TDGF1 / CRIPTO antibody

Principal name

TDGF1 / CRIPTO antibody

Alternative names for TDGF1 / CRIPTO antibody

Cripto-1 growth factor, CRGF, Teratocarcinoma-derived growth factor 1, Epidermal growth factor-like cripto protein CR1

SwissProt ID

P13385 (Human), P51865 (Mouse)

Gene ID

6997 (TDGF1)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Rt (Rat), Prim (Primate)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of TDGF1 / CRIPTO antibody

Cripto-1 (teratocarcinoma-derived growth factor-1) is the origil member of EGF-cripto-1-FRL-1-cryptic (CFC) family of vertebrate sigling molecules which is essential for embryonic development and it implicates in carcinogenesis also. Cripto1 functions as a co-receptor for NODAL (TGF-beta member) and is essential for mesoderm as well as endoderm formation and anterior-posterior and left-right axis establishment. After executing key functions during embryonic development, it dramatically disappears in adult tissues (except stem cells). Cripto-1 modulate sigling of TGF-beta family members (NODAL, GDF-1/-3, Activin, TGF-beta1 etc), and activate c-src/MAPK/AKT pathway in a Glypican-1/GRP78-dependent manner, and cross-talks with erbB4, Wnt/beta-catenin, NOTCH, Caveolin-1, and Apelin/putative receptor protein related to angiotensin-type I receptor pathways. During embryonic development, Cripto-1 together with Nodal controls cell migration and EMT, whereas, posttally, it regulates the branching morphogenesis of mammary gland. Moreover, in adult life it gets re -expressed in several type of tumors wherein it promotes cell proliferation, migration, invasion, EMT, and angiogenesis.

General readings

1. Parisi S, D\1Andrea D, Lago CT, Adamson ED, Persico MG, Minchiotti G Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells. J Cell Biol. 2003 Oct 27;163(2):303-14
PMID: 14581455

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TDGF1 / CRIPTO antibody

  Rabbit Polyclonal Antibody against Cripto - Embryonic Stem Cell Marker  
Western Blot: Cripto1 Antibody - Analysis of Cripto in MDA-MB231 lysates. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TDGF1 / CRIPTO antibody

  Rabbit polyclonal Cripto-1 TDGF1 antibody  
WB using Anti-Cripto-1 shows detection of endogenous and transfected Cripto-1 from mouse or human. Endogenous detection using mouse P19 embryonal carcinoma cells and human NCCIT testicular embryonal carcinoma cells. EpH4 CR-1 is a mouse mammary epithelial cell line stably expressing Cripto-1. NTERA cells are human embryonal carcinoma cells that, when overgrown, differentiate and lose Cripto-1 expression. COS7 cells transfected with human Cripto-1 expression vector were used as a positive control and EpH4 WT cells were used as a negative control. Dilution: 1:500 . Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

TDGF1 / CRIPTO antibody

  Rabbit Polyclonal TDGF1 Antibody  
Western blot analysis of TDGF1 in 293 cell lysate with TDGF1 antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TDGF1 / CRIPTO antibody

  Rabbit Polyclonal CRIPTO Antibody  
Western Blot: Cripto1 Antibody [TA336263] - Analysis of Cripto in Dicer knockout mouse embryonic stem cell lysate. Rabbit Purified Hu, Ms F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TDGF1 / CRIPTO antibody

  Rabbit Polyclonal Anti-TDGF1 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (TDGF1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TDGF1 / CRIPTO antibody

  Rabbit Polyclonal anti-Cripto-1 Antibody  
Human Colon Carcinoma stained with anti-Cripto-1 antibody. Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TDGF1 / CRIPTO antibody

  Rabbit Polyclonal Cripto1 Antibody  
ELISA: Cripto1 Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

TDGF1 / CRIPTO antibody

Western blot analysis using TDGF1 mAb against HEK293 (1) and TDGF1(AA: 31-188)-hIgGFc transfected HEK293 (2) cell lysate. Mouse IgG1 3A6 Ascites Hu E, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

TDGF1 / CRIPTO (N-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TDGF1 / CRIPTO antibody

Immunohistochemistry: AP20147PU-N CRIPTO Antibody staining of Paraffin Embedded Human Placenta at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P
0.1 mg / €350.00
  Acris Antibodies GmbH

TDGF1 / CRIPTO antibody

Immunocytochemistry/Immunofluorescence: Cripto1 antibody was tested in HeLa cells with Dylight 488 (green). Nuclei were counterstained with DAPI (blue) and tubulin was stained with alpha tubulin (red). Rabbit IgG Aff - Purified Bov, Can, Hu, Ms, Prim, Rt F, ICC/IF, WB
0.1 ml / €380.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

TDGF1 - human gene knockout kit via CRISPR

TDGF1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TDGF1 - human gene knockout kit via CRISPR

TDGF1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TDGF1 - human gene knockout kit via CRISPR

TDGF1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TDGF1 - human gene knockout kit via CRISPR

TDGF1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

TDGF1 overexpression lysate

TDGF1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TDGF1 (mGFP-tagged) - Human teratocarcinoma-derived growth factor 1 (TDGF1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, TDGF1 (mGFP-tagged) - Human teratocarcinoma-derived growth factor 1 (TDGF1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, TDGF1 (mGFP-tagged)-Human teratocarcinoma-derived growth factor 1 (TDGF1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, TDGF1 (mGFP-tagged)-Human teratocarcinoma-derived growth factor 1 (TDGF1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, TDGF1 (Myc-DDK tagged) - Human teratocarcinoma-derived growth factor 1 (TDGF1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, TDGF1 (Myc-DDK tagged) - Human teratocarcinoma-derived growth factor 1 (TDGF1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Lenti ORF particles, TDGF1 (Myc-DDK-tagged)-Human teratocarcinoma-derived growth factor 1 (TDGF1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, TDGF1 (Myc-DDK-tagged)-Human teratocarcinoma-derived growth factor 1 (TDGF1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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