TDGF1 / CRIPTO antibody

Principal name

TDGF1 / CRIPTO antibody

Alternative names for TDGF1 / CRIPTO antibody

Cripto-1 growth factor, CRGF, Teratocarcinoma-derived growth factor 1, Epidermal growth factor-like cripto protein CR1

SwissProt ID

P13385 (Human), P51865 (Mouse)

Gene ID

6997 (TDGF1)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Rt (Rat), Prim (Primate)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of TDGF1 / CRIPTO antibody

Cripto-1 (teratocarcinoma-derived growth factor-1) is the origil member of EGF-cripto-1-FRL-1-cryptic (CFC) family of vertebrate sigling molecules which is essential for embryonic development and it implicates in carcinogenesis also. Cripto1 functions as a co-receptor for NODAL (TGF-beta member) and is essential for mesoderm as well as endoderm formation and anterior-posterior and left-right axis establishment. After executing key functions during embryonic development, it dramatically disappears in adult tissues (except stem cells). Cripto-1 modulate sigling of TGF-beta family members (NODAL, GDF-1/-3, Activin, TGF-beta1 etc), and activate c-src/MAPK/AKT pathway in a Glypican-1/GRP78-dependent manner, and cross-talks with erbB4, Wnt/beta-catenin, NOTCH, Caveolin-1, and Apelin/putative receptor protein related to angiotensin-type I receptor pathways. During embryonic development, Cripto-1 together with Nodal controls cell migration and EMT, whereas, posttally, it regulates the branching morphogenesis of mammary gland. Moreover, in adult life it gets re -expressed in several type of tumors wherein it promotes cell proliferation, migration, invasion, EMT, and angiogenesis.

General readings

1. Parisi S, D\1Andrea D, Lago CT, Adamson ED, Persico MG, Minchiotti G Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells. J Cell Biol. 2003 Oct 27;163(2):303-14
PMID: 14581455

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TDGF1 / CRIPTO antibody

IHC Image for Cat#AP15504PU-S / AP15504PU-N Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

TDGF1 / CRIPTO antibody

IHC Image for Cat#AP15504PU-S / AP15504PU-N Rabbit Purified Hu P
1 ml / €450.00
  Acris Antibodies GmbH

TDGF1 / CRIPTO antibody

IHC Image for Cat#AP15504PU-S / AP15504PU-N Rabbit Purified Hu P
0.1 ml / €180.00
  Acris Antibodies GmbH

TDGF1 / CRIPTO antibody

Western Blot: Cripto1 Antibody - Analysis of Cripto in MDA-MB231 lysates. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TDGF1 / CRIPTO antibody

WB using Anti-Cripto-1 shows detection of endogenous and transfected Cripto-1 from mouse or human. Endogenous detection using mouse P19 embryonal carcinoma cells and human NCCIT testicular embryonal carcinoma cells. EpH4 CR-1 is a mouse mammary epithelial cell line stably expressing Cripto-1. NTERA cells are human embryonal carcinoma cells that, when overgrown, differentiate and lose Cripto-1 expression. COS7 cells transfected with human Cripto-1 expression vector were used as a positive control and EpH4 WT cells were used as a negative control. Dilution: 1:500 . Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TDGF1 / CRIPTO antibody

Western blot analysis of TDGF1 in 293 cell lysate with TDGF1 antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TDGF1 / CRIPTO antibody

Western Blot: Cripto1 Antibody [TA336263] - Analysis of Cripto in Dicer knockout mouse embryonic stem cell lysate. Rabbit Purified Hu, Ms F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TDGF1 / CRIPTO antibody

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (TDGF1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TDGF1 / CRIPTO antibody

Human Colon Carcinoma stained with anti-Cripto-1 antibody. Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TDGF1 / CRIPTO antibody

ELISA: Cripto1 Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

TDGF1 / CRIPTO antibody

Western blot analysis using TDGF1 mAb against HEK293 (1) and TDGF1(AA: 31-188)-hIgGFc transfected HEK293 (2) cell lysate. Mouse IgG1 3A6 Ascites Hu E, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

TDGF1 / CRIPTO antibody

WB using Anti-Cripto-1 shows detection of endogenous and transfected Cripto-1 from mouse or human. Endogenous detection using mouse P19 embryonal carcinoma cells and human NCCIT testicular embryonal carcinoma cells. EpH4 CR-1 is a mouse mammary epithelial cell line stably expressing Cripto-1. NTERA cells are human embryonal carcinoma cells that, when overgrown, differentiate and lose Cripto-1 expression. COS7 cells transfected with human Cripto-1 expression vector were used as a positive control and EpH4 WT cells were used as a negative control. Dilution: 1:500 . Rabbit IgG Aff - Purified Hu, Ms E, WB
25 µl / €190.00
  Acris Antibodies GmbH

TDGF1 / CRIPTO (N-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TDGF1 / CRIPTO antibody

Immunohistochemistry: AP20147PU-N CRIPTO Antibody staining of Paraffin Embedded Human Placenta at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P
0.1 mg / €350.00
  Acris Antibodies GmbH

TDGF1 / CRIPTO antibody

TDGF1 / CRIPTO Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

TDGF1 / CRIPTO antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with TDGF1 polyclonal antibody ( Cat # PAB3871 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

TDGF1 / CRIPTO antibody

Western blot using TDGF1 polyclonal antibody ( Cat # PAB9995 ) shows detection of endogenous and transfected TDGF1 from mouse and human sources.
The TDGF1 band appears above the 17.8 kDa marker.
Endogenous detection is shown using mouse P19 embryonal carcinoma cells and human NCCIT testicular embryonal carcinoma cells.
EpH4 CR-1 is a mouse mammary epithelial cell line stably expressing mouse TDGF1.
NTERA cells are human embryonal carcinoma cells that, when overgrown, differentiate and lose TDGF1 expression.
COS-7 cells transfected with human TDGF1 expression vector were used as a positive control and EpH4 WT cells were used as a negative control.
A non-specific band at 45 kDa may be present in some preparations.
The primary antibody was used at a 1 : 500 dilution.
Personal communication, C. Bianco, NCI, Bethesda, MD. Hu, Ms
0.1 mg / €560.00
  Abnova Taiwan Corp.

TDGF1 / CRIPTO antibody

Western blot analysis of Tdgf1 in 20 µg of MDA-MB-21 lysate with Tdgf1 polyclonal antibody ( Cat# PAB12003 ). Rabbit Hu WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

TDGF1 / CRIPTO antibody

Western blot analysis of TDGF1 in 20 µg of MDA-MB-21 lysate with TDGF1 polyclonal antibody ( Cat# PAB12004 ). Rabbit Hu WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

TDGF1 / CRIPTO (Center) antibody

Human Jurkat; WB Suggested Anti-TDGF1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Jurkat cell lysate; TDGF1 antibody - middle region (ARP45440_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

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