TIAM1 antibody

Principal name

TIAM1 antibody

Alternative names for TIAM1 antibody

TIAM-1, T-lymphoma invasion and metastasis-inducing protein 1

SwissProt ID

Q13009 (Human), Q60610 (Mouse)

Gene ID

7074 (TIAM1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of TIAM1 antibody

Directional cell migration is essential for various physiological processes such as embryonic development, angiogenesis, wound healing, and tumor invasion. In response to extracellular and cell adhesion signals, cells acquire a polarized morphology with a leading edge at their front and a trailing tail at the rear. This front-rear polarity is established along the directional axis, with signaling molecules, adhesions, and the cytoskeleton distributed asymmetrically. The signaling molecules that control polarity include the Rho family GTPases, including Rac1. The Rac exchange factor Tiam1 participates in polarized cell migration. Tiam1 binds to integrins through talin and regulates Rac1 activity and adhesion turnover for polarized migration. 
Tiam 1 contains a Dbl homology (DH) or RhoGEF domain which consists of an ~ 150 amino acid region that induces Rho family GTPases to displace GDP. This effectively activates the Rho GTPase by allowing GTP binding, which is in excess over GDP in the cell. The DH domain is invariably preceded by a pleckstrin homology (PH) domain. While not absolutely required for catalysis of nucleotide exchange, the PH domain appears to greatly increase catalytic efficiency in many cases. 
Tiam1 (T-cell lymphoma invasion and metastasis inducing protein 1) was originally identified as an invasion-inducing gene. Thereafter several studies supported the suggestion that the Tiam1-Rac signaling pathway may be involved in the invasion and metastasis of tumor cells.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TIAM1 antibody

TIAM1 Mouse IgG2b F5S F6.2 Purified Hu C, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

TIAM1 (1579-1591) antibody

Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Bear, Bov, Can, Chk, Eq, Hst, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt, Tr, Xen P
50 µg / €470.00
  Acris Antibodies GmbH

TIAM1 (904-1511) antibody

TIAM1 Rabbit IgG Aff - Purified Hu, Ms C, ICC/IF, IP, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

TIAM1 (80-183) antibody

TIAM1 Rabbit IgG Serum Hu, Ms C, ICC/IF, IP, P, WB
0.25 ml / €250.00
  Acris Antibodies GmbH

TIAM1 antibody

Western Blot: TIAM1 Antibody [NB100-2301] - Detection of Human and Mouse TIAM1 by Western Blot.  Samples: Whole cell lysate from NIH-3T3 (50 mcg) and Jurkat (25 mcg) cells.  Antibody: Affinity purified rabbit anti-TIAM1 antibody NB100-2301 used at 1 mcg/ml.  Detection:  Chemiluminescence with an exposure time of 2 minutes. Rabbit Aff - Purified Hu, Ms WB
0.1 mg / €440.00
  Novus Biologicals Inc.

TIAM1 antibody

TIAM1 Goat Purified Hu, Ms P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TIAM1

TIAM1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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