TCL1A / TCL1 antibody

Principal name

TCL1A / TCL1 antibody

Alternative names for TCL1A / TCL1 antibody

TCL-1, T-cell leukemia/lymphoma protein 1A

SwissProt ID

P56279 (Human), P56280 (Mouse)

Gene ID

8115 (TCL1A), 21432 (Tcl1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Immunoprecipitation (IP), Frozen Sections (C)

Background of TCL1A / TCL1 antibody

TCL1 (T cell leukemia/lymphoma 1), MTCP1 (mature T cell proliferation 1) and TCL1b belong to the TCL1 proto-oncogene family. The TCL1 gene at chromosome 14q32.1 is co mmonly activated in T cell neoplasms by chromosome r earrangements such as inversions inv(14)(q11;q32) and translocations t(14;14)(q11;q32) or t(7;14)(q35;q32). TCL1 expression is limited to immature thymocytes in early T-cell progenitors and from pre-B to mature B cells in the B-cell lineage. The TCL1/MTCP1/TCL1b proto-oncogene activation is the hallmark of human T-cell prolymphocytic leukemia (T-PLL), a form of adult leukemia. In addition to T-PLL, TCL1 is overexpressed in Burkitt's lymphoma cell lines, the majority of AIDS-related non-Hodgkin’s lymphoma-designated immunoblastic lymphoma plasmacytoids, lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and primary cutaneous B-cell lymphoma. It is also implicated in the development of hematopoietic abnormalities in patients with ataxia-telangiectasia. The members of the TCL1 proto-oncogene family bind to the serine/threonine kinase Akt (PKB), increasing its phosphorylation status and kinase activity. Akt is a crucial regulator in transduction of antiapoptotic and proliferative signals in T cells. TCL1 facilitates heterodimerization of different Akt molecules, which may contribute to the development of human malignancies associated w ith TCL1 overexpression.

General readings

Clone 27D6/20 is used in these references.
1. Boccellato, F., et al., J. Virol. 81, 2274-2282 (2002)
2. Vermi, W., et al., Blood 107, 454-462 (2006)
3. Zanesi, N., et al., Cancer Res. 66, 915-920 (2006)
4. Künstle, G., et al., Mol. Cell. Biol. 22, 1513-1525 (2002)
5. Laine, J., et al., J. Biol. Chem. 277, 3743-3751 6.
6. Bichi, R., et al., PNAS 99, 6955-6960 (2002)
7. Narducci, M. G., et al., Cancer Res. 60, 2095-2100 (2000)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TCL1A / TCL1 antibody

TCL1A / TCL1 Mouse IgG MRQ-7 Supernatant Hu C, P
1 ml / €730.00
  Acris Antibodies GmbH

TCL1A / TCL1 antibody

TA303214 (0.1µg/ml) staining of Jurkat Cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TCL1A / TCL1 antibody

Staining of Daudi cells with 0.25 ug of Mouse IgG2b kappa Isotype Control Purified (open histogram) or 0.25 ug of Anti-Human TCL1 Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE .  Total viable cells were used for analysis. Mouse eBio1-21 (1-21) Purified Hu F, IP, P, WB
25 µg / €120.00
  OriGene Technologies, Inc.

TCL1A / TCL1 antibody

Predicted band size: 13 kDa . Positive control: Ramos cell lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TCL1A / TCL1 antibody

Western blot analysis of Ramos cell lysate using TCL1A antibody. Rabbit IgG Purified Hu, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

TCL1A / TCL1 antibody

Immunohistochemistry staining of Paraffin Tonsil, B-cell lymphoma tissue by TCL1 antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic, nuclear) Mouse IgG MRQ-7 Purified Hu P
1 ml / €290.00
  OriGene Technologies, Inc.

TCL1A / TCL1 antibody

WB Suggested Anti-TCL1A Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human brain Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

TCL1A / TCL1 antibody

Figure 1. Immunohistochemical detection of TCL1 on paraffin embedded section of Human tonsil with TCL1 antibody (AM20006AF-N). Mouse IgG1 27D6/20 Azide Free F, P, WB
0.1 mg / €410.00
  Acris Antibodies GmbH

TCL1A / TCL1 antibody

Flow cytometric analysis of TCL1 expression on Raji. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26558BT-N to the cells. Mouse IgG1 27D6/21 Biotin Hu F
0.1 ml / €460.00
  Acris Antibodies GmbH

TCL1A / TCL1 antibody

Human tonsil stained with anti-TCL1A antibody Cat.-No AM33390PU-N (Clone SP248). Rabbit IgG SP248 Purified Hu F, P, WB
0.5 ml / €560.00
  Acris Antibodies GmbH

TCL1A / TCL1 antibody

Human tonsil stained with anti-TCL1A antibody Cat.-No AM33390PU-N (Clone SP248). Rabbit IgG SP248 Purified Hu F, P, WB
1 ml / €820.00
  Acris Antibodies GmbH

TCL1A / TCL1 antibody

Human tonsil stained with anti-TCL1A antibody Cat.-No AM33390PU-N (Clone SP248). Rabbit IgG SP248 Purified Hu F, P, WB
0.1 ml / €350.00
  Acris Antibodies GmbH

TCL1A / TCL1 antibody

Immunofluorescence of purified MaxPab antibody to TCL1A on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

TCL1A / TCL1 antibody

Detection limit for recombinant GST tagged TCL1A is approximately 0.1ng/ml as a capture antibody. Mouse IgG1 1E8 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

TCL1A / TCL1 antibody

Detection limit for recombinant GST tagged TCL1A is approximately 1ng/ml as a capture antibody. Mouse IgG2a 3G5 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

TCL1A / TCL1 antibody

TCL1A / TCL1 Mouse IgG2a 3G5 Ascites Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

TCL1A / TCL1 antibody

Detection limit for recombinant GST tagged TCL1A is approximately 1ng/ml as a capture antibody. Mouse IgG2a 2F1 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

TCL1A / TCL1 antibody

Detection limit for recombinant GST tagged TCL1A is approximately 0.3ng/ml as a capture antibody. Mouse IgG2b 1C4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TCL1A / TCL1 antibody

Western Blot analysis of TCL1A expression in transfected 293T cell line by TCL1A monoclonal antibody (M07), clone 3G10.

Lane 1: TCL1A transfected lysate(13.5 KDa).
Lane 2: Non-transfected lysate. Mouse IgG1 3G10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TCL1A / TCL1 antibody

Detection limit for recombinant GST tagged TCL1A is approximately 0.03ng/ml as a capture antibody. Mouse IgG2a 3H6 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

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