THRA / ERBA1 antibody

Principal name

THRA / ERBA1 antibody

Alternative names for THRA / ERBA1 antibody

Thyroid hormone receptor alpha, THRA1, THRA2, C-erbA-alpha, c-erbA-1, EAR-7, EAR7, NR1A1, Nuclear receptor subfamily 1 group A member 1

SwissProt ID

P10827 (Human)

Gene ID

7067 (THRA)

Available reactivities

Chk (Chicken), Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), Sh (Sheep), Xen (Xenopus), Eq (Equine), Hst (Hamster), Mky (Monkey)

Available hosts

Rabbit, Mouse, Goat

Available applications

Electrophoretic Mobility Shift Assay (EMSA), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of THRA / ERBA1 antibody

Thyroid hormone nuclear receptors (TRs) are ligand-dependent transcription factors which regulate growth, differentiation and development and represent members of the steroid/retinoic acid superfamily. The two genes encoding TRs identified to date, TRalpha and TRbeta, have been mapped to human chromosomes 17 and 3, respectively. TRs bind to thyroid hormone response elements (TREs) with half-site binding motifs in the orientation of palindromes, direct repeats or inverted palindromes. The affinities of binding are both variable and influenced differentially by 3,5,3'-triiodo-L-thyronine (T3). Transcriptional regulation by TRs is also modulated by heterodimerization with TR nuclear accessory proteins, the most extensively characterized of which are the retinoid X receptors (RXRalpha, RXRbeta and RXRgamma). To a certain extent, this activity is regulated by differential phosphorylation of TRs. Thus, not only are the biological activities of TRs regulated by heterodimerization with RXRs, but in addition, the gene regulatory activities of TRs are linked to other hormonal pathways. TRalpha1 can display both a nuclear and undefined cytoplasmic location, and is the only TR that is imported into the mitochondrial matrix.

General readings

Nishiyama K, Baba S, Yamada T, Matsushita A, Natsume H, Nakano K, Sasaki S, Nakamura H.
Embryonic lethal effect of expressing a dominant negative mutant human thyroid hormone receptor alpha1 in mice.
Endocr J. 2003 Oct;50(5):561-70.
PMID: 14614212

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

THRA / ERBA1 (alpha-1 + alpha-2) antibody

AP15818PU THR alpha1/2 antibody staining of Human Thyroid. Rabbit Purified Hu, Ms, Por, Rt P
1 ml / €440.00
  Acris Antibodies GmbH

THRA / ERBA1 (alpha-1 + alpha-2) antibody

AP15818PU THR alpha1/2 antibody staining of Human Thyroid. Rabbit Purified Hu, Ms, Por, Rt P
0.1 ml / €180.00
  Acris Antibodies GmbH

THRA / ERBA1 (alpha-1 + alpha-2) antibody

AP15818PU THR alpha1/2 antibody staining of Human Thyroid. Rabbit Purified Hu, Ms, Por, Rt P

Regular Price: 50 µl / €80.00

Special Price: 50 µl / €56.00

  Acris Antibodies GmbH

THRA / ERBA1 antibody

TA303267 (0.5µg/ml) staining of Human Bone Marrow lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

THRA / ERBA1 antibody

Sample (30 ug of whole cell lysate). A: JurKat. 10% SDS PAGE. TA308957 diluted at 1:1000. Rabbit IgG Aff - Purified Hu ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

THRA / ERBA1 (a1/a2) antibody

Western blot of hippocampal lysate showing specific immunolabeling of the ~50k TR-α1 and the ~58k TR-α2 protein. Mouse IgG1 2103 Aff - Purified Can, Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

THRA / ERBA1 (a1/a2) antibody

Western blot of hippocampal lysate showing specific immunolabeling of the ~50k TR-α1 and the ~58k TR-α2 protein. Mouse IgG2a 1718 Aff - Purified Can, Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

THRA / ERBA1 (Alpha-2) antibody

Western blot of hippocampal lysate showing specific immunolabeling of the ~58k TR-α2 protein. Mouse IgG1 1330 Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

THRA / ERBA1 antibody

Western blot analysis of extracts from SKOV3 cells, using Thyroid Hormone Receptor a antibody (#TA313020).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

THRA / ERBA1 antibody

WB using Anti-THRA antibody shows detection of purified recombinant THRA (lane 1) and THRA present in a 293 cell lysate after transient transfection with THRA (lane 3). No staining is evident in lysates from mock-transfected 293 cells (lane 2). Endogenous THRA is not detected in mouse brain whole cell lysate (lane 4). Nuclear extracts may be required to detect endogenous THRA as the protein localizes within the nucleus. The band at ~55 kDa, indicated by the arrowhead, corresponds to THRA. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

THRA / ERBA1 (Ligand bdg. Dom.) antibody

Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Can, Eq, Hst, Hu, Mky, Ms, Por, Rb, Rt, Sh P
50 µg / €379.00
  OriGene Technologies, Inc.

THRA / ERBA1 (Ligand bdg. Dom.) antibody

Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Eq, Hst, Hu, Mky, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

THRA / ERBA1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY THRA (RC203210, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-THRA. Mouse IgG1 OTI6B7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

THRA / ERBA1 antibody

HEK293T cells were transfected with the pCMV6-AC-GFP control (Left lane) or pCMV6-AC-GFP  THRA (RC203210, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-THRA. Mouse IgG2a OTI5A8 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

THRA / ERBA1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY THRA (RC203210, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-THRA. Mouse IgG1 OTI7G2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

THRA / ERBA1 antibody

Immunohistochemical staining of paraffin-embedded Human Ovary tissue within the normal limits using anti-THRA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA805187) Mouse IgG1 OTI2A2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

THRA / ERBA1 antibody

Immunohistochemical staining of paraffin-embedded Human Ovary tissue within the normal limits using anti-THRA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA805188) Mouse IgG1 OTI3E10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

THRA / ERBA1 antibody

HEK293T cells were transfected with the pCMV6-AC-GFP control (Left lane) or pCMV6-AC-GFP  THRA (RC203210, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-THRA. Mouse IgG1 OTI5E12 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

THRA / ERBA1 antibody

HEK293T cells were transfected with the pCMV6-AC-GFP control (Left lane) or pCMV6-AC-GFP THRA (RC203210, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-THRA. Mouse IgG1 OTI5C12 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

THRA / ERBA1 (alpha-2) antibody

THRA / ERBA1 Mouse IgG1 1330 Purified Bov, Can, Hu, Ms, Rt WB
0.1 ml / €490.00
  Acris Antibodies GmbH

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