Tetraspanin-12 (TSPAN12) antibody

Principal name

Tetraspanin-12 (TSPAN12) antibody

Alternative names for Tetraspanin-12 (TSPAN12) antibody

Tspan-12, Tetraspan NET-2, NET2, TM4SF12, Transmembrane 4 superfamily member 12

SwissProt ID

O95859 (Human), Q29RH7 (Bovin), Q569A2 (Rat), Q5ZIF5 (Chick), Q8BKT6 (Mouse)

Gene ID

23554 (TSPAN12)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Paraffin Sections (P)

Background of Tetraspanin-12 (TSPAN12) antibody

Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

General readings

Scherer,S.W., (2003) Science 300 (5620), 767-772

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Tetraspanin-12 (TSPAN12) antibody

WB Suggested Anti-TSPAN12 Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Tetraspanin-12 (TSPAN12) antibody

WB Suggested Anti-TSPAN12 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Thymus Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Tetraspanin-12 (TSPAN12) (C-term) antibody

Western blot analysis of TSPAN12 Antibody (C-term) (AP18230PU-N) in T47D cell line lysates (35ug/lane). TSPAN12 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Tetraspanin-12 (TSPAN12) antibody

Human HepG2; WB Suggested Anti-TSPAN12 Antibody Titration: 0.2-1 ug/ml. Positive Control: HepG2 cell lysate; TSPAN12 antibody - middle region (ARP46887_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

Tetraspanin-12 (TSPAN12) antibody

Human Thymus; WB Suggested Anti-TSPAN12 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human Thymus; TSPAN12 antibody - middle region (ARP46888_P050) in Human Thymus cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

Tetraspanin-12 (TSPAN12) antibody

Tetraspanin-12 (TSPAN12) Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €440.00
  Novus Biologicals Inc.

Tetraspanin-12 (TSPAN12) antibody

Tetraspanin-12 (TSPAN12) Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Tetraspanin-12 (TSPAN12)

Tetraspanin-12 (TSPAN12) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

8 Item(s)

per page
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