TIAM1 antibody

Principal name

TIAM1 antibody

Alternative names for TIAM1 antibody

TIAM-1, T-lymphoma invasion and metastasis-inducing protein 1

SwissProt ID

Q13009 (Human), Q60610 (Mouse)

Gene ID

7074 (TIAM1)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Eq (Equine), Hst (Hamster), Hu (Human), Mky (Monkey), Ms (Mouse), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Rt (Rat), Xen (Xenopus), Tr (Turkey), Bear

Available hosts

Goat, Mouse, Rabbit

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of TIAM1 antibody

Directional cell migration is essential for various physiological processes such as embryonic development, angiogenesis, wound healing, and tumor invasion. In response to extracellular and cell adhesion signals, cells acquire a polarized morphology with a leading edge at their front and a trailing tail at the rear. This front-rear polarity is established along the directional axis, with signaling molecules, adhesions, and the cytoskeleton distributed asymmetrically. The signaling molecules that control polarity include the Rho family GTPases, including Rac1. The Rac exchange factor Tiam1 participates in polarized cell migration. Tiam1 binds to integrins through talin and regulates Rac1 activity and adhesion turnover for polarized migration. 
Tiam 1 contains a Dbl homology (DH) or RhoGEF domain which consists of an ~ 150 amino acid region that induces Rho family GTPases to displace GDP. This effectively activates the Rho GTPase by allowing GTP binding, which is in excess over GDP in the cell. The DH domain is invariably preceded by a pleckstrin homology (PH) domain. While not absolutely required for catalysis of nucleotide exchange, the PH domain appears to greatly increase catalytic efficiency in many cases. 
Tiam1 (T-cell lymphoma invasion and metastasis inducing protein 1) was originally identified as an invasion-inducing gene. Thereafter several studies supported the suggestion that the Tiam1-Rac signaling pathway may be involved in the invasion and metastasis of tumor cells.

10 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TIAM1 antibody

TIAM1 Mouse IgG2b F5S F6.2 Purified Hu C, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

TIAM1 (904-1511) antibody

TIAM1 Rabbit IgG Aff - Purified Hu, Ms C, ICC/IF, IP, P, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

TIAM1 (80-183) antibody

TIAM1 Rabbit IgG Serum Hu, Ms C, ICC/IF, IP, P, WB
0.25 ml / €260.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

TIAM1 - human gene knockout kit via CRISPR

TIAM1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TIAM1 - human gene knockout kit via CRISPR

TIAM1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TIAM1 - human gene knockout kit via CRISPR

TIAM1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TIAM1 - human gene knockout kit via CRISPR

TIAM1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TIAM1

  Recombinant protein of human T-cell lymphoma invasion and metastasis 1 (TIAM1)  
TIAM1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, TIAM1 (mGFP-tagged) - Human T-cell lymphoma invasion and metastasis 1 (TIAM1), 200 uL, >10^7 TU/mL

Lenti ORF particles, TIAM1 (mGFP-tagged) - Human T-cell lymphoma invasion and metastasis 1 (TIAM1), 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, TIAM1 (Myc-DDK tagged) - Human T-cell lymphoma invasion and metastasis 1 (TIAM1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, TIAM1 (Myc-DDK tagged) - Human T-cell lymphoma invasion and metastasis 1 (TIAM1) , 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

10 Item(s)

per page
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