TIA1 antibody

Principal name

TIA1 antibody

Alternative names for TIA1 antibody

Nucleolysin TIA-1, p40-TIA-1, p15-TIA-1, RNA-binding protein TIA-1, TIA1 cytotoxic granule-associated RNA binding protein

SwissProt ID

P31483 (Human), P52912 (Mouse)

Gene ID

7072 (TIA1), 5395 (PMS2)

Available reactivities

Hu (Human), Bov (Bovine), Chk (Chicken), Ms (Mouse), Rt (Rat), Can (Canine), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Goat, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Frozen Sections (C)

Background of TIA1 antibody

TIA1 is a member of an RNA binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
TIA-1 (T-cell intracytoplasmic antigen) monoclonal antibody reacts with a 15 kDa cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. The expression of TIA-1 was studied in CD30+ anaplastic large cell lymphomas (ALCL), NK cell lymphomas and peripheral T-cell lymphomas and T cell lymphocytosis, B-cell lymphomas and lymphoblastic leukemia, Hodgkin’s etc. Studies showed that 60 to 70% of anaplastic large cell lymphoma reacted with TIA-1. Studies also indicate that TIA-1 reacts with most large granular lymphocytic leukemia's, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas, pulmonary angiocentric lymphomas of T or NK phenotype. The author's concluded from TIA-1 studies that anaplastic large-cell lymphomas are cytotoxic T-or NK-cell neoplasms. All B-cell lymphomas, Hodgkin's and lymphoblastic leukemias were negative for TIA-1.

General readings

Yang F, Peng Y, Murray EL, Otsuka Y, Kedersha N, Schoenberg DR.
Polysome-bound endonuclease PMR1 is targeted to stress granules via stress-specific binding to TIA-1.
Mol Cell Biol. 2006 Dec;26(23):8803-13. Epub 2006 Sep 18.
PMID: 16982678

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TIA1 antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-TIA1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800657) Mouse IgG2b OTI1D7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TIA1 antibody

TA303222 (0.1µg/ml) staining of Jurkat cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TIA1 antibody

WB Suggested Anti-TIA1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: 721_B cell lysateTIA1 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TIA1 antibody

WB Suggested Anti-TIA1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human Thymus Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

TIA1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TIA1 (RC219386, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TIA1. Mouse IgG1 OTI2B1 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TIA1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TIA1 (RC219386, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TIA1. Mouse IgG1 OTI1A3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TIA1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TIA1 (RC219386, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TIA1. Mouse IgG2b OTIC3 Purified Hu WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

TIA1 antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-TIA1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800659) Mouse IgG1 OTI1C8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TIA1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TIA1 (RC219386, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TIA1. Mouse IgG1 OTI1C4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TIA1 (189-199) antibody

Immunohistochemistry Image: Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE). Goat Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Eq, Fi, Hst, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt, Tr, Xen E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TIA1 antibody

Formalin-Fixed, Paraffin-Embedded Human nasal T/NK cell lymphoma stained with TIA-1 antibody Cat.-No BM2703 using peroxidase conjugate and DAB chromogen. Note the cytoplasmic granular staining of lymphoma cells. Mouse IgG1 2G9A10F5 Purified Hu C, P
1 ml / €390.00
  Acris Antibodies GmbH

TIA1 antibody

TIA1 MaxPab polyclonal antibody. Western Blot analysis of TIA1 expression in human liver. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

TIA1 antibody

TIA1 MaxPab polyclonal antibody. Western Blot analysis of TIA1 expression in human liver. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

TIA1 antibody

Immunoprecipitation of TIA1 transfected lysate using anti-TIA1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with TIA1 MaxPab mouse polyclonal antibody (B01) (H00007072-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

TIA1 antibody

TIA1 polyclonal antibody ( Cat # PAB7257 ) ( 0.1 µg/ml ) staining of Jurkat cell lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

TIA1 antibody

Human 721_B; WB Suggested Anti-TIA1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: 721_B cell lysate. TIA1 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells.; TIA1 antibody - N-terminal region (ARP40979_P050) in Human 721_B cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

TIA1 antibody

Human Thymus; WB Suggested Anti-TIA1 Antibody Titration: 0.2-1 ug/ml. Positive Control: Human Thymus; TIA1 antibody - C-terminal region (ARP40981_P050) in Human Thymus cells using Western Blot Rabbit Aff - Purified Bov, Chk, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

TIA1 antibody

Western Blot: TIA1 Antibody [NB100-60555] - NB 100-60555 (0.1ug/ml) staining of Jurkat cell lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

TIA1 antibody

Western  Blot:  TIA1 Antibody [NBP1-33452] – Western blot analysis of TIA1 on 293T lysates using NBP1-33452 at a dilution of 1:1000. 30ug whole cell lysate loaded on 12% SDS PAGE gel. Rabbit IgG Hu ICC/IF, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TIA1 (transcript variant 2)

TIA1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

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