THEM4 / CTMP antibody

Principal name

THEM4 / CTMP antibody

Alternative names for THEM4 / CTMP antibody

Thioesterase superfamily member 4, Carboxyl-terminal modulator protein

SwissProt ID

A1A4L1 (Bovin), Q3UUI3 (Mouse), Q566R0 (Rat), Q5T1C6 (Human)

Gene ID

117145 (THEM4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection))

Background of THEM4 / CTMP antibody

THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program. The additional higher molecular weight bands seen in the immunoblot may represent post-translationally modified TMEM4.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

THEM4 / CTMP antibody

Western blot analysis of THEM4 in human liver tissue lysate with THEM4 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

THEM4 / CTMP antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

THEM4 / CTMP Control Peptide

THEM4 / CTMP
50 µg / €160.00
  Acris Antibodies GmbH

THEM4 / CTMP antibody

Western Blot analysis of THEM4 expression in transfected 293T cell line (H00117145-T01) by THEM4 MaxPab polyclonal antibody.

Lane 1: THEM4 transfected lysate(26.4 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

THEM4 / CTMP antibody

THEM4 / CTMP Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €480.00
  Novus Biologicals Inc.

THEM4 / CTMP antibody

Immunohistochemistry-Paraffin: THEM4 Antibody [NBP1-77360] - Human liver tissue with THEM4 antibody at 2.5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

THEM4 / CTMP antibody

Immunohistochemistry-Paraffin: THEM4 Antibody [NBP1-84336] - Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

THEM4 / CTMP

THEM4 / CTMP Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

THEM4 / CTMP

THEM4 / CTMP Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

THEM4 / CTMP

THEM4 / CTMP Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

THEM4 / CTMP

THEM4 / CTMP Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

THEM4 293T Cell Transient Overexpression Lysate(Denatured)

THEM4 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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