TGFBR1 / ALK-5 antibody

Principal name

TGFBR1 / ALK-5 antibody

Alternative names for TGFBR1 / ALK-5 antibody

TGF-beta receptor type-1, TGF-beta type I receptor, TbetaR-I, TGFR-1, ALK5, SKR4, Transforming growth factor-beta receptor type I, Activin receptor-like kinase 5, Serine/threonine-protein kinase receptor R4

SwissProt ID

O46680 (Bovin), P36897 (Human), P80204 (Rat), Q5CD18 (Pig), Q64729 (Mouse)

Gene ID

7046 (TGFBR1), 21812 (Tgfbr1), 29591

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Por (Porcine), Can (Canine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of TGFBR1 / ALK-5 antibody

TGFBR1, Transforming growth factor, beta receptor I is a TGF beta receptor. TGFBR1 is its human gene. The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). TGFB1 regulates cell cycle progression by a unique signaling mechanism that involves its binding to TGFBR2 and activation of TGFBR1. Both are transmembrane serine/threonine receptor kinases. The TGFBR1 receptor may be inactivated in many of the cases of human tumor cells refractory to TGFB-mediated cell cycle arrest. Vellucci and Reiss (1997) reported that the TGFBR1 gene is approximately 31 kb long and contains 9 exons. The organization of the segment of the gene that encodes the C-terminal portion of the serine/threonine kinase domain appears to be highly conserved among members of the gene family.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TGFBR1 / ALK-5 antibody

Western blot analysis of TGFβ RI Antibody Cat.-No AP01457PU-N at 1/500 dilution.Lane 1: Hela whole cell lysate. Lane 2: LO2 whole cell lysate. Lane 3: Raw264.7 whole cell lysate.Lane 4: Mouse kidney tissue lysate. Lane 5: Rat heat tissue lysate. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

TGFBR1 / ALK-5 (50-63) antibody

  Goat Anti-TGFBR1 (aa50-63) Antibody  
(0.1ug/ml) staining of Rat Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TGFBR1 / ALK-5 antibody

  Rabbit polyclonal TGF Beta Receptor I (Ab-165) antibody  
Western blot analysis of extracts from COLO cells and HepG2 cells, using TGF ß Receptor I (Ab-165) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TGFBR1 / ALK-5 antibody

  Anti-TGFBR1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm . Positive control: Human lung and gastric cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human lung cancer tissue using TGFBR1 antibody at dilution 1/60, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TGFBR1 / ALK-5 antibody

  Anti-TGFBR1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm,Cell membrane. Positive control: Human gastric cancer tissue . Recommended dilution: 1/100-300  The image on the left is immunohistochemistry of paraffin-embedded human gastric cancer tissue using TGFBR1 antibody at dilution 1/70, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TGFBR1 / ALK-5 (Center) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TGFBR1 / ALK-5 (158-179) antibody

Human Placenta (formalin-fixed, paraffin-embedded) stained with TGFBR1 antibody AP22679PU-N at 15 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu P
50 µg / €470.00
  Acris Antibodies GmbH

TGFBR1 / ALK-5 pSer165 antibody

TGFBR1 / ALK-5 Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
0.1 mg / €330.00
  Assay Biotech

TGFBR1 / ALK-5 antibody

Immunofluorescence analysis of HeLa cells, using TGF beta Receptor I (Ab-165) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

TGFBR1 / ALK-5 antibody

Immunofluorescence analysis of HeLa cells, using TGF beta Receptor I (Ab-165) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

TGFBR1 / ALK-5 antibody

TGF Beta R (Type1) staining of paraffin embedded Human colon, ulcerative colitis. Note membrane staining of a proportion of epithelial cells and lymphocytes. Mouse IgM 8A11 Supernatant Hu C, P
0.1 ml / €260.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

TGFBR1 - human gene knockout kit via CRISPR

TGFBR1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TGFBR1 - human gene knockout kit via CRISPR

TGFBR1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TGFBR1 - human gene knockout kit via CRISPR

TGFBR1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TGFBR1 - human gene knockout kit via CRISPR

TGFBR1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tgfbr1 - mouse gene knockout kit via CRISPR

Tgfbr1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Tgfbr1 - mouse gene knockout kit via CRISPR

Tgfbr1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tgfbr1 - mouse gene knockout kit via CRISPR

Tgfbr1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Tgfbr1 - mouse gene knockout kit via CRISPR

Tgfbr1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TGFBR1 / ALK-5 (transcript variant 1)

  Recombinant protein of human transforming growth factor, beta receptor 1 (TGFBR1), transcript variant 1  
TGFBR1 / ALK-5 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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