TFEC antibody

Principal name

TFEC antibody

Alternative names for TFEC antibody

Transcription factor EC, TFE-C, TCFEC, TFECL, TFEC-L, Transcription factor EC-like

SwissProt ID

A4IFU7 (Bovin), O14948 (Human), Q63302 (Rat), Q9WTW4 (Mouse)

Gene ID

22797 (TFEC), 21426 (Tfec), 26296

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine)

Available hosts

Goat, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of TFEC antibody

The DNA-binding factor TFE3 contains adjacent helix-loop-helix (HLH) and leucine zipper (LZ) domains flanked by an upstream basic region. These protein motifs are frequently observed in other transcription factors and are particularly common to members of the Myc family. TFE3 is ubiquitously expressed and can directly associates with DNA as either homodimers or heterodimers formed with two related proteins, TFEB or TFEC. TFE3 binds to and activates the microE3 motif of the immunoglobulin heavy-chain enhancer to induce B-cell-specific gene transcription and DNA recombination. TFEB binds to the major late promoter of adenovirus and specifically associates with DNA as both a homodimer and a heterodimer with TFE3. TFEB is expressed at low levels in the embryo but at high levels in the trophoblast cells of the placenta, where it plays a critical role in regulating normal vascularization of the placenta.
TFEC shares a bHLH/LZ structure with TFE3 and a closely related protein microphthalmia-associated transcription factor (MITF), which is critically involved in melanocyte differentiation. Unlike TFE3, the expression of TFEC is largely restricted to fibroblasts, myoblasts, chondrosarcoma cells, and myeloma cells.

General readings

Yasumoto K, Shibahara S.
Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator.
Biochim Biophys Acta. 1997 Jul 17;1353(1):23-31.
PMID: 9256061

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TFEC (N-term) antibody

  Goat Polyclonal Antibody against TFEC  
TA302789 staining (1µg/ml) of Human Testis lysate (RIPA buffer, 30µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TFEC antibody

  Rabbit polyclonal antibody to TFEC (transcription factor EC)  
Sample (30 ug of whole cell lysate). A: 293T. 10% SDS PAGE. TFEC antibody. TA308363 diluted at 1:1000. Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TFEC antibody

  Rabbit Polyclonal Anti-TFEC Antibody  
WB Suggested Anti-TFEC Antibody Titration: 0.2-1 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

TFEC antibody

AP08822PU-N staining TFEC at 5 µg/ml in paraffin-embedded Spleen by Immunohistochemistry. Goat IgG Aff - Purified Ms, Rt E, P
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

TFEC - human gene knockout kit via CRISPR

TFEC - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TFEC - human gene knockout kit via CRISPR

TFEC - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TFEC - human gene knockout kit via CRISPR

TFEC - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TFEC - human gene knockout kit via CRISPR

TFEC - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TFEC (full length, N-term HIS tag, transcript variant 2)

  Purified recombinant protein of Human transcription factor EC (TFEC), transcript variant 2, full length, with N-terminal HIS tag, expressed in E. coli, 50ug  
TFEC Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

TFEC overexpression lysate

TFEC overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TFEC (mGFP-tagged) - Human transcription factor EC (TFEC), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, TFEC (mGFP-tagged) - Human transcription factor EC (TFEC), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, TFEC (Myc-DDK tagged) - Human transcription factor EC (TFEC), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, TFEC (Myc-DDK tagged) - Human transcription factor EC (TFEC), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Tfec (GFP-tagged) - Mouse transcription factor EC (Tcfec), 200 uL, >10^7 TU/mL

Lenti ORF particles, Tfec (GFP-tagged) - Mouse transcription factor EC (Tcfec), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Tfec (Myc-DDK-tagged) - Mouse transcription factor EC (Tcfec), 200 uL, >10^7 TU/mL

Lenti ORF particles, Tfec (Myc-DDK-tagged) - Mouse transcription factor EC (Tcfec), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Tfec (GFP-tagged ORF) - Rat transcription factor EC (Tfec), 200 uL, >10^7 TU/mL

Lenti ORF particles, Tfec (GFP-tagged ORF) - Rat transcription factor EC (Tfec), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Tfec (Myc-DDK-tagged ORF) - Rat transcription factor EC (Tfec), 200 uL, >10^7 TU/mL

Lenti ORF particles, Tfec (Myc-DDK-tagged ORF) - Rat transcription factor EC (Tfec), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

16 Item(s)

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