Thioredoxin / TRX1 antibody

Principal name

Thioredoxin / TRX1 antibody

Alternative names for Thioredoxin / TRX1 antibody

TXN, TRDX, TRX, ATL-derived factor, ADF, SASP, Surface-associated sulphydryl protein

SwissProt ID

O97680 (Bovin), P08628 (Rabit), P08629 (Chick), P10599 (Human), P10639 (Mouse), P11232 (Rat), P50413 (Sheep)

Gene ID

7295 (TXN), 22166 (Txn1), 116484

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), E. coli (Escherichia coli), Bov (Bovine), Por (Porcine), Rb (Rabbit), Can (Canine), Eq (Equine), GP (Guinea Pig), Sh (Sheep)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of Thioredoxin / TRX1 antibody

Thioredoxin (TRX) is a small ubiquitous protein (12 kDa) which is exist in a wide activity of prokaryotic and eukaryotic cells. TRX is activated by reducing its disulfide group (-S-S- → 2SH) between cysteine residues within the conserved active site sequence: -Cys-Gly-Pro-Cys-. The reduction of TRX is specifically catalyzed by “TRX reductase”, a FAD and selenocystein containing protein, using NADPH. Once reduced, TRX in turn reduces disulfide bonds of various proteins to regulate the activity of the protein (redox regulation). TRX has multiple biological function; Activation of transcripti on factors such as NF- κ B and glucocotricoid receptor, anti-apoptotic function, stimulation of cytokine expression, tissue protection from ischemia-reperfusion injury, cytoprotection from cytotoxic and DNA-damaging agents, proliferation, and drug resistance in certain malignancies. A part of these functions are due to TRX which exported out of the cell where it has additional ability to stimulate cell growth, cytoprotection, and co-cytokine activity. It is said that some of above TRX functions are related to response against the cellular “stresses”. In fact, TRX is translocated from the cytosol into the nucleus and/or highly expressed by various stress such as UV irradiation and viral infection. So, it is suggested that TRX may have a role in the cellular responses against the stresse s through the regulation of intracellular redox (oxidation-reduction) atatus.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Thioredoxin / TRX1 antibody

  Anti-TXN Rabbit Polyclonal Antibody  
Predicted band size: 12 kDa. Positive control: Hela cell and human liver cancer tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 12%SDS-PAGE Lane1: Hela cell tissue lysate Lane2: Human liver cancer tissue lysate Lysates: 40 ug per lane Primary antibody: 1/700 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Thioredoxin / TRX1 antibody

  Anti-TXN Rabbit Polyclonal Antibody  
Predicted band size: 12 kDa. Positive control: Hela and MCF7 cell, human liver cancer tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 12%SDS-PAGE Lane1: Hela cell tissue lysate Lane2: MCF7 cell tissue lysate Lane3: Human liver cancer tissue lysate Lysates: 40 ug per lane Primary antibody: 1/600 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Thioredoxin / TRX1 antibody

  Anti-TXN Rabbit Polyclonal Antibody  
Predicted band size: 12 kDa. Positive control: A172 and hela cell lysate. Recommended dilution: 1/200-1000. (Gel: 12%SDS-PAGE Lane1: A172 cell lysate lysate Lane2: Hela cell lysate lysate Lysates: 40 ug per lane Primary antibody: 1/200 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 30 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Thioredoxin / TRX1 antibody

  Anti-TXN Rabbit Polyclonal Antibody  
Predicted band size: 12 kDa. Positive control: A172 and hela cell lysate. Recommended dilution: 1/200-1000. (Gel: 12%SDS-PAGE Lane1: A172 cell lysate Lane2: Hela cell lysate Lysates: 40 ug per lane Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Thioredoxin / TRX1 antibody

  Rabbit polyclonal TXN Antibody (C-term)  
TXN Antibody (C-term) (Cat. #TA325133) western blot analysis in A549,MDA-MB453 cell line lysates (35ug/lane).This demonstrates the TXN antibody detected the TXN protein (arrow). Rabbit IgG RB42816 Purified Bov, Hu, Ms, Por, Rb, Rt WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Thioredoxin / TRX1 antibody

  Rabbit Polyclonal Anti-TXN Antibody  
Host: Rabbit; Target Name: TXN; Sample Tissue: MCF7 Whole Cell lysates; Antibody Dilution: 1.0ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

Thioredoxin / TRX1 (TRX-tag) antibody

Western blot analysis using Trx antibody Cat.-No AM06168SU-N against various fusion protein with Trx tag. Mouse IgG1 1H6H6 Ascites Hu WB
0.1 ml / €300.00
  Acris Antibodies GmbH

Thioredoxin / TRX1 antibody

Thioredoxin / TRX1 Mouse IgG1 2C9 Azide Free E. coli WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Thioredoxin / TRX1 antibody

Western blot analysis of human Thioredoxin expression in Raji (1), HeLa (2), WR19L (3) and PC12 (4) using AM26612AF-N. Mouse IgG2a 2E3 Azide Free Hu WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Thioredoxin / TRX1 (N-term) antibody

Western blot analysis of anti-TrX antibody  (Cat.#AP11336PU-N) in HL-60 cell line lysate. TrX(arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Thioredoxin / TRX1 antibody

Human Lung (formalin-fixed, paraffin-embedded) stained with TXN antibody AP22618PU-N at 1/200 followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit IgG Purified Hu, Ms, Rt P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Thioredoxin / TRX1 antibody

Thioredoxin / TRX1 Mouse IgG1 2B1 Purified Hu C, E, P, WB
0.2 mg / €670.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Txn1 - mouse gene knockout kit via CRISPR

Txn1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Txn1 - mouse gene knockout kit via CRISPR

Txn1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Txn1 - mouse gene knockout kit via CRISPR

Txn1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Txn1 - mouse gene knockout kit via CRISPR

Txn1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

TXN - human gene knockout kit via CRISPR

TXN - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TXN - human gene knockout kit via CRISPR

TXN - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TXN - human gene knockout kit via CRISPR

TXN - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TXN - human gene knockout kit via CRISPR

TXN - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

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