TARDBP antibody

Principal name

TARDBP antibody

Alternative names for TARDBP antibody

TDP43, TDP-43, TAR DNA-binding protein 43

SwissProt ID

Q13148 (Human), Q5ZLN5 (Chick), Q921F2 (Mouse)

Gene ID

23435 (TARDBP), 230908 (Tardbp)

Available reactivities

Hu (Human), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Bov (Bovine), African clawed frog, Xen (Xenopus), Ze (Zebrafish), Prim (Primate), Por (Porcine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of TARDBP antibody

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription.HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

General readings

Buratti,E., (2005) J. Biol. Chem. 280 (45), 37572-37584

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TARDBP (1-261) antibody

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 2E2-D3 Purified Hu E, ICC/IF, P, RNAi, WB
50 µg / €420.00
  OriGene Technologies GmbH

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