Tankyrase-1 (TANK1) antibody

Principal name

Tankyrase-1 (TANK1) antibody

Alternative names for Tankyrase-1 (TANK1) antibody

Tankyrase I, TNKS-1, TNKS1, TNKS, PARP5A, PARPL, TIN1, TINF1, TRF1-interacting ankyrin-related ADP-ribose polymerase

SwissProt ID

O95271 (Human)

Gene ID

8658 (TNKS)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Tankyrase-1 (TANK1) antibody

Tankyrase is a protein with homology to ankyrins as well as to the catalytic domain of poly (adenosine diphosphate ribose) polymerase (PARP). Tankyrase localizes to telomeres by binding to the telomeric repeat binding factor 1 (TRF1) through its ankyrin repeats. TRF1 is a negative regulator of telomere length maintenance. Tankyrase exhibits PARP activity functioning as acceptors for adenosine diphosphate (ADP) ribosylation. Since ADP ribosylation of TRF1 diminishes its ability to bind to telomeric DNA, this suggests that telomere function in human cells is regulated by poly (ADP) ribosylation. Both the cell cycle and TRF1 may regulate the subcellular localization of tankyrase. During interphase tankyrase colocalizes with TRF1 to telomeres plus nuclear pore complexes whereas during mitosis tankyrase localizes around the pericentriolar matrix of mitotic chromosomes.
Tankyrase may regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4 vesicles.

General readings

Seimiya H, Muramatsu Y, Ohishi T, Tsuruo T.
Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.
Cancer Cell. 2005 Jan;7(1):25-37.
PMID: 15652747.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tankyrase-1 (TANK1) (N-term) antibody

HEK293 overexpressing TANK1 (lane 2) and TANK2 (lane 4) and probed with TA305803 (mock transfection in first lane). Lane three is empty. For full caption: see Application Notes. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tankyrase-1 (TANK1) antibody

WB Suggested Anti-TNKS Antibody Titration: 1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Tankyrase-1 (TANK1) antibody

WB Suggested Anti-TNKS Antibody Titration: 1 ug/ml; Positive Control: 721_B cell lysateTNKS is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Tankyrase-1 (TANK1) (N-term) antibody

TNKS Antibody (N-term) (AP54320PU-N) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the TNKS antibody detected the TNKS protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Tankyrase-1 (TANK1) antibody

Tankyrase-1 (TANK1) Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Tankyrase-1 (TANK1) antibody

Immunoperoxidase of monoclonal antibody to TNKS on formalin-fixed paraffin-embedded human lymph node. [antibody concentration 3 ug/ml] Mouse IgG2a 1A2 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Tankyrase-1 (TANK1) antibody

Detection limit for recombinant GST tagged TNKS is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 1A3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Tankyrase-1 (TANK1) antibody

Western blot analysis of TNKS in DU145 whole cell lysates ( 50 µg ) with TNKS polyclonal antibody ( Cat# PAB11996 ). ( Lane 1, 1 : 500 antibody dilution. Lane 2, 1 : 2,000 antibody dilution.) Rabbit Hu WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

Tankyrase-1 (TANK1) antibody

Human Small intestine; Immunohistochemistry with Small Intestine, submucosal plexus tissue at an antibody concentration of 5.0ug/ml using anti-TNKS antibody (ARP33755_P050); TNKS antibody - middle region (ARP33755_P050) in Human Small intestine cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

Tankyrase-1 (TANK1) antibody

Human HepG2; HepG2; TNKS antibody - middle region (ARP33756_P050) in Human HepG2 cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Tankyrase-1 (TANK1)

Tankyrase-1 (TANK1) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Tankyrase-1 (TANK1)

Tankyrase-1 (TANK1) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TNKS (mGFP-tagged)-Human tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (TNKS), 200 uL, >10^7 TU/mL

Lenti ORF particles, TNKS (mGFP-tagged)-Human tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (TNKS), 200 uL, >10^7 TU/mL  
200 µl / €2,530.00
  OriGene Technologies, Inc.

Lenti ORF particles, TNKS (Myc-DDK-tagged)-Human tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (TNKS), 200 uL, >10^7 TU/mL

Lenti ORF particles, TNKS (Myc-DDK-tagged)-Human tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (TNKS), 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

14 Item(s)

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