Talin-1 (TLN1) antibody

Principal name

Talin-1 (TLN1) antibody

Alternative names for Talin-1 (TLN1) antibody

KIAA1027, TLN

SwissProt ID

P26039 (Mouse), P54939 (Chick), Q9Y490 (Human)

Gene ID

7094 (TLN1), 395194

Available reactivities

Amph (Amphibian), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Xen (Xenopus), Rb (Rabbit), Bov (Bovine), Can (Canine), Frog, Por (Porcine), Ze (Zebrafish)

Available hosts

Mouse, Rabbit, Goat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F)

Background of Talin-1 (TLN1) antibody

Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-235 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin. Talin and vinculin have been shown to interact with each other and both have been proposed to be involved in generating the transmembrane connection, between the extracellular matrix and the cytoskeleton, that occurs at adhesion plaques. At physiological ionic strength, talin is an elongate, flexible, monomeric protein with the ability to self-associate into dimers at higher protein concentrations. Talin 2 is related to talin 1. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton.

General readings

General / background references:Otey C et al. Characterization of monoclonal antibodies to chicken gizzard talin. Hybridoma 9:57-62 (1990). PubMed PMID: 1690175
Beckerle MC & Yeh RK Talin: role at sites of cell-substratum adhesion. Cell Motil Cytoskeleton 16:7-13 (1990). PubMed PMID: 2112987
Fath KR et al. The distribution of distinct integrins in focal contacts is determined by the substratum composition. J Cell Sci 92 ( Pt 1):67-75 (1989). PubMed PMID: 2476453
Volberg T et al. Spatial and temporal relationships between vinculin and talin in the developing chicken gizzard smooth muscle. Differentiation 32:34-43 (1986). PubMed PMID: 3096800
Burridge K & Connell L Talin: a cytoskeletal component concentrated in adhesion plaques and other sites of actin-membrane interaction. Cell Motil 3:405-17 (1983). PubMed PMID: 6319001

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Talin-1 (TLN1) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG3 1A11 Hu, Ms, Rt E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Talin-1 (TLN1) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG3 5C1 Hu, Ms, Rt E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Talin-1 (TLN1) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG3 2E10 Hu, Ms, Rt E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Talin-1 (TLN1) antibody

Immunoperoxidase of monoclonal antibody to TLN1 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml] Mouse IgG3 1A11 Purified Hu, Ms, Rt E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Talin-1 (TLN1) antibody

Immunoperoxidase of monoclonal antibody to TLN1 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml] Mouse IgG3 5C1 Purified Hu, Ms, Rt E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Talin-1 (TLN1) antibody

Immunoperoxidase of monoclonal antibody to TLN1 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml] Mouse IgG3 2E10 Purified Hu, Ms, Rt E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Talin-1 (TLN1) antibody

TA305932 (1ug/ml) staining of Human Peripheral Mononucleocytes lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Talin-1 (TLN1) antibody

Talin-1 (TLN1) Mouse IgG1 Tal-33 Purified Chk, Frog, Hu, Ms, Rt WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Talin-1 (TLN1) antibody

Talin-1 (TLN1) Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Talin-1 (TLN1) antibody

Talin-1 (TLN1) Mouse IgG3 5D1 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Talin-1 (TLN1) antibody

Talin-1 (TLN1) Mouse IgG3 5D9 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Talin-1 (TLN1) antibody

Talin-1 (TLN1) Mouse IgG1 8B11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Talin-1 (TLN1) antibody

Talin-1 (TLN1) Mouse IgG2a 1H7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Talin-1 (TLN1) antibody

Talin-1 (TLN1) Mouse IgG2b 1A5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Talin-1 (TLN1) antibody

Talin-1 (TLN1) Mouse IgG1 4G4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Talin-1 (TLN1) antibody

Talin-1 (TLN1) Mouse IgG2a 4C8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Talin-1 (TLN1) antibody

Talin-1 (TLN1) Mouse IgM 2B11 Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

Talin-1 (TLN1) antibody

Talin-1 (TLN1) Mouse IgG1 Tal-33 Ascites Chk, Frog, Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

Talin-1 (TLN1) antibody

Western blot analysis of Talin 1 expression in Jurkat (A); K562 (B) whole cell lysates. Rabbit Aff - Purified Chk, Hu, Ms, Por, Ze WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Talin-1 (TLN1) antibody

Western blot analysis of Talin 1 expression in Jurkat (A); K562 (B) whole cell lysates. Rabbit Aff - Purified Chk, Hu, Ms, Por, Ze WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Items 1 to 20 of 39 total

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