TBX21 / TBET antibody

Principal name

TBX21 / TBET antibody

Alternative names for TBX21 / TBET antibody

T-bet, TBLYM

SwissProt ID

Q9JKD8 (Mouse), Q9UL17 (Human)

Gene ID

30009 (TBX21), 57765 (Tbx21)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Marmoset, Mky (Monkey), Rb (Rabbit), GP (Guinea Pig), Sh (Sheep)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C)

Background of TBX21 / TBET antibody

T-bet, a T-box transcription factor, is expressed in CD4+ T-lymphocytes committed to T-helper (Th)1 T-cell development from naïve T-helper precursor cells (Thp) and redirects Th2 T cells to Th1 development. Anti-T-bet is a marker of mature T-cells and is expressed at very low levels in Thp cells and is absent in precursor T-lymphoblastic leukemia/lymphoma cells. Scattered small lymphocytes in the interfollicular T-cell zone of reactive lymphoid tissue, including tonsil, lymph node, and spleen exhibited nuclear staining for T-bet, with no T-bet staining observed in germinal centers or mantle or marginal zones.
T-bet is expressed in a significant subset of B-cell lymphoproliferative disorders, particularly at an early stage of B-cell development (precursor B-cell lymphoblastic leukemia/lymphoblastic lymphoma), and B-cell neoplasms derived from mature B cells, including CLL/SLL, marginal zone lymphoma, and hairy cell leukemia. In contrast, B-cell neoplasms derived from pregerminal center or germinal center B-cells, including mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphoma are negative for T-bet. Therefore, anti-T-bet should serve as a useful marker for the diagnosis and subtyping of B-cell and T-cell lymphoproliferative disorders.

General readings

Johrens,K., et al., (2006) Histopathology 48 (4), 343-352

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TBX21 / TBET antibody

CD4+ T cells were sorted from mouse splenocytes, then activated with Anti-Mouse CD3 and Anti-Mouse CD28, followed by culture in Th1-polarizing conditions, and re-stimulation with PMA and Ionomycin. Lysates from control (left) or PMA and Ionomycin-re-stimulated (right) cells were probed with Anti-T-bet Purified at 2 ug/ml, and revealed with Anti-Mouse IgG HRP. Mouse eBio39D (39D, 3-9D) Purified Hu, Ms, Rt IP, WB
25 µg / €120.00
  OriGene Technologies, Inc.

TBX21 / TBET antibody

CD4+ T cells were sorted from mouse spleen, activated with Anti-Mouse CD3 and Anti-Mouse CD28, followed by culture in Th1-polarizing conditions, and re-activation with PMA and Ionomycin. Lysates from control (left) or PMA and Ionomycin-re-activated (right) cells were probed with Anti-Human/Mouse T-bet Purified at 2 ug/mL, and revealed with Anti-Mouse IgG HRP. Mouse eBio4B10 (4B10, 4-B10) Purified Hu, Ms IP, P, WB
25 µg / €120.00
  OriGene Technologies, Inc.

TBX21 / TBET antibody

TBX21 Antibody (N-term) (Cat. #TA324549) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TBX21 antibody detected the TBX21 protein (arrow). Rabbit IgG Purified Hu ICC/IF, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

TBX21 / TBET antibody

Western blot analysis of TBX21 in 293 cell lysate with TBX21 antibody at  1 ug/ml. Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TBX21 / TBET antibody

Immunohistochemistry staining of Paraffin Tonsil tissue by T-bet antibody (dilution: 1:100 - 1:500; visualization of staining: Nuclear) Rabbit IgG1 MRQ-46 Purified Hu P
1 ml / €830.00
  OriGene Technologies, Inc.

TBX21 / TBET antibody

WB Suggested Anti-TBX21 Antibody Titration: 2.5ug/ml; ELISA Titer: 1:62500; Positive Control: Human Thymus Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TBX21 / TBET antibody

WB Suggested Anti-TBX21 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

TBX21 / TBET antibody

WB Suggested Anti-Tbx21 Antibody Titration: 0.2-1 ug/ml; Positive Control: NIH/3T3 cell lysate Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TBX21 / TBET antibody

WB Suggested Anti-TBX21 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1:312500; Positive Control: SP2/0 cell lysate Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt, Sh WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TBX21 / TBET antibody

TBX21 / TBET Rabbit IgG1 MRQ-46 Supernatant Hu C, P
1 ml / €910.00
  Acris Antibodies GmbH

TBX21 / TBET antibody

Western Blot analysis of TBX21 expression in transfected 293T cell line (H00030009-T02) by TBX21 MaxPab polyclonal antibody.

Lane 1: TBX21 transfected lysate(58.30 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

TBX21 / TBET antibody

TBX21 / TBET Mouse IgG2a 4F8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TBX21 / TBET antibody

TBX21 / TBET Mouse IgG2a 4C11 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

TBX21 / TBET antibody

TBX21 / TBET Mouse IgG2a 1F4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TBX21 / TBET antibody

TBX21 monoclonal antibody (M07), clone 3D7. Western Blot analysis of TBX21 expression in NIH/3T3 ( Cat # L018V1 ). Mouse IgG2a 3D7 Purified Hu, Ms E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TBX21 / TBET antibody

Western Blot analysis of TBX21 expression in transfected 293T cell line by TBX21 monoclonal antibody (M09), clone 1D12.

Lane 1: TBX21 transfected lysate(58.3 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 1D12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TBX21 / TBET antibody

TBX21 monoclonal antibody (M10), clone 2F10. Western Blot analysis of TBX21 expression in human spleen. Mouse IgG2a 2F10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TBX21 / TBET antibody

Human Thymus; WB Suggested Anti-TBX21 Antibody Titration: 2.5ug/ml. ELISA Titer: 1:62500. Positive Control: Human Thymus; TBX21 antibody - N-terminal region (ARP31924_T100) in Human Thymus cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms WB
0.1 mg / €310.00
  AVIVA Systems Biology

TBX21 / TBET antibody

Human kidney; TBX21 antibody - middle region (ARP32612_P050) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

TBX21 / TBET (N-term) antibody

Mouse NIH-3T3; WB Suggested Anti-Tbx21 Antibody Titration: 0.2-1 ug/ml. Positive Control: NIH/3T3 cell lysate; Tbx21 antibody - N-terminal region (ARP37250_P050) in Mouse NIH-3T3 cells using Western Blot Rabbit Aff - Purified Ms WB
50 µg / €350.00
  AVIVA Systems Biology

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