TANK / ITRAF antibody

Principal name

TANK / ITRAF antibody

Alternative names for TANK / ITRAF antibody

I-TRAF, TRAF2, TRAF-interacting protein, TRAF family member-associated NF-kappa-B activator

SwissProt ID

P70347 (Mouse), Q92844 (Human)

Gene ID

10010 (TANK)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Rb (Rabbit), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Mouse, Chicken

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), EPair for Elisa (EPair)

Background of TANK / ITRAF antibody

The tumor necrosis factor (TNF) receptor superfamily is composed of several type I integral membrane glycoproteins that exhibit homology in their cystine- rich extracellular domains. Members of this family include TNF-RI and -RII, FAS, OX40, CD27, CD30 and CD40. Ligands for these receptors can be small, secreted proteins such as TNF, or type II integral membrane proteins, such as the CD40 ligand, CD40L. While the signal transduction mechanism of the TNF receptor superfamily is poorly understood, stimulation of cells with either TNF or soluble CD40L has been shown to induce the nuclear translocation of NFkappaB. Members of the TRAF family associate with activated TNF-R and CD40 and have been implicated in this process. The discovery of a novel protein, designated TANK, has shed light on the means by which TRAF activation of NFkB occurs. TANK is not only capable of binding to all three TRAFs, but also of synergizing with TRAF2 to activate the NFkappaB signaling cascade. TANK contains a regulatory carboxy terminal domain that maintains its inactivity in unstimulated cells. Upon its association with TRAF2, the inhibitory effect of this domain is overcome .

General readings

Chung J Y., et al. (2002) J Cell Sci. 115:679-688.Rothe M., et al. (1996) Proc Natl Acad Sci USA. 93:8241-8846.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TANK / ITRAF (C-term) antibody

Western blot analysis of TANK in Daudi cell lysate with TANK antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TANK / ITRAF (N-term) antibody

Western blot analysis of TANK in Daudi cell lysate with TANK antibody at (A) 0.5 and (B) 1 ug/mL. Rabbit IgG Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TANK / ITRAF antibody

WB Suggested Anti-TANK Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TANK / ITRAF antibody

WB Suggested Anti-TANK Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: 293T cell lysate; There is BioGPS gene expression data showing that TANK is expressed in HEK293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TANK / ITRAF Control Peptide

TANK / ITRAF Purified
50 µg / €190.00
  Acris Antibodies GmbH

TANK / ITRAF antibody

Western blot analysis of TANK with mouse small intestine tissue lysate. Rabbit Purified Hu, Ms, Rt IP, P, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

TANK / ITRAF antibody

Western blot analysis of TANK antibody (Cat.-No. AP06800PU-N) in extracts from raw264.7 cells at 1/500 dilution. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TANK / ITRAF antibody

Heart: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TANK / ITRAF antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Kidney. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TANK / ITRAF Control Peptide

TANK / ITRAF
50 µg / €160.00
  Acris Antibodies GmbH

TANK / ITRAF Control Peptide

TANK / ITRAF
50 µg / €160.00
  Acris Antibodies GmbH

TANK / ITRAF antibody

TANK / ITRAF Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

TANK / ITRAF antibody

Western Blot analysis of TANK expression in transfected 293T cell line (H00010010-T01) by TANK MaxPab polyclonal antibody.

Lane1:TANK transfected lysate(13.2 KDa).
Lane 2:Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

TANK / ITRAF antibody

Western Blot analysis of TANK expression in transfected 293T cell line (H00010010-T02) by TANK MaxPab polyclonal antibody.

Lane 1: TANK transfected lysate(13.09 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

TANK / ITRAF antibody

TANK MaxPab rabbit polyclonal antibody. Western Blot analysis of TANK expression in human liver. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

TANK / ITRAF antibody

Immunohistochemical analysis of TANK expression in formalin-fixed, paraffin-embedded normal human colon. Using TANK polyclonal antibody ( Cat # PAB0259 ) at 1 : 2000. A-A3, low and high magnification images. Hematoxylin-eosin counterstain. Rabbit Hu C, IP, P
50 µl / €390.00
  Abnova Taiwan Corp.

TANK / ITRAF antibody

Western blot analysis of TANK with mouse small intestine tissue lysate. Rabbit Hu, Ms, Rt C, IP, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

TANK / ITRAF antibody

Immunohistochemistry of TANK in rat spleen tissue with TANK polyclonal antibody ( Cat # PAB13213 ) at 10 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

TANK / ITRAF antibody

Western blot analysis of TANK in Daudi cell lysate with TANK polyclonal antibody ( Cat # PAB13214 ) at ( A ) 0.5 and ( B ) 1 µg/ml. Rabbit Hu WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

TANK / ITRAF antibody

Human Jurkat; WB Suggested Anti-TANK Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Jurkat cell lysate; TANK antibody - C-terminal region (ARP38420_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

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