Thymidine phosphorylase (TYMP) antibody

Principal name

Thymidine phosphorylase (TYMP) antibody

Alternative names for Thymidine phosphorylase (TYMP) antibody

TdRPase, PD-ECGF, ECGF1, Gliostatin, Platelet-derived endothelial cell growth factor

SwissProt ID

P19971 (Human), Q5FVR2 (Rat), Q99N42 (Mouse)

Gene ID

1890 (TYMP)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of Thymidine phosphorylase (TYMP) antibody

Thymidine phosphorylase (TP) is a platelet-derived endothelial cell growth factor (PD-ECGF) that catalyzes the formation of thymine and 2-deoxy-D-ribose-1-phosphate from thymidine and orthophosphate. This intracellular enzyme is capable of both promoting angiogenesis and inhibiting apoptosis. Thymidine phosphorylase catalytic activity is required for its angiogenic function. Increased expression of TP/PD-ECGF is seen in a wide variety of different solid tumors and inflammatory diseases and is often associated with poor prognosis. Altertively, TP can activate fluorouracil derivative (DFUR) prodrugs and increase the antitumor activity of the related treatment. The use of thymidine phosphorylase as a cancer therapeutic target has been studied extensively, with emphasis on either inhibiting TP enzymatic activity or increasing enzyme induction with concomitant DFUR treatment.

General readings

General / background references:Giatromanolaki A et al. Platelet-derived endothelial cell growth factor (thymidine phosphorylase) expression in lung cancer. J Pathol 181:196-9 (1997). PubMed PMID: 9120725
Koukourakis MI et al. Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small-cell lung cancer. Br J Cancer 75:477-81 (1997). PubMed PMID: 9052396
Fox SB et al. Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF. Ann Oncol 8:271-5 (1997). PubMed PMID: 9137797
O'Brien TS et al. Expression of the angiogenic factor thymidine phosphorylase/platelet-derived endothelial cell growth factor in primary bladder cancers. Cancer Res 56:4799-804 (1996). PubMed PMID: 8841001
Fox SB et al. The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase is up-regulated in breast cancer epithelium and endothelium. Br J Cancer 73:275-80 (1996). PubMed PMID: 8562330
Dada MA et al. Thymidine phosphorylase expression in Kaposi sarcoma. J Clin Pathol 49:400-2 (1996). PubMed PMID: 8707955
Moghaddam A et al. Thymidine phosphorylase is angiogenic and promotes tumor growth. Proc Natl Acad Sci U S A 92:998-1002 (1995). PubMed PMID: 7532308
Fox SB et al. Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study. J Pathol 176:183-90 (1995). PubMed PMID: 7636628

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Thymidine phosphorylase (TYMP) antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-TYMP mouse monoclonal antibody. (UM800021; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB90 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Thymidine phosphorylase (TYMP) antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-TYMP mouse monoclonal antibody. (UM800027; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB97 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Thymidine phosphorylase (TYMP) antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-TYMP mouse monoclonal antibody. (UM800028; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB98 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Thymidine phosphorylase (TYMP) antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-TYMP mouse monoclonal antibody. (UM800021; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB90 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Thymidine phosphorylase (TYMP) antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-TYMP mouse monoclonal antibody. (UM800027; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB97 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Thymidine phosphorylase (TYMP) antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-TYMP mouse monoclonal antibody. (UM800028; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB98 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Thymidine phosphorylase (TYMP) antibody

Western blot analysis of extracts of various cell lines, using TYMP antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Thymidine phosphorylase (TYMP) antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-TYMP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800959) Mouse IgG1 OTI1E7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Thymidine phosphorylase (TYMP) antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-TYMP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800979) Mouse IgG1 OTI1H7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Thymidine phosphorylase (TYMP) antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-TYMP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800998) Mouse IgG1 OTI7A6 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Thymidine phosphorylase (TYMP) antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-TYMP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800999) Mouse IgG1 OTI5B5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Thymidine phosphorylase (TYMP) antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-TYMP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801109) Mouse IgG1 OTI7B4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Thymidine phosphorylase (TYMP) antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-TYMP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800961) Mouse IgG1 OTI1G10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Thymidine phosphorylase (TYMP) antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-TYMP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800978) Mouse IgG1 OTI1H10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Thymidine phosphorylase (TYMP) antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TYMP (RC202170, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TYMP. Mouse IgG1 OTI4D4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Thymidine phosphorylase (TYMP) antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TYMP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801080) Mouse IgG1 OTI5B11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Thymidine phosphorylase (TYMP) antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-TYMP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801096) Mouse IgG1 OTI4F4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Thymidine phosphorylase (TYMP) (Center) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ECGF1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Thymidine phosphorylase (TYMP) antibody

Formalin fixed paraffin embedded human breast carcinoma stained with Thymidine Phosphorylase antibody DM292 / DM292-05 Mouse IgG1 P-GF.44C Purified Hu, Ms, Rt P, WB
1 ml / €660.00
  Acris Antibodies GmbH

Thymidine phosphorylase (TYMP) antibody

Formalin fixed paraffin embedded human breast carcinoma stained with Thymidine Phosphorylase antibody DM292 / DM292-05 Mouse IgG1 P-GF.44C Purified Hu, Ms, Rt P, WB
0.5 ml / €430.00
  Acris Antibodies GmbH

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