Tankyrase-1 (TANK1) antibody

Principal name

Tankyrase-1 (TANK1) antibody

Alternative names for Tankyrase-1 (TANK1) antibody

Tankyrase I, TNKS-1, TNKS1, TNKS, PARP5A, PARPL, TIN1, TINF1, TRF1-interacting ankyrin-related ADP-ribose polymerase

SwissProt ID

O95271 (Human)

Gene ID

8658 (TNKS)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Tankyrase-1 (TANK1) antibody

Tankyrase is a protein with homology to ankyrins as well as to the catalytic domain of poly (adenosine diphosphate ribose) polymerase (PARP). Tankyrase localizes to telomeres by binding to the telomeric repeat binding factor 1 (TRF1) through its ankyrin repeats. TRF1 is a negative regulator of telomere length maintenance. Tankyrase exhibits PARP activity functioning as acceptors for adenosine diphosphate (ADP) ribosylation. Since ADP ribosylation of TRF1 diminishes its ability to bind to telomeric DNA, this suggests that telomere function in human cells is regulated by poly (ADP) ribosylation. Both the cell cycle and TRF1 may regulate the subcellular localization of tankyrase. During interphase tankyrase colocalizes with TRF1 to telomeres plus nuclear pore complexes whereas during mitosis tankyrase localizes around the pericentriolar matrix of mitotic chromosomes.
Tankyrase may regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4 vesicles.

General readings

Seimiya H, Muramatsu Y, Ohishi T, Tsuruo T.
Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.
Cancer Cell. 2005 Jan;7(1):25-37.
PMID: 15652747.

10 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tankyrase-1 (TANK1) (N-term) antibody

  Goat Anti-Tankyrase / TANK1 Antibody  
HEK293 overexpressing TANK1 (lane 2) and TANK2 (lane 4) and probed with TA305803 (mock transfection in first lane). Lane three is empty. For full caption: see Application Notes. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tankyrase-1 (TANK1) antibody

  Rabbit Polyclonal Anti-TNKS Antibody  
WB Suggested Anti-TNKS Antibody Titration: 1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Tankyrase-1 (TANK1) antibody

  Rabbit Polyclonal Anti-TNKS Antibody  
WB Suggested Anti-TNKS Antibody Titration: 1 ug/ml; Positive Control: 721_B cell lysateTNKS is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Tankyrase-1 (TANK1) (N-term) antibody

TNKS Antibody (N-term) (AP54320PU-N) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the TNKS antibody detected the TNKS protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

TNKS - human gene knockout kit via CRISPR

TNKS - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TNKS - human gene knockout kit via CRISPR

TNKS - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TNKS - human gene knockout kit via CRISPR

TNKS - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TNKS - human gene knockout kit via CRISPR

TNKS - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TNKS (mGFP-tagged)-Human tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (TNKS), 200 uL, >10^7 TU/mL

Lenti ORF particles, TNKS (mGFP-tagged)-Human tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (TNKS), 200 uL, >10^7 TU/mL  
200 µl / €2,530.00
  OriGene Technologies, Inc.

Lenti ORF particles, TNKS (Myc-DDK-tagged)-Human tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (TNKS), 200 uL, >10^7 TU/mL

Lenti ORF particles, TNKS (Myc-DDK-tagged)-Human tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (TNKS), 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

10 Item(s)

per page
  • LinkedIn