TGFB1 antibody

Principal name

TGFB1 antibody

Alternative names for TGFB1 antibody

TGFB, Transforming growth factor beta-1, TGF-beta-1

SwissProt ID

O19011 (Horse), P01137 (Human), P04202 (Mouse), P07200 (Pig), P09531 (Chick), P17246 (Rat), P18341 (Bovin), Q9Z1Y6 (Cavpo)

Gene ID

7040 (TGFB1), 397078, 21803 (Tgfb1), 59086

Available reactivities

Ms (Mouse), Por (Porcine), Rt (Rat), Hu (Human), Sh (Sheep), Bov (Bovine), Can (Canine), Prim (Primate), Eq (Equine), GP (Guinea Pig), Gt (Goat), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Functional assay (FN), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Neutralisation (NEUT)

Background of TGFB1 antibody

Transforming growth factor (TGF), a Â?factorÂ? that promoted the transformation of cultured fibroblasts into a tumor-like phenotype, was subsequently found to be more of a tumor suppressor than tumor promoter and to be a mixture of two proteins, TGF-. and TGF-.. These molecules are members of a superfamily that includes TGF-.1 through 5, bone morphogenic proteins, activins and inhibins. It plays a critical role in cellular growth, development, differentiation, proliferation, extracellular matrix (ECM) synthesis and degradation, control of mesenchymal-epithelial interactions during embryogenesis, immune modulation, apoptosis, cell cycle progression, angiogenesis, adhesion and migration and leukocyte chemotaxis.

Originally, TGF-.1 was separated from platelets and later found that TGF-.1 can be expressed in many organizations. Human TGF-.1 is a 25kDa, disulfide-linked, non-glycosylated homodimer. Biological activity of TGF-.1 is regulated by a number of receptors, including receptor I (53-65KD), receptor II (83-110KD), receptor III (250-310KD), receptor-IV (60KD) and receptor V (400KD).

TGF-.1 is the key mediator in the pathophysiology of tissue repair and human fibrogenesis: balance between production and degradation of type I collagen, and fibrosis and scarring in organ and tissue. TGF-.1 exhibits important immunoregulatory features of partially adverse character: TGF-.1 inhibits B and T cell proliferation, differentiation and antibody production as well as maturation and activation of macrophages. TGF-.1 is synthesized, with only a few exceptions, by virtually all cells, and TGF receptors are expressed by all cells. TGF-. affects nearly every physiological process in some way; its systemic and cell-specific activities are too complicated to review here. There are, however, three fundamental activities: TGF-.1 modulates cell proliferation, generally as a suppressor; TGF-.1 enhances the deposition of extracellular matrix through promotion of synthesis and inhibition of degradation; TGF-.1 is immunosuppressive through a variety of mechanisms. The specific action of TGF-. on a particular cell depends on the exact circumstances of that cellÂ?s environment.

General readings

Kingsley, D.M. (1994) Genes Dev. 8:133.

Javelaud, D. and A. Mauviel (2004) Int. J. Biochem. Cell Biol. 36:1161.

Chang, H. et al. (2002) Endocr. Rev. 23:787.

Kondaiah, P. et al. (1988) J. Biol. Chem. 263:18313.

Clark, D.A. and R. Coker (1998) Int. J. Biochem. Cell Biol. 30:293.

Qian, S.W. et al. (1990) Nucleic Acids Res. 18:3059.

Derynack, R. et al. (1986) J. Biol. Chem. 261:4377.

Dubois, C.M. et al. (1995) J. Biol. Chem. 270:10618.

Manning, A.M. et al. (1995) Gene 155:307.

Brunner, A.M. et al. (1989) J. Biol. Chem. 264:13660.

Mittl, P.R.E. et al. (1996) Protein Sci. 5:1261.

Gray, A.M. and A.J. Mason (1990) Science 247:1328.

Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601.

Saharinen, J. et al. (1996) EMBO J. 15:245.

Mangasser-Stephan, K. and A.M. Gressner (1999) Cell Tissue Res. 297:363.

Koli, K. et al. (2001) J. Cell Sci. 114:2869.

Yang, L. et al. (2000) Wound Rep. Reg. 8:538.

Pedrozo, H.A. et al. (1999) Endocrinology 140:5806.

Yu, Q. and I. Stamenkovic (2000) Genes Dev. 14:163.

Maeda, S. et al. (2001) J. Bone Miner. Res. 16:1281.

Munger, J.S. et al. (1999) Cell 96:319.

Derynck, R. et al. (1985) Nature 316:701.

Derynck, R. and X-H. Feng (1997) Biochim. Biophys. Acta 1333:F105.

Ten Dijke, P. et al. (1996) Curr. Opin. Cell. Biol. 8:139.

Chai, Y. et al. (2003) Crit. Rev. Oral Biol. Med. 14:78.

de Caestecker, M. et al. (2004) Cytokine Growth Factor Rev. 15:1.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TGFB1 antibody

Immunohistochemistry (IHC) analyzes of TGF-beta1 antibody (Cat.-No.: AP06350PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TGFB1 antibody

Western blot result of the antibody used at 2μg/mL to detect platelet derived TGF-β at 12μg/lane (lane 2) 6μg/lane (lane 3), 3 μg/lane (lane 4) and 1μg/mL (lane 5) with 4- chlorol-napthol as substrate. The bottom band is the 12.5KD TGF-β monomer, the mid-band is the 25KD TGF-β dimer and the up band is TGF-β with signal peptide. Lane 1 is molecular weight markers. Mouse IgG1 TB21 Azide Free Hu, Sh C, E, FN, P, WB
0.5 mg / €460.00
  Acris Antibodies GmbH

TGFB1 antibody

  TGFB1 mouse monoclonal antibody, clone OTI1E12 (formerly 1E12)  
Anti-TGFB1 mouse monoclonal antibody (TA506585) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TGFB1(RC200973). Mouse IgG2a OTI1E12 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TGFB1 (N-term) antibody

TGFB1 Antibody (N-term) (AP54230PU-N)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of TGFB1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TGFB1 antibody

  Rabbit anti-TGFB1 polyclonal antibody  
Western blot analysis of A549 cell lysates with anti-TGF beta1 antibody (1:500). Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TGFB1 antibody

  Rabbit polyclonal anti-TGF Beta1 antibody  
Western blot analysis of extracts from HepG2 cells, using TGF ß1 antibody (#TA313319).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TGFB1 (286-293) antibody

  Rabbit polyclonal TGF beta 1 antibody  
WB analysis using Anti-TGF beta 1 antibody to detect human TGF beta 1. Each lane contains 250 ng of protein under non-reducing (lane 1) and reducing conditions (lane 2). Comparison to molecular weight markers (not shown) was used to estimate the indicated molecular weights. The blot was incubated with a 1:200 dilution of the antibody at RT for 1 h followed by detection using IRDye® 800 labeled Goat-a-Rabbit IgG (H&L)  diluted 1:2,500. Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

TGFB1 antibody

  Anti-TGFB1 Rabbit Polyclonal Antibody  
Predicted band size: 44 kDa . Positive control: Mouse heart tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/450 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TGFB1 antibody

  Anti-TGFB1 Rabbit Polyclonal Antibody  
Predicted cell location: Secreted,Cytoplasm. Positive control: Human liver and gastric cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using TGFB1 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TGFB1 antibody

  Rabbit Polyclonal Anti-Tgfb1 Antibody  
WB Suggested Anti-Tgfb1 Antibody Titration: 1.25 ug/ml; Positive Control: Mouse Lymphnode Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Sh WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TGFB1 antibody

  Rabbit Polyclonal Anti-TGF beta1 Antibody  
Western blot analysis of extracts from HepG2 cells, using TGF beta Antibody. The lane on the left is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TGFB1 antibody

  TGFB1 mouse monoclonal antibody, clone OTI3B6 (formerly 3B6)  
Anti-TGFB1 mouse monoclonal antibody (TA506583) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TGFB1(RC200973). Mouse IgG2a OTI3B6 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TGFB1 antibody

  TGFB1 mouse monoclonal antibody, clone OTI2B5 (formerly 2B5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TGFB1 (RC200973, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TGFB1. Mouse IgG2a OTI2B5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TGFB1 antibody

TGFB1 Mouse IgG2a Azide Free Hu E, P, WB
0.5 mg / €220.00
  Acris Antibodies GmbH

TGFB1 antibody

Western blot analysis using TGF beta-1 antibody Cat.-No AM06127SU-N against truncated TGF beta1 recombinant protein. Mouse IgG2a GE 4.90 Ascites Hu E, WB
0.1 ml / €300.00
  Acris Antibodies GmbH

TGFB1 antibody

TGFB1 Mouse IgG1 TB21 Aff - Purified Hu C, E, F, NEUT, P, WB
1.0 ml / €480.00
  Acris Antibodies GmbH

TGFB1 antibody

TGFB1 Mouse IgG1 TB21 PE Hu F
100 Tests / €960.00
  Acris Antibodies GmbH

TGFB1 (286-293) antibody

Figure 1. AP07828PU-N TGFB1 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Spleen at 5 µg/ml, followed by biotinylated Goat anti-Rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Hu E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TGFB1 antibody

TGFB1 Mouse IgG1 2C5 Azide Free Hu E, WB
0.5 mg / €460.00
  Acris Antibodies GmbH

TGFB1 antibody

TGFB1 Mouse IgG1 2C6 Azide Free Hu C, E, FN, WB
0.5 mg / €460.00
  Acris Antibodies GmbH

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