Tenascin / TNC / HXB antibody

Principal name

Tenascin / TNC / HXB antibody

Alternative names for Tenascin / TNC / HXB antibody

Tenascin-C, TN-C, Hexabrachion, Cytotactin, Neuronectin, GMEM, Myotendinous antigen, Glioma-associated-extracellular matrix antigen, GP 150-225

SwissProt ID

P10039 (Chick), P24821 (Human), Q29116 (Pig), Q80YX1 (Mouse)

Gene ID

3371 (TNC), 21923 (Tnc), 7148 (TNXB)

Available reactivities

Hu (Human), Ms (Mouse), Chk (Chicken), Rt (Rat), GP (Guinea Pig), Rb (Rabbit), Por (Porcine), Mky (Monkey)

Available hosts

Rabbit, Mouse, Chicken, Rat, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Dot blot (Dot), Radioimmunoassay (R)

Background of Tenascin / TNC / HXB antibody

Tenascins were first characterized in the early 1980’s. Since then hundreds of publications on tenascin in normal tissues, pathologically reactive tissues and carcinomas have been published. However, only recently more elective studies have been done. In these studies retrospective material from pathology files has been studied as well as larger fresh material collected during several years from patients. These studies have now attempted to reveal more specific points in carcinogenesis and pathological tissue reactions. 
It has been demonstrated that tenascin immunoreactivity in breast carcinoma cells could be indicative of metastasis and survival. Recent studies using retrospective material showed that the expression of tenascin in invasion border of early breast cancer significantly correlates with higher risk of distant metastasis. These studies have been continued now and the preliminary results clearly suggest that expression of tenascin in invasion border of early breast cancer is significantly associated with proliferative activity and higher risk of local recurrence. This result implicates a wide application for tenascin antibodies in the breast pathology.

The point is that tenascin expression may suggest situations in which even small breast carcinomas may need more intensive complementary therapy (chemotherapy etc.). Recent studies have also shown that tenascin is significantly increased in airway basement membrane of asthmatics and rapidly decreases by inhaled steroid. This result suggests that tenascin expression may be used to monitor the disease status and outcome of treatment in different types of asthma.

General readings

This product has been used in:Wirl G et al. Mammary epithelial cell differentiation in vitro is regulated by an interplay of EGF action and tenascin-C downregulation. J Cell Sci 108 (Pt 6):2445-56 (1995). PubMed PMID: 7545689
Weller A et al. Amino acid sequence of mouse tenascin and differential expression of two tenascin isoforms during embryogenesis. J Cell Biol 112:355-62 (1991). PubMed PMID: 1703162
Aufderheide E & Ekblom P Tenascin during gut development: appearance in the mesenchyme, shift in molecular forms, and dependence on epithelial-mesenchymal interactions. J Cell Biol 107:2341-9 (1988). PubMed PMID: 2461951
General / background references:Maschler S et al. Enhanced tenascin-C expression and matrix deposition during Ras/TGF-beta-induced progression of mammary tumor cells. Oncogene 23:3622-33 (2004). PubMed PMID: 15116096
Erickson HP & Bourdon MA Tenascin: an extracellular matrix protein prominent in specialized embryonic tissues and tumors. Annu Rev Cell Biol 5:71-92 (1989). PubMed PMID: 2480799
Bourdon MA & Ruoslahti E Tenascin mediates cell attachment through an RGD-dependent receptor. J Cell Biol 108:1149-55 (1989). PubMed PMID: 2466038
1. Weller A et al. Amino acid sequence of mouse tenascin and differential expression of two tenascin isoforms during embryogenesis. J Cell Biol 112:355-62 (1991). PubMed: 1703162
2. Aufderheide E & Ekblom P Tenascin during gut development: appearance in the mesenchyme, shift in molecular forms, and dependence on epithelial-mesenchymal interactions. J Cell Biol 107:2341-9 (1988). PubMed: 2461951

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tenascin / TNC / HXB antibody

Immunohistochemistry staining of tonsil (paraffin-embedded sections) with anti-Human Tenascin antibody (T2H5) Cat.-No BM722S. Mouse IgG1 T2H5 Purified Hu E, IP, P, WB
0.1 mg / €230.00
  Acris Antibodies GmbH

Tenascin / TNC / HXB antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-TNC rabbit polyclonal antibody. (TA590705) Rabbit IgG Purified Hu, Mky, Ms E, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Tenascin / TNC / HXB antibody

Immunohistochemistry: Tenascin C Antibody (4C8MS) - Immunohistochemical analysis of Tenascin C on mouse bone and tendon using anti-Tenascin C. Mouse IgG1 4C8MS Purified Hu, Ms, Rt C, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tenascin / TNC / HXB antibody

Predicted cell location: Secreted,Extracellular matrix. Positive control: Human esophagus cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human esophagus cancer tissue using TNC antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Tenascin / TNC / HXB antibody

ELISA: Tenascin C Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

Tenascin / TNC / HXB antibody

ELISA: Tenascin C Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

Tenascin / TNC / HXB antibody

ELISA: Tenascin C Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

Tenascin / TNC / HXB antibody

ELISA: Tenascin C Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

Tenascin / TNC / HXB antibody

ELISA: Tenascin C Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

Tenascin / TNC / HXB antibody

Immunohistochemistry on paraffin Human mammary cancer sections Mouse IgG1 T20 Purified Hu C, ICC/IF, IP, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Tenascin / TNC / HXB antibody

Tenascin / TNC / HXB Mouse IgG2a DB7 Ig Fraction Hu C, ICC/IF, IP, P, WB
0.1 mg / €470.00
  Acris Antibodies GmbH

Tenascin / TNC / HXB antibody

Tenascin / TNC / HXB Mouse IgG1 EB2 Ig Fraction GP, Hu, Rb C, E, WB
0.1 mg / €470.00
  Acris Antibodies GmbH

Tenascin / TNC / HXB antibody

TNC polyclonal antibody (A01), Lot # 051011JC01 Western Blot analysis of TNC expression in SJCRH30 ( Cat # L027V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Tenascin / TNC / HXB antibody

Tenascin / TNC / HXB Mouse IgG1 3B4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Tenascin / TNC / HXB antibody

Tenascin / TNC / HXB Mouse IgG1 T2H5 Hu C, IP, P, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Tenascin / TNC / HXB antibody

Tenascin / TNC / HXB Mouse IgG2a DB7 Hu C, ICC/IF, P, WB
0.1 mg / €640.00
  Abnova Taiwan Corp.

Tenascin / TNC / HXB antibody

Tenascin / TNC / HXB Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

Tenascin / TNC / HXB antibody

Western blot analysis of Tenascin C expression in U2OS (A); MCF7 (B); NIH3T3 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Por, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Tenascin / TNC / HXB antibody

Western blot analysis of Tenascin C expression in U2OS (A); MCF7 (B); NIH3T3 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Por, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Tenascin / TNC / HXB antibody

Western blot analysis of Tenascin C expression in U2OS (A); MCF7 (B); NIH3T3 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Por, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

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