TAT (Tyrosine aminotransferase) antibody

Principal name

TAT (Tyrosine aminotransferase) antibody

Alternative names for TAT (Tyrosine aminotransferase) antibody

L-tyrosine:2-oxoglutarate aminotransferase

SwissProt ID

P04694 (Rat), P17735 (Human), Q58CZ9 (Bovin), Q8QZR1 (Mouse)

Gene ID

6898 (TAT), 24813 (Tat), 234724

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Enzyme Immunoassay (E)

Background of TAT (Tyrosine aminotransferase) antibody

The transcriptiol transactivator (Tat) is a key regulatory protein of HIV. It is expressed early after the virus integrates into the cell, and stimulates the elongation of R polymerase II. It binds onto a sequence known as the TAR, or transactivator response element, located at the end of the HIV genetic chain. There, the tat protein helps assemble new copies of HIV. The tat protein-TAR complex speeds up the rate of viral reproduction by about a thousand times. If it is not present, the transcription process frequently stops short, and few functiol HIV particles are produced.Tat is an important potential target for antiretrovirals and vaccine development.Transcriptiol regulator that acts by binding to the trans-activating responsive sequence (TAR) R element and activates transcription initiation and/or elongation from the LTR promoter.

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