TFAM / TCF6 antibody

Principal name

TFAM / TCF6 antibody

Alternative names for TFAM / TCF6 antibody

TCF6L2, MtTF1, TCF-6, mitochondrial Transcription factor A, Mitochondrial transcription factor 1, Transcription factor 6-like 2, Transcription factor 6

SwissProt ID

P40630 (Mouse), Q00059 (Human), Q0II87 (Bovin), Q5D144 (Pig), Q91ZW1 (Rat)

Gene ID

7019 (TFAM), 21780 (Tfam), 83474

Available reactivities

Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Hu (Human), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Enzyme Immunoassay (E), Frozen Sections (C), Flow Cytometry (F)

Background of TFAM / TCF6 antibody

TFAM(Transcription factor A, mitochondrial), also known as TCF6 or TCF6L2, is a 162-amino acid protein that activates transcription of each mitochondrial DNA (mtDNA) strand by binding to an element of approximately 30 nucleotides present in both the light-strand and the heavy-strand promoters. By Southern blot analysis of restriction enzyme digests of human/Chinese hamster somatic cell hybrid lines, Milatovich et al. (1992) mapped TFAM sequences, which they called MTTF1, to 3 different chromosomes: chromosomes 10, 7p, and 11q. By PCR-based screening of a somatic cell hybrid panel and by fluorescence in situ hybridization, Scott (2007) stated that the sequences mapped to chromosomes 7p (TCF6L1) and 11q (MTTF1, or TCF6L3) are pseudogenes. Larsson et al. (1997) mapped the mouse mitochondrial transcription factor A gene (Tfam) to the central part of mouse chromosome 10. This region exhibits syntenic homology with human 10q21. Mitochondrial transcription factor A is a key activator of mitochondrial transcription in mammals. It also has a role in mitochondrial DNA replication, since transcription generates an RNA primer necessary for initiation of mtDNA replication.

General readings

Sinha RA., et al. (2010) Biochem Biophys Res Commun. 397(3):548-52.
Aquilano K., et al. (2010) J Biol Chem. 285(28):21590-9.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TFAM / TCF6 antibody

  Mouse Monoclonal mtTFA Antibody (18G102B2E11)  
Western Blot: mtTFA Antibody - Western blot analysis of mtTFA expression in HeLa whole cell lysate using anti-mtTFA. Mouse IgG 18G102B2E11 Purified Hu C, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TFAM / TCF6 (C-term) antibody

  Rabbit polyclonal TFAM Antibody (C-term)  
TFAM Antibody (C-term) (Cat. #TA324361) western blot analysis in Hela,Jurkat,K562,MCF-7 cell line lysates (35ug/lane).This demonstrates the TFAM antibody detected the TFAM protein (arrow). Rabbit Ig Aff - Purified Hu F, ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

TFAM / TCF6 antibody

  Rabbit Polyclonal anti-TFAM antibody  
WB Suggested Anti-TFAM Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu, Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

TFAM / TCF6 antibody

  Rabbit anti-TFAM Polyclonal Antibody  
Western blot analysis of extracts of various celllines, using TFAM antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

TFAM / TCF6 antibody

  Rabbit polyclonal anti-TFAM antibody  
Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using TFAM antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TFAM / TCF6 antibody

  Rabbit Polyclonal Anti-TFAM Antibody  
WB Suggested Anti-TFAM Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: NIH/3T3 cell lysate Rabbit IgG Purified Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TFAM / TCF6 antibody

  Rabbit Polyclonal Anti-Tfam Antibody  
WB Suggested Anti-Tfam Antibody Titration: 0.2-1 ug/ml; Positive Control: SP2/0 cell lysate Rabbit IgG Purified Bov, Ms, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

TFAM / TCF6 antibody

  Rabbit Polyclonal Anti-Tfam Antibody - middle region  
WB Suggested Anti-Tfam Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Mouse Muscle Rabbit IgG Purified Ms P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

TFAM / TCF6 antibody

  Rabbit Polyclonal Anti-Tfam Antibody - middle region  
WB Suggested Anti-Tfam Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Mouse Muscle Rabbit IgG Purified Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

TFAM / TCF6 (C-term) antibody

Western blot of rat kidney lysate showing specific immunolabeling of the ~24k TFAM protein. Rabbit Ig Serum Hu, Ms, Rt WB
0.1 ml / €340.00
  Acris Antibodies GmbH

TFAM / TCF6 antibody

Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu E, ICC/IF, P
50 µl / €470.00
  Acris Antibodies GmbH

TFAM / TCF6 antibody

Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using TFAM Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, P
50 µg / €230.00
  Assay Biotech

TFAM / TCF6 antibody

Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using TFAM Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, P
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

TFAM - human gene knockout kit via CRISPR

TFAM - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TFAM - human gene knockout kit via CRISPR

TFAM - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tfam - mouse gene knockout kit via CRISPR

Tfam - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Tfam - mouse gene knockout kit via CRISPR

Tfam - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tfam - mouse gene knockout kit via CRISPR

Tfam - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tfam - mouse gene knockout kit via CRISPR

Tfam - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TFAM / TCF6 (43-246, His-tag)

TFAM / TCF6 Human Purified > 85 % E. coli
50 µg / €750.00
  Acris Antibodies GmbH

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