TGOLN2 / TGN46 antibody

Principal name

TGOLN2 / TGN46 antibody

Alternative names for TGOLN2 / TGN46 antibody

TGN38 homolog, TGN48, TGN51, Golgi Marker, Trans-Golgi network integral membrane protein 2

SwissProt ID

O43493 (Human)

Gene ID

10618 (TGOLN2), 22135 (Tgoln2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Rb (Rabbit), Prim (Primate), Eq (Equine), Gt (Goat)

Available hosts

Rabbit, Sheep, Mouse

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Flow Cytometry (F), Immunoelectron Microscopy (EM)

Background of TGOLN2 / TGN46 antibody

The trans-Golgi network (TGN) is part of the secretory pathway of eukaryotic cells which is distinct from the Golgi stack. The TGN is important in the later stages of protein secretion where it seems to play a key role in the sorting and targeting of secreted proteins to the correct destination. Some surface receptors recycle between the cell surface and the TGN, suggesting that the TGN is also important in endocytic pathways. TGN46 cycles between the trans-Golgi network and the cell surface returning via endosomes. It is thought to be involved in regulating membrane traffic to and from trans-Golgi network. Three splice isoforms are found: TGN46, TGN48 and TGN51. Isoform TGN46 is widely expressed, isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells whilst isoform TGN51 is more abundant in fetal lung and kidney. TGN46 is a human specific protein. The rodent homologue of TGN46 is known as TGN38.

General readings

This product has been used in:Horn M & Banting G Okadaic acid treatment leads to a fragmentation of the trans-Golgi network and an increase in expression of TGN38 at the cell surface. Biochem J 301 (Pt 1):69-73 (1994). PubMed PMID: 8037693
General / background references:Stephens DJ & Banting G Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin. J Biol Chem 274:30080-6 (1999). PubMed PMID: 10514494
Greenfield JP et al. Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. Proc Natl Acad Sci U S A 96:742-7 (1999). PubMed PMID: 9892704
Reaves B & Banting G Vacuolar ATPase inactivation blocks recycling to the trans-Golgi network from the plasma membrane. FEBS Lett 345:61-6 (1994). PubMed PMID: 8194602
Luzio JP et al. Identification, sequencing and expression of an integral membrane protein of the trans-Golgi network (TGN38). Biochem J 270:97-102 (1990). PubMed PMID: 2204342

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TGOLN2 / TGN46 antibody

Immunofluorescence staining of Human TGN46 in 3% paraformaldehyde fixed HeLa cells using Rabbit anti-Human TGN46 Antibody Serum Cat.-No AP32690SU-N at 1/100. Secondary antibody was Goat anti-Rabbit Alexa Fluor 488. Rabbit Serum Hu, Prim EM, ICC/IF, WB
0.1 ml / €300.00
  Acris Antibodies GmbH

TGOLN2 / TGN46 antibody

Immunofluorescence staining of Human TGN46 in 3% paraformaldehyde-fixed HeLa cells using Affinity purified Sheep anti-Human TGN46 Antibody Cat.-No AP32693PU-N at 1/100. Secondary antibody was Donkey anti-Sheep Alexa Fluor 488. Sheep IgG Purified Hu, Prim EM, ICC/IF, WB
0.1 ml / €350.00
  Acris Antibodies GmbH

TGOLN2 / TGN46 antibody

Immunofluorescence staining of Hhuman TGN46 in 3% paraformaldehyde-fixed HeLa cells using Sheep anti-Human TGN46 Antibody Serum Cat.-No AP32693SU-N at 1/100. Secondary antibody was Donkey anti-Sheep Alexa Fluor 488. Sheep Serum Hu, Prim C, ICC/IF, IP, WB
0.1 ml / €300.00
  Acris Antibodies GmbH

TGOLN2 / TGN46 antibody

Immunohistochemistry: TGN46 Antibody - Golgi Apparatus marker - Immunohistochemical analysis of TGOLN2 in human renal cell carcinoma. Rabbit Purified Hu C, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

TGOLN2 / TGN46 antibody

WB Suggested Anti-TGOLN2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human Stomach Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

TGOLN2 / TGN46 antibody

Host: Rabbit; Target Name: TGOLN2; Sample Tissue: OVCAR-3 Whole Cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Eq, Gt, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TGOLN2 / TGN46 antibody

TGOLN2 / TGN46 Sheep IgG Purified Ms, Rt C, WB
25 µg / €640.00
  Acris Antibodies GmbH

TGOLN2 / TGN46 antibody

TGOLN2 / TGN46 Sheep IgG Serum Ms, Rt C, WB
0.1 ml / €640.00
  Acris Antibodies GmbH

TGOLN2 / TGN46 antibody

TGOLN2 / TGN46 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

TGOLN2 / TGN46 antibody

Immunoperoxidase of monoclonal antibody to TGOLN2 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml] Mouse IgG2a 2F11 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

TGOLN2 / TGN46 antibody

TGOLN2 / TGN46 Sheep Hu C, ICC/IF, P, WB
10 µg / €390.00
  Abnova Taiwan Corp.

TGOLN2 / TGN46 antibody

TGOLN2 / TGN46 Sheep Hu ICC/IF, P, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

TGOLN2 / TGN46 antibody

TGOLN2 / TGN46 Rabbit Hu C, ICC/IF, P, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

TGOLN2 / TGN46 antibody

Human Liver; Liver; TGOLN2 antibody - N-terminal region (ARP46727_P050) in Human Liver cells using Immunohistochemistry Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

TGOLN2 / TGN46 antibody

Immunofluorescence: TGN38 Antibody (2F7.1) [NB300-575] - HeLa and COS7 cells were rinsed with PBS and fixed with -20°C methanol for 5 minutes. Cells were incubated with anti-TGN38 antibody (NB300-575) diluted 1:100 in PBS containing 0.2%BSA for 1 hour. The cells were then rinsed in PBS and incubated with goat anti-mouse IgG conjugated to rhodamine for 30 minutes in PBS containing 0.2% BSA. Following washing, cells were imaged using a Zeiss Axioplan microscope. Mouse IgG1 2F7.1 Ascites Hu, Mky, Rb, Rt F, ICC/IF, IP, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

TGOLN2 / TGN46 antibody

TGOLN2 / TGN46 Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.5 mg / €400.00
  Novus Biologicals Inc.

TGOLN2 / TGN46 antibody

TGOLN2 / TGN46 Sheep Serum Hu, Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

TGOLN2 / TGN46 antibody

TGOLN2 / TGN46 Rabbit Aff - Purified Hu ICC/IF, P
0.1 ml / €360.00
  Novus Biologicals Inc.

TGOLN2 / TGN46 antibody

TGOLN2 / TGN46 Rabbit Aff - Purified Hu ICC/IF, P
0.1 ml / €390.00
  Novus Biologicals Inc.

TGOLN2 / TGN46 antibody

TGOLN2 / TGN46 Rabbit Aff - Purified Hu ICC/IF, P
0.1 ml / €390.00
  Novus Biologicals Inc.

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