TDRD7 antibody

Principal name

TDRD7 antibody

Alternative names for TDRD7 antibody

Tudor domain-containing protein 7, PCTAIRE2BP, Trap, Tudor repeat associator with PCTAIRE 2, PCTAIRE2-binding protein

SwissProt ID

Q8K1H1 (Mouse), Q8NHU6 (Human), Q9R1R4 (Rat)

Gene ID

23424 (TDRD7)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of TDRD7 antibody

Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to symmetrically dimethylated arginines of arginine-glycine (RG) rich sequences found in the C-terminal tails of Sm proteins. The SMN protein is linked to spinal muscular atrophy. Another example is the tandem tudor domains of 53BP1, which bind to histone H4 specifically dimethylated at Lys20 (H4-K20me2). 53BP1 is a key transducer of the DNA damage checkpoint signal. There are 7 tudor domain containing proteins (TDRD1-TDRD9) each forming hetero-complexes for epigenetic regulations in gene expression. TDRD proteins, specially TDRD1, 6, 7 and 9 consist a conserved components of chromatoid bodies in mice (1). TRD1 and TRD9 bind to arginine dimethylated MILI, and MIWI2 proteins, both are mouse piwi proteins. These two TDRD proteins regulate the piwi-interacting RNA (piRNA) pathways to establish retrotransposon silencing in fetal prospermatogonia (2). The TDRD1 and MILI are localized in intermitochondrial cement (pi bodies), while TDRD9 and MIWI2 are concentrated in prospermatogonia (3). The Tdrd gene family constitutes an essential class of spermatogenesis genes with each member having a distinct function at different differentiation stages. Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis in concert with TDRD6. The deficiency of TDRD7 causes male sterility and age-related cataract as well as glaucoma (4). The TDRD7 is expressed in lens fiber cells and localize to RNP aggregate named as TDRD granules. What role other TSRD members play in physiological functions is still unknown. TheTDRD7-selective antibodies were generated against unique antigenic sequence form with in the C-terminal 50 amino acids. The sequence was conserved in rat, mouse TDRD7 but was unique only to TDRD7 and was not present in other Tudor proteins. The TDRD7 antibodies were affinity purified over immobilized antigen based chromatography, and the affinity purified immunoglobulins are stabilized in antibody stabilization buffer.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TDRD7 (C-term) antibody

TDRD7 antibody (C-term) (AP54212PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TDRD7 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH


Catalog No.    

TDRD7 overexpression lysate

TDRD7 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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