhibition of Hyperalgesia by Ablation of Lamina I Spinal Neurons Expressing the Substance P Receptor. Science. 278: 275-279, 1997.
2. Mantyh, C.R. et al, Substance P Activation of Enteric Neurons in Response to Intraluminal Clostridium difficile Toxin A in the Rat Ileum. Gastroenterology. 111:1272-1280, 1996.
3. Mantyh, P.W. et al, Rapid endocytosis of a G protein-coupled receptor: Substance P-evoked internalization of its receptor in the rat striatum in vivo. PNAS. 92: 2622-2626, 1995.
4. Mantyh, P.W., et al, Receptor Endocytosis and Dendrite Reshaping in Spinal Neurons After Somatosensory Stimulation. Science. 268: 1629-1632, 1995.
5. Mantyh, P.W. et al, Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo. Brain Res. 719: 8-13, 1996.
6. Allen, B.J., et al, Noxious Cutaneous Thermal Stimuli induce a graded release of endogenous substance P in the Spinal Cord: Imaging Peptide Action in vivo. J. of Neuroscience. 17(15): 5921-5927, 1997.
7. Vigna, S.R., et al, Characterization of Antibodies to the Rat Substance P (NK-1) Receptor and to a Chimeric Substance P Receptor Expressed in Mammalian Cells. The J. of Neuroscience. 14(2): 834-845, 1994.
See individual datasheets See individual datasheets.
1. Fong, Angelina Y.., et al. Respiratory: Neurokinin-1 receptor activation in Botzinger complex evokes bradypnoea. 575: 869-885, 2006.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tachykinin receptor 1 (TACR1) antibody

Western blot analysis of NK-1R antibody (Cat.-No AP01219PU-N) in extracts from Jurkat cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Tachykinin receptor 1 (TACR1) (393-407) antibody

Staining with Neurokinin 1 Receptor Rabbit Antibody (20060) Rabbit Serum Ge, Ms, Rt C, WB
0.1 ml / €430.00
  ImmunoStar Inc.

Tachykinin receptor 1 (TACR1) antibody

TA303231 (1µg/ml) staining of Human Testes lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) antibody

Western Blot: Neurokinin 1 Receptor Antibody - WB analysis of Neurokinin 1 Receptor in 1. human brain, 2. mouse brain, 3. rat brain and 4. monkey brain. Rabbit Purified GP, Hu, Rt C, F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) antibody

Western blot analysis of extracts from Jurkat cells, using NK1R antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) antibody

Western blot analysis of rat ovary (lanes 1 and 5), rat brain (lanes 2 and 6), mouse brain membrane (lanes 3 and 7) and SH-SY5Y (lanes 4 and 8) lysate: 1-4. Anti-Neurokinin Receptor 1 (NK1) (extracellular) antibody, (1:200). 5-8. Anti-Neurokinin Receptor 1 (NK1) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) antibody

Western blot analysis of extracts of various cell lines, using TACR1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) (2nd Extracell. Dom.) antibody

Anti-TACR1 /  NK1R antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Can, Elephant, Eq, GP, Hst, Hu, Mky, Ms, Op, Rb, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) (C-term) antibody

Anti-Neurokinin 1 Receptor / NK1R antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1-40 ug/ml. Rabbit Aff - Purified Bov, Bt, Can, Elephant, Eq, GP, Hst, Hu, Ms, Rb, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) antibody

Anti-Neurokinin 1 Receptor antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

Tachykinin receptor 1 (TACR1) antibody

Tachykinin receptor 1 (TACR1) Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Tachykinin receptor 1 (TACR1) antibody

Detection limit for recombinant GST tagged TACR1 is approximately 0.1ng/ml as a capture antibody. Mouse IgG2a 1F7 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Tachykinin receptor 1 (TACR1) antibody

TACR1 polyclonal antibody ( Cat # PAB7270 ) ( 1 µg/ml ) staining of human testis lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Tachykinin receptor 1 (TACR1) antibody

Immunohistochemical staining of Tacr1 on a lamina III neuron in the spinal cord of a rat with Tacr1 polyclonal antibody ( Cat # PAB12008 ). Rabbit GP, Ms, Rt C, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

Tachykinin receptor 1 (TACR1) antibody

Tachykinin receptor 1 (TACR1) Rabbit GP, Hu, Rt C, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

Tachykinin receptor 1 (TACR1) antibody

Western blot analysis of extracts from Jurkat cells, using NK1R Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

Tachykinin receptor 1 (TACR1) antibody

Western blot analysis of extracts from Jurkat cells, using NK1R Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

Tachykinin receptor 1 (TACR1) antibody

Tachykinin receptor 1 (TACR1) Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

Tachykinin receptor 1 (TACR1) antibody

Western blot analysis of Tachykinin Receptor 1 expression in COLO205 (A); mouse brain (B) whole cell lysates. Rabbit Aff - Purified Can, Chk, Hu, Ms, Rt ICC/IF, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Tachykinin receptor 1 (TACR1) antibody

Western blot analysis of Tachykinin Receptor 1 expression in COLO205 (A); mouse brain (B) whole cell lysates. Rabbit Aff - Purified Can, Chk, Hu, Ms, Rt ICC/IF, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

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