Thyrotropin receptor / TSHR antibody

Principal name

Thyrotropin receptor / TSHR antibody

Alternative names for Thyrotropin receptor / TSHR antibody

Thyroid-stimulating hormone receptor, TSH-receptor, TSH-R, LGR3

SwissProt ID

P14763 (Canfa), P16473 (Human), P21463 (Rat), P47750 (Mouse), P56495 (Sheep), Q27987 (Bovin), Q8SPP9 (Pig)

Gene ID

7253 (TSHR), 22095 (Tshr)

Available reactivities

Hu (Human), Por (Porcine), Fe (Feline), Mky (Monkey), Bear, Bt (Bat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Hst (Hamster), Ms (Mouse), Op (Opossum), Rb (Rabbit), Rt (Rat), Sh (Sheep), Chk (Chicken)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Thyrotropin receptor / TSHR antibody

The glycoprotein hormone receptor family consists of the luteinizing hormone receptor, the follicle-stimulating hormone receptor, and the thyroid stimulating hormone(TSH) receptor. TSH, which is released from the pituitary gland, binds to the TSH receptor on thyroid cells to control size and function of the thyroid gland (De Felice et al. 2004). The TSH receptor signals through Gs to elevate intracellular cAMP in the thyroid gland, which regulates iodide uptake, and transcription of thyroglobulin (Tg), thyroid peroxidase (TPO), and sodium-iodide symporter. The TSH receptor also signals Gq and phospholipase C to regulat iodide efflux, H2O2 production, and thyroglobulin iodination. Autoimmunity to the TSH receptor causes hyperthyroidism (Graves disease) or hypothyroidism (Hashimoto thyroiditis) when the auto function as agonists or antagonists, respectively, at the TSH receptor (Rapoport and McLachlan, 2001; Davies et al., 2002). Millipore’s cloned human TSH receptor-expressing cell line is made in the Chem-10 host, which supports high levels of recombinant TSH receptor expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between TSH and its ligands.

General readings

This product has been used in:Seetharamaiah GS et al. Generation and characterization of monoclonal antibodies to the human thyrotropin (TSH) receptor: antibodies can bind to discrete conformational or linear epitopes and block TSH binding. Endocrinology 136:2817-24 (1995). PubMed PMID: 7540542
General / background references:Patibandla SA et al. Differential reactivities of recombinant glycosylated ectodomains of mouse and human thyrotropin receptors with patient autoantibodies. Endocrinology 138:1559-66 (1997). PubMed PMID: 9075716
Wagle NM et al. Thyrotropin receptor-specific antibodies in BALB/cJ mice with experimental hyperthyroxinemia show a restricted binding specificity and belong to the immunoglobulin G1 subclass. Endocrinology 136:3461-9 (1995). PubMed PMID: 7628382
Akamizu T et al. Molecular studies on thyrotropin (TSH) receptor and anti-TSH receptor antibodies. Endocr J 42:617-27 (1995). PubMed PMID: 8574284

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Thyrotropin receptor / TSHR (101-115) antibody

(0.5ug/ml) staining of Human Thyroid gland lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Thyrotropin receptor / TSHR antibody

Predicted cell location: Cytoplasm. Positive control: Human thyroid and lung cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using TSHR antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Thyrotropin receptor / TSHR antibody

Predicted cell location: Cytoplasm. Positive control: Human liver cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using TSHR antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Thyrotropin receptor / TSHR (N-term., Extracell. Dom.) antibody

Anti-TSH Receptor antibody IHC of human thyroid, follicular epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Fe, Hu, Mky P
50 µg / €379.00
  OriGene Technologies, Inc.

Thyrotropin receptor / TSHR (C-term) antibody

Anti-TSH Receptor antibody IHC of human thyroid, follicular epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bt, Elephant, Eq, GP, Hu, Mky, Por P
50 µg / €379.00
  OriGene Technologies, Inc.

Thyrotropin receptor / TSHR (C-term) antibody

Anti-TSH Receptor antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Can, Eq, Fe, Hu, Mky, Por, Rb, Sh P
50 µg / €379.00
  OriGene Technologies, Inc.

Thyrotropin receptor / TSHR antibody

Anti-TSH Receptor antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Hu, Mky, Por
50 µg / €379.00
  OriGene Technologies, Inc.

Thyrotropin receptor / TSHR antibody

SM1348P TSHR antibody staining of Paraffin Embedded Human thyroid. Mouse IgG2a 4C1 Purified Hu C, F, IP, P, WB

Regular Price: 0.2 mg / €540.00

Special Price: 0.2 mg / €350.00

  Acris Antibodies GmbH

Thyrotropin receptor / TSHR antibody

Thyrotropin receptor / TSHR Mouse IgG1 2C11 Purified Hu E, F, IP, P, WB
0.2 mg / €670.00
  Acris Antibodies GmbH

Thyrotropin receptor / TSHR antibody

human thryoid; . Sample Type: Nthy-ori cell lysate (50ug). Primary Dilution: 1:1000. Secondary Antibody: anti-rabbit HRP. Secondary Dilution: 1:2000. Image Submitted By: Anonymous .; TSHR antibody - N-terminal region (ARP41720_P050) in human thryoid cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Thyrotropin receptor / TSHR antibody

Human HepG2; WB Suggested Anti-TSHR Antibody Titration: 0.2-1 ug/ml. Positive Control: HepG2 cell lysate; TSHR antibody - N-terminal region (ARP41721_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Thyrotropin receptor / TSHR antibody

Jurkat; Host: Rabbit. Target Name:TSHR. Sample Tissue:Jurkat. Lane A: Primary Antibody . Lane B: Primary Antibody + Blocking Peptide . Primary Antibody Concentration:2.5ug/mL. Peptide Concentration: 2.0ug/mL. Lysate Quantity: 25ug/lane. Gel Concentration: 12%. There is BioGPS gene expression data showing that TSHR is expressed in Jurkat.; TSHR antibody - N-terminal region (ARP41870_T100) in Jurkat cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

Thyrotropin receptor / TSHR antibody

Human Jurkat; WB Suggested Anti-TSHR Antibody Titration: 0.2-1 ug/ml. Positive Control: Jurkat cell lysate. There is BioGPS gene expression data showing that TSHR is expressed in Jurkat.; TSHR antibody - C-terminal region (ARP41871_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Thyrotropin receptor / TSHR antibody

Thyrotropin receptor / TSHR Rabbit IgG Aff - Purified Hu P, WB
0.1 mg / €290.00
  Boster Immunoleader

Thyrotropin receptor / TSHR antibody

Thyrotropin receptor / TSHR Mouse IgG2a 3A6 Purified Hu F
50 µg / €700.00
  Funakoshi Co., Ltd.

Thyrotropin receptor / TSHR antibody

Thyrotropin receptor / TSHR Mouse IgG2a 4C1 Aff - Purified Hu C, F, P
20 µg / €340.00
  Novus Biologicals Inc.

Thyrotropin receptor / TSHR antibody

Thyrotropin receptor / TSHR Mouse IgG2a 28 Ascites Hu, Por E, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Thyrotropin receptor / TSHR antibody

Thyrotropin receptor / TSHR Mouse IgG1 49 Ascites Hu, Por E, ICC/IF, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Thyrotropin receptor / TSHR antibody

Immunohistochemistry-Paraffin: TSH Receptor Antibody [NBP1-87823] Immunohistochemical staining of human kidney shows strong membranous positivity of cells in tubules. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Thyrotropin receptor / TSHR antibody

Thyroid, Follicular Epithelium Rabbit Aff - Purified Hu P
50 µl / €440.00
  Novus Biologicals Inc.

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