TANK / ITRAF antibody

Principal name

TANK / ITRAF antibody

Alternative names for TANK / ITRAF antibody

I-TRAF, TRAF2, TRAF-interacting protein, TRAF family member-associated NF-kappa-B activator

SwissProt ID

P70347 (Mouse), Q92844 (Human)

Gene ID

10010 (TANK), 21353 (Tank)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Rb (Rabbit), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), EPair for Elisa (EPair)

Background of TANK / ITRAF antibody

The tumor necrosis factor (TNF) receptor superfamily is composed of several type I integral membrane glycoproteins that exhibit homology in their cystine- rich extracellular domains. Members of this family include TNF-RI and -RII, FAS, OX40, CD27, CD30 and CD40. Ligands for these receptors can be small, secreted proteins such as TNF, or type II integral membrane proteins, such as the CD40 ligand, CD40L. While the signal transduction mechanism of the TNF receptor superfamily is poorly understood, stimulation of cells with either TNF or soluble CD40L has been shown to induce the nuclear translocation of NFκB. Members of the TRAF family associate with activated TNF-R and CD40 and have been implicated in this process. The discovery of a novel protein, designated TANK, has shed light on the means by which TRAF activation of NFkB occurs. TANK is not only capable of binding to all three TRAFs, but also of synergizing with TRAF2 to activate the NFκB signaling cascade. TANK contains a regulatory carboxy terminal domain that maintains its inactivity in unstimulated cells. Upon its association with TRAF2, the inhibitory effect of this domain is overcome.

General readings

Chung J Y., et al. (2002) J Cell Sci. 115:679-688.Rothe M., et al. (1996) Proc Natl Acad Sci USA. 93:8241-8846.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TANK / ITRAF (C-term) antibody

  Rabbit Polyclonal TANK Antibody  
Western blot analysis of TANK in Daudi cell lysate with TANK antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TANK / ITRAF (N-term) antibody

  Rabbit Polyclonal TANK Antibody  
Western blot analysis of TANK in Daudi cell lysate with TANK antibody at (A) 0.5 and (B) 1 ug/mL. Rabbit IgG Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TANK / ITRAF antibody

  Rabbit Polyclonal anti-TANK Antibody  
Host: Rabbit; Target Name: TANK; Sample Tissue: Lung Tumor lysates; Antibody Dilution: 1.0ug/ml Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

TANK / ITRAF antibody

  Rabbit Polyclonal Anti-TANK Antibody  
WB Suggested Anti-TANK Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TANK / ITRAF antibody

  Rabbit Polyclonal Anti-TANK Antibody  
WB Suggested Anti-TANK Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: 293T cell lysate; There is BioGPS gene expression data showing that TANK is expressed in HEK293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TANK / ITRAF Control Peptide

TANK / ITRAF Purified
50 µg / €190.00
  Acris Antibodies GmbH

TANK / ITRAF antibody

Western blot analysis of TANK with mouse small intestine tissue lysate. Rabbit Purified Hu, Ms, Rt IP, P, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

TANK / ITRAF antibody

Western blot analysis of TANK antibody (Cat.-No. AP06800PU-N) in extracts from raw264.7 cells at 1/500 dilution. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TANK / ITRAF antibody

Heart: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TANK / ITRAF antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Kidney. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

TANK - human gene knockout kit via CRISPR

TANK - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TANK - human gene knockout kit via CRISPR

TANK - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TANK - human gene knockout kit via CRISPR

TANK - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TANK - human gene knockout kit via CRISPR

TANK - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tank - mouse gene knockout kit via CRISPR

Tank - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Tank - mouse gene knockout kit via CRISPR

Tank - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tank - mouse gene knockout kit via CRISPR

Tank - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tank - mouse gene knockout kit via CRISPR

Tank - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TANK / ITRAF (transcript variant 1)

  Recombinant protein of human TRAF family member-associated NFKB activator (TANK), transcript variant 1  
TANK / ITRAF Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

TANK / ITRAF (Isoform "Short" ) (1-119)

TANK / ITRAF Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €680.00
  Acris Antibodies GmbH

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