THEM4 / CTMP antibody

Principal name

THEM4 / CTMP antibody

Alternative names for THEM4 / CTMP antibody

Thioesterase superfamily member 4, Carboxyl-terminal modulator protein

SwissProt ID

A1A4L1 (Bovin), Q3UUI3 (Mouse), Q566R0 (Rat), Q5T1C6 (Human)

Gene ID

117145 (THEM4), 75778 (Them4), 361992

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of THEM4 / CTMP antibody

THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program. The additional higher molecular weight bands seen in the immunoblot may represent post-translationally modified TMEM4.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

THEM4 / CTMP antibody

  Rabbit Polyclonal THEM4 Antibody  
Western blot analysis of THEM4 in human liver tissue lysate with THEM4 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

THEM4 / CTMP antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Them4 - mouse gene knockout kit via CRISPR

Them4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Them4 - mouse gene knockout kit via CRISPR

Them4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Them4 - mouse gene knockout kit via CRISPR

Them4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Them4 - mouse gene knockout kit via CRISPR

Them4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Them4 (GFP-tagged) - Mouse thioesterase superfamily member 4 (Them4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Them4 (GFP-tagged) - Mouse thioesterase superfamily member 4 (Them4), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Them4 (Myc-DDK-tagged) - Mouse thioesterase superfamily member 4 (Them4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Them4 (Myc-DDK-tagged) - Mouse thioesterase superfamily member 4 (Them4), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Them4 (GFP-tagged ORF) - Rat thioesterase superfamily member 4 (Them4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Them4 (GFP-tagged ORF) - Rat thioesterase superfamily member 4 (Them4), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Them4 (Myc-DDK-tagged ORF) - Rat thioesterase superfamily member 4 (Them4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Them4 (Myc-DDK-tagged ORF) - Rat thioesterase superfamily member 4 (Them4), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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