TCL1A / TCL1 antibody

Principal name

TCL1A / TCL1 antibody

Alternative names for TCL1A / TCL1 antibody

TCL-1, T-cell leukemia/lymphoma protein 1A

SwissProt ID

P56279 (Human), P56280 (Mouse)

Gene ID

8115 (TCL1A), 21432 (Tcl1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Frozen Sections (C), Immunoprecipitation (IP)

Background of TCL1A / TCL1 antibody

TCL1 (T cell leukemia/lymphoma 1), MTCP1 (mature T cell proliferation 1) and TCL1b belong to the TCL1 proto-oncogene family. The TCL1 gene at chromosome 14q32.1 is co mmonly activated in T cell neoplasms by chromosome r earrangements such as inversions inv(14)(q11;q32) and translocations t(14;14)(q11;q32) or t(7;14)(q35;q32). TCL1 expression is limited to immature thymocytes in early T-cell progenitors and from pre-B to mature B cells in the B-cell lineage. The TCL1/MTCP1/TCL1b proto-oncogene activation is the hallmark of human T-cell prolymphocytic leukemia (T-PLL), a form of adult leukemia. In addition to T-PLL, TCL1 is overexpressed in Burkitt's lymphoma cell lines, the majority of AIDS-related non-Hodgkin’s lymphoma-designated immunoblastic lymphoma plasmacytoids, lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and primary cutaneous B-cell lymphoma. It is also implicated in the development of hematopoietic abnormalities in patients with ataxia-telangiectasia. The members of the TCL1 proto-oncogene family bind to the serine/threonine kinase Akt (PKB), increasing its phosphorylation status and kinase activity. Akt is a crucial regulator in transduction of antiapoptotic and proliferative signals in T cells. TCL1 facilitates heterodimerization of different Akt molecules, which may contribute to the development of human malignancies associated w ith TCL1 overexpression.

General readings

Clone 27D6/20 is used in these references.
1. Boccellato, F., et al., J. Virol. 81, 2274-2282 (2002)
2. Vermi, W., et al., Blood 107, 454-462 (2006)
3. Zanesi, N., et al., Cancer Res. 66, 915-920 (2006)
4. Künstle, G., et al., Mol. Cell. Biol. 22, 1513-1525 (2002)
5. Laine, J., et al., J. Biol. Chem. 277, 3743-3751 6.
6. Bichi, R., et al., PNAS 99, 6955-6960 (2002)
7. Narducci, M. G., et al., Cancer Res. 60, 2095-2100 (2000)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TCL1A / TCL1 antibody

TCL1A / TCL1 Mouse IgG MRQ-7 Supernatant Hu C, P
1 ml / €810.00
  Acris Antibodies GmbH

TCL1A / TCL1 antibody

  Goat Polyclonal Antibody against TCL1A  
TA303214 (0.1µg/ml) staining of Jurkat Cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TCL1A / TCL1 antibody

  Mouse Anti-Human TCL1 Purified (25 ug)  
Staining of Daudi cells with 0.25 ug of Mouse IgG2b kappa Isotype Control Purified (open histogram) or 0.25 ug of Anti-Human TCL1 Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE .  Total viable cells were used for analysis. Mouse eBio1-21 (1-21) Purified Hu F, IP, P, WB
25 µg / €120.00
  OriGene Technologies, Inc.

TCL1A / TCL1 antibody

  Anti-TCL1A Rabbit Polyclonal Antibody  
Predicted band size: 13 kDa . Positive control: Ramos cell lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TCL1A / TCL1 antibody

  TCL1A Rabbit Polyclonal Antibody  
Western blot analysis of extracts from HUVEC cells, treated with UV (15mins), using Chk1 (Phospho-Ser296) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

TCL1A / TCL1 antibody

  Mouse Monoclonal TCL1 Antibody  
Immunohistochemistry staining of Paraffin Tonsil, B-cell lymphoma tissue by TCL1 antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic, nuclear) Mouse IgG MRQ-7 Purified Hu P
1 ml / €680.00
  OriGene Technologies, Inc.

TCL1A / TCL1 antibody

  Rabbit Polyclonal Anti-TCL1A Antibody - N-terminal region  
WB Suggested Anti-TCL1A Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human brain Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

TCL1A / TCL1 antibody

  Rabbit Monoclonal anti-TCL1A Antibody  
TCL1A / TCL1 Rabbit SP248 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

TCL1A - human gene knockout kit via CRISPR

TCL1A - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TCL1A - human gene knockout kit via CRISPR

TCL1A - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TCL1A - human gene knockout kit via CRISPR

TCL1A - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TCL1A - human gene knockout kit via CRISPR

TCL1A - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tcl1 - mouse gene knockout kit via CRISPR

Tcl1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Tcl1 - mouse gene knockout kit via CRISPR

Tcl1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tcl1 - mouse gene knockout kit via CRISPR

Tcl1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tcl1 - mouse gene knockout kit via CRISPR

Tcl1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TCL1A / TCL1 (transcript variant 1)

  Recombinant protein of human T-cell leukemia/lymphoma 1A (TCL1A), transcript variant 1  
TCL1A / TCL1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

TCL1A / TCL1 (transcript variant 2)

  Recombinant protein of human T-cell leukemia/lymphoma 1A (TCL1A), transcript variant 2  
TCL1A / TCL1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

TCL1A / TCL1 (1-114)

TCL1A / TCL1 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

TCL1A / TCL1 (1-114)

TCL1A / TCL1 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

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