TAK1 / MAP3K7 antibody

Principal name

TAK1 / MAP3K7 antibody

Alternative names for TAK1 / MAP3K7 antibody

TAK1, TGF-beta-activated kinase 1, TAK-1, Transforming growth factor-beta-activated kinase 1, Mitogen-activated protein kinase kinase kinase 7

SwissProt ID

A2VDU3 (Bovin), O43318 (Human), P0C8E4 (Rat), Q62073 (Mouse), Q9V3Q6 (Drome)

Gene ID

6885 (MAP3K7), 39659 (Tak1), 313121 (Map3k7)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Dros (Drosophila), Hst (Hamster)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Dot blot (Dot), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of TAK1 / MAP3K7 antibody

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.

General readings

Omori E, Matsumoto K, Sanjo H, Sato S, Akira S, Smart RC, Ninomiya-Tsuji J. , TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis. ,J Biol Chem. 2006 May 4; [Epub ahead of print] , PMID: 16675448

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TAK1 / MAP3K7 antibody

Western blot analysis of MAP3K7 over-expressed 293 cell line, cotransfected with MAP3K7 Validated Chimera RNAi ( Cat # H00006885-R02V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with MAP3K7 monoclonal antibody (M02) clone 2E10 (Cat # H00006885-M02 ). GAPDH ( 36.1 kDa ) used as specificity and loading control. Mouse IgG1 2E10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TAK1 / MAP3K7 antibody

TA303111 (1µg/ml) staining of HeLa cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TAK1 / MAP3K7 (N-term) antibody

Western blot analysis of TAK1 in Rat thymus cell lysate with TAK1 antibody at (A) 1, (B) 2, and (C) 4 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TAK1 / MAP3K7 antibody

Western blot analysis of extracts from Jurkat cells, treated with heat shock, using MAP3K7 (Ab-187) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TAK1 / MAP3K7 antibody

Western blot analysis of MAP3K7 expression in Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TAK1 / MAP3K7 antibody

Western blot analysis of extracts from HeLa cells, using MAP2K7 (Ab-271) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TAK1 / MAP3K7 antibody

Western blot analysis of extracts from HepG2 cells, using TAK1 (Ab-184) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TAK1 / MAP3K7 antibody

Western blot (WB) analysis of Tak1 antibody (Cat.-No.: AP06625PU-N) at 1/500 dilution Lane1: Hela whole cell lysate Lane2: MCF-7 whole cell lysate Lane3: Mouse liver tissue lysate Lane4: Rat liver tissue lysate Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TAK1 / MAP3K7 (Isoform a) antibody

Thymus: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TAK1 / MAP3K7 pThr187 antibody

Dot blot analysis of Phospho-MAP3K7-Thr187 polyclonal antibody (Cat#AP12775PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentration were 0.5ug per ml. Rabbit Ig Aff - Purified Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

TAK1 / MAP3K7 pSer192 antibody

Dot blot analysis of Phospho-MAP3K7-Ser192 polyclonal antibody (Cat.-No AP12796PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentration was 0.5 µg per ml. 
P-Pab: Phospho-antibody. 
P-Peptide: Phospho-peptide. 
NP-Peptide: Non-Phospho-peptide. Rabbit Ig Aff - Purified Bov, Hu, Ms, Rt Dot
0.4 ml / €370.00
  Acris Antibodies GmbH

TAK1 / MAP3K7 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TAK1 / MAP3K7 (563-579) antibody

Tonsil, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Bov, Can, GP, Hst, Hu, Mky, Ms, Por, Rb, Rt, Sh, Xen P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TAK1 / MAP3K7 Control Peptide

TAK1 / MAP3K7
50 µg / €160.00
  Acris Antibodies GmbH

TAK1 / MAP3K7 antibody

Human Colon, Ganglion: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TAK1 / MAP3K7 pThr187 antibody

Western blot analysis of extracts from NIH-3T3 tissue using MAP3K7 (Phospho-Thr187) antibody AP55856PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €340.00
  Acris Antibodies GmbH

TAK1 / MAP3K7 pThr187 antibody

Western blot analysis of extracts from NIH-3T3 tissue using MAP3K7 (Phospho-Thr187) antibody AP55856PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €270.00
  Acris Antibodies GmbH

TAK1 / MAP3K7 antibody

Western Blot analysis of MAP3K7 expression in transfected 293T cell line (H00006885-T01) by MAP3K7 MaxPab polyclonal antibody.

Lane 1: MAP3K7 transfected lysate(63.69 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

TAK1 / MAP3K7 antibody

Western Blot analysis of MAP3K7 expression in transfected 293T cell line (H00006885-T01) by MAP3K7 MaxPab polyclonal antibody.

Lane 1: MAP3K7 transfected lysate(63.69 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

TAK1 / MAP3K7 antibody

TAK1 / MAP3K7 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

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