Tachykinin receptor 1 (TACR1) antibody
Principal name
Tachykinin receptor 1 (TACR1) antibody
Alternative names for Tachykinin receptor 1 (TACR1) antibody
TAC1R, Substance-P receptor, SPR, NK-1 receptor, NK-1R, NK1R
Ncbi ID
NP_001049.1, 9606, 10116, NP_001049, NP_036799, NM_015727, NM_001058, NP_036799.1, NM_012667
Available reactivities
Available hosts
Available applications
Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E), Paraffin Sections (P)
Background of Tachykinin receptor 1 (TACR1) antibody
The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. Tachykinin receptor 1 consists of 407 amino acid residues, and it has a molecular weight of 58.000. Tachykinin receptor 1, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane (TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for a disulfide bridge, Asp-Arg-Tyr, which is responsible for association with arrestin and, Lys/Arg-Lys/Arg-X-X-Lys/Arg, which interacts with G-proteins.The tachykinin receptor 1 can be found in both the central and peripheral nervous system. It is present in neurons, brainstem, vascular endothelial cells, muscle, gastrointestinal tracts, genitourinary tract, pulmonary tissue, thyroid gland and different types of immune cells. The binding of SP to the tachykinin receptor 1 has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation. Tachykinin receptor 1 antagonists have also been studied in migraine, emesis and psychiatric disorders. In fact, aprepitant has been proved effective in a number of pathophysiological models of anxiety and depression. Other diseases in which the tachykinin receptor 1 system is involved include asthma, rheumatoid arthritis and gastrointestinal disorders.
General readings
Lai JP, Ho WZ, Kilpatrick LE, Wang X, Tuluc F, Korchak HM, Douglas SD.
Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation.
Proc Natl Acad Sci U S A. 2006 May 16;103(20):7771-6. Epub 2006 May 4.
PMID: 16675550


Lane 1: HEK293T whole cell lysate. Lane 2: Raw264.7 whole cell lysate. Lane 3 : H9C2 whole cell lysate.














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Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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AP01219PU-N | Tachykinin receptor 1 (TACR1) antibody |
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Rabbit | Aff - Purified | Hu, Ms, Rt | ICC/IF, WB |
0.1 mg /
€350.00
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Acris Antibodies GmbH | |||||||
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Published recently! |
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20060 | Tachykinin receptor 1 (TACR1) (393-407) antibody |
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Rabbit | Serum | Ge, Ms, Rt | C, WB |
0.1 ml /
€430.00
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ImmunoStar Inc. | |||||||
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Highly validated antibody! |
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TA303231 | Tachykinin receptor 1 (TACR1) antibody |
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Goat Polyclonal Antibody against TACR1 | |||||||
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Goat | Aff - Purified | Can, Hu, Ms, Rt | WB |
0.1 mg /
€360.00
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OriGene Technologies, Inc. | |||||||
TA309893 | Tachykinin receptor 1 (TACR1) antibody |
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Rabbit Polyclonal Neurokinin 1 Receptor Antibody | |||||||
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Rabbit | Purified | GP, Hu, Rt | C, F, ICC/IF, WB |
0.1 ml /
€474.00
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OriGene Technologies, Inc. | |||||||
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TA326148 | Tachykinin receptor 1 (TACR1) antibody |
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Rabbit polyclonal NK1R antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
TA329063 | Tachykinin receptor 1 (TACR1) antibody |
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Rabbit polyclonal Anti-Neurokinin Receptor 1 (NK1) (extracellular) | |||||||
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Rabbit | Purified | Hu, Ms, Rt | WB |
0.2 ml /
€622.00
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OriGene Technologies, Inc. | |||||||
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TA332770 | Tachykinin receptor 1 (TACR1) antibody |
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Rabbit anti-TACR1 Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt |
0.1 mg /
€335.00
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OriGene Technologies, Inc. | |||||||
TA340476 | Tachykinin receptor 1 (TACR1) (2nd Extracell. Dom.) antibody |
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Rabbit Polyclonal Anti-TACR1 Antibody (Extracellular Domain) | |||||||
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Rabbit | Aff - Purified | Bov, Can, Elephant, Eq, GP, Hst, Hu, Mky, Ms, Op, Rb, Rt | P |
50 µg /
€400.00
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OriGene Technologies, Inc. | |||||||
TA340810 | Tachykinin receptor 1 (TACR1) (C-term) antibody |
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Rabbit Polyclonal Anti-TACR1 Antibody (C-Terminus) | |||||||
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Rabbit | Aff - Purified | Bov, Bt, Can, Elephant, Eq, GP, Hst, Hu, Ms, Rb, Rt | P |
50 µg /
€400.00
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OriGene Technologies, Inc. | |||||||
TA340811 | Tachykinin receptor 1 (TACR1) antibody |
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Rabbit Polyclonal Anti-TACR1 Antibody (C-Terminus) | |||||||
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Rabbit | Purified | Hu |
50 µg /
€400.00
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OriGene Technologies, Inc. | |||||||
G402-1 | Tachykinin receptor 1 (TACR1) antibody |
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Rabbit | Aff - Purified | Hu, Ms, Rt | E, WB |
50 µg /
€230.00
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Assay Biotech | |||||||
G402-2 | Tachykinin receptor 1 (TACR1) antibody |
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Rabbit | Aff - Purified | Hu, Ms, Rt | E, WB |
0.1 mg /
€330.00
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Assay Biotech | |||||||
RA25001-100 | Tachykinin receptor 1 (TACR1) antibody |
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Rabbit | Serum | Ms, Rt | C, ICC/IF |
0.1 ml /
€330.00
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Neuromics Antibodies | |||||||
RA25003-100 | Tachykinin receptor 1 (TACR1) antibody |
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Rabbit | Serum | Hu, Rt | C, F, ICC/IF, WB |
0.1 ml /
€330.00
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Neuromics Antibodies |
CRISPR
Catalog No. | Species | Donor Vector | |
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KN210395RB | TACR1 - human gene knockout kit via CRISPR |
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Human | RFP-BSD |
1 kit /
€1,290.00
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OriGene Technologies, Inc. |
Lysates
Catalog No. | ||
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LY414361 | TACR1 overexpression lysate |
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0.1 mg /
€295.00
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OriGene Technologies, Inc. | ||
LY420738 | TACR1 overexpression lysate |
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0.1 mg /
€295.00
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OriGene Technologies, Inc. |
Human Lenti ORF Particles
Catalog No. | ||
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RC210395L2V | Lenti ORF particles, TACR1 (mGFP-tagged) - Human tachykinin receptor 1 (TACR1), transcript variant long, 200 uL, >10^7 TU/mL |
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200 µl /
€1,082.00
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OriGene Technologies, Inc. | ||
RC210395L1V | Lenti ORF particles, TACR1 (Myc-DDK tagged) - Human tachykinin receptor 1 (TACR1), transcript variant long , 200 uL, >10^7 TU/mL |
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200 µl /
€969.00
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OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
Catalog No. | ||
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RR203988L2V | Lenti ORF particles, Tacr1 (GFP-tagged ORF) - Rat tachykinin receptor 1 (Tacr1), 200 uL, >10^7 TU/mL |
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200 µl /
€907.00
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OriGene Technologies, Inc. | ||