Tankyrase-1 (TANK1) antibody

Principal name

Tankyrase-1 (TANK1) antibody

Alternative names for Tankyrase-1 (TANK1) antibody

Tankyrase I, TNKS-1, TNKS1, TNKS, PARP5A, PARPL, TIN1, TINF1, TRF1-interacting ankyrin-related ADP-ribose polymerase

SwissProt ID

O95271 (Human)

Gene ID

8658 (TNKS)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Por (Porcine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Tankyrase-1 (TANK1) antibody

Tankyrase-1 and the closely related homolog Tankyrase-2 arepoly(ADP-ribose) polymerases (PARPs) that co-localize and use an ankyrin-repeat domain to bind diverse proteins, including TRF-1 (telomere-repeat-binding factor 1), IRAP (insulin-responsive aminopeptidase) and TAB182. Tankyrase-1 (also known as TNKS and TNKS1) and Tankyrase-2 (also known as TNKS2, TNKL and TANK2) interact with the same set of proteins and probably mediate overlapping functions, both at telomeres and in vesicular compartments. Overexpression of Tankyrase-1 in the nucleus promotes telomere elongation, suggesting that Tankyrase 1 may regulate access of telomerase to the telomeric complex. Overexpression of Tankyrase-2 in the nucleus releases endogenous TRF1 from telomeres, establishing Tankyrase-2 as a PARP with itself and TRF1 as acceptors of ADP-ribosylation, and suggesting the possibility of a role for Tankyrase-2 at telomeres. The ankyrin (ANK) domain of Tankyrase-2 comprises five subdomains that provide redundant binding sites for IRAP. Tankyrase-2 lacks the N-terminal Histidine/Proline/Serine-rich region of Tankyrase-1, but contains a corresponding ankyrin repeat region, sterile ?motif module and poly(ADP-ribose) polymerase homology domain. The gene encoding Tankyrase-2 is widely expressed, with mRNA transcripts particularly abundant in skeletal muscle and placenta.

General readings

Seimiya H, Muramatsu Y, Ohishi T, Tsuruo T.
Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.
Cancer Cell. 2005 Jan;7(1):25-37.
PMID: 15652747.

19 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tankyrase-1 (TANK1) (N-term) antibody

HEK293 overexpressing TANK1 (lane 2) and TANK2 (lane 4) and probed with TA305803 (mock transfection in first lane). Lane three is empty. For full caption: see Application Notes. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tankyrase-1 (TANK1) antibody

WB Suggested Anti-TNKS Antibody Titration: 1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Tankyrase-1 (TANK1) antibody

WB Suggested Anti-TNKS Antibody Titration: 1 ug/ml; Positive Control: 721_B cell lysateTNKS is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Tankyrase-1 (TANK1) (N-term) antibody

TNKS Antibody (N-term) (AP54320PU-N) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the TNKS antibody detected the TNKS protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Tankyrase-1 (TANK1) antibody

Tankyrase-1 (TANK1) Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Tankyrase-1 (TANK1) antibody

Immunoperoxidase of monoclonal antibody to TNKS on formalin-fixed paraffin-embedded human lymph node. [antibody concentration 3 ug/ml] Mouse IgG2a 1A2 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Tankyrase-1 (TANK1) antibody

Detection limit for recombinant GST tagged TNKS is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 1A3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Tankyrase-1 (TANK1) antibody

Western blot analysis of TNKS in DU145 whole cell lysates ( 50 µg ) with TNKS polyclonal antibody ( Cat# PAB11996 ). ( Lane 1, 1 : 500 antibody dilution. Lane 2, 1 : 2,000 antibody dilution.) Rabbit Hu WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

Tankyrase-1 (TANK1) antibody

Human Small intestine; Immunohistochemistry with Small Intestine, submucosal plexus tissue at an antibody concentration of 5.0ug/ml using anti-TNKS antibody (ARP33755_P050); TNKS antibody - middle region (ARP33755_P050) in Human Small intestine cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

Tankyrase-1 (TANK1) antibody

Human HepG2; HepG2; TNKS antibody - middle region (ARP33756_P050) in Human HepG2 cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

Tankyrase-1 (TANK1) antibody

Western Blot: Tankyrase Antibody [NB100-186] - Detection of tankyrase in DU145 whole cell lysates (50 ug) using NB 100-186. ECL detection - 30 seconds. Lane 1 - 1:500 primary dilution Lane 2 - 1:2,000 primary dilution Rabbit Aff - Purified Hu WB
0.1 ml / €360.00
  Novus Biologicals Inc.

Tankyrase-1 (TANK1) antibody

Tankyrase-1 (TANK1) Rabbit Biotin Hu WB
0.1 ml / €360.00
  Novus Biologicals Inc.

Tankyrase-1 (TANK1) antibody

Tankyrase-1 (TANK1) Rabbit DyLight488 Hu WB
0.1 ml / €390.00
  Novus Biologicals Inc.

Tankyrase-1 (TANK1) antibody

Tankyrase-1 (TANK1) Rabbit HRP Hu WB
0.1 ml / €380.00
  Novus Biologicals Inc.

Tankyrase-1 (TANK1) Control Peptide

Tankyrase-1 (TANK1)
50 µg / €140.00
  Novus Biologicals Inc.

Tankyrase-1 (TANK1) antibody

Tankyrase-1 (TANK1) Rabbit Aff - Purified Hu WB
25 µl / €160.00
  Novus Biologicals Inc.

Tankyrase-1 (TANK1) antibody

Tankyrase-1 (TANK1) Goat IgG Hu WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Tankyrase-1 (TANK1)

Tankyrase-1 (TANK1) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Tankyrase-1 (TANK1)

Tankyrase-1 (TANK1) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

19 Item(s)

per page
  • LinkedIn