TIE1 antibody

Principal name

TIE1 antibody

Alternative names for TIE1 antibody

TIE, Tie-1, Tyrosine-protein kinase receptor Tie-1

SwissProt ID

P35590 (Human), Q06805 (Bovin), Q06806 (Mouse)

Gene ID

7075 (TIE1)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Rt (Rat)

Available hosts

Goat, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Immunoprecipitation (IP)

Background of TIE1 antibody

TIE1/TIE (tyrosine kinase with Ig and EGF homology domains 1) and TIE2/Tek define a new class of the receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin like domains flanking three epidermal growth factor (EFG) like domains followed by three fibronectin type III like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. Human TIE1 cDNA encodes a 1138 amino acid residue precursor protein with a putative signal peptide, an extracellular domain, and a cytoplasmic domain. Human TIE1/Fc, a disulfide linked homodimeric protein, has a calculated molecular mass of approximately 107 kDa. Due to glycosylation, the protein migrates to approximately 160 kDa in SDS PAGE under reducing conditions. TIE1 and TIE2, expressed primarily on endothelial and hematopoietic progenitor cells, play important roles in angiogenesis, vasculogenesis, and hematopoiesis. In developing vascular endothelial cells, TIE1 and TIE2 are specifically expressed. Two ligands that bind TIE have been identified, angiopoietin 1 and angiopoietin 2. Based on gene targeting studies, the in vivo functions of TIE1 are related to endothelial cell differentiation. The receptor tyrosine kinase TIE also plays a role in the survival and integrity of the endothelium.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TIE1 antibody

  Rabbit polyclonal anti-TIE1 antibody  
Western blot analysis of extracts from HepG2 cells, K562 cells and Jurkat cells, using TIE1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TIE1 antibody

  Rabbit Polyclonal anti-TIE-1 Antibody  
Human Tonsil stained with anti-TIE-1 antibody. Rabbit Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TIE1 antibody

  Rabbit Polyclonal TIE1 Antibody  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TIE1 (RC207771, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TIE1. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TIE1 antibody

Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 1G10 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

TIE1 (N-term) antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with TIE antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

TIE1 (C-term) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu P
50 µl / €470.00
  Acris Antibodies GmbH

TIE1 antibody

Western analysis of recombinant Human and Mouse sTIE-1 and sTIE-2 using a Polyclonal antibody directed against Mouse recombinant sTIE-1. There is a strong cross reactivity with Human sTIE-1 but only a weak one for Human and Mouse sTIE-2 visible. Rabbit IgG Purified Hu, Ms WB
0.2 mg / €370.00
  Acris Antibodies GmbH

TIE1 antibody

Western analysis of recombinant Human and Mouse sTIE-1 and sTIE-2 using a Polyclonal antibody directed against Mouse recombinant sTIE-1. There is a strong cross reactivity with Human sTIE-1 but only a weak one for Human and Mouse sTIE-2 visible. Rabbit IgG Purified Hu, Ms WB
0.1 mg / €270.00
  Acris Antibodies GmbH

TIE1 antibody

FACS analysis with primary human dermal microvascular endothelial cells (HDMVEC). Upper panel: no primary antibody; Middle panel: solely conjugated secondary antibody; Lower panel: Biotin-conjugated anti-Human TIE-1. Mouse IgG1 6F12 Biotin Hu E, F, WB
50 µg / €330.00
  Acris Antibodies GmbH

TIE1 antibody

TIE1 Mouse IgG1 6F12 Purified Hu E, F, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

TIE1 (Extracell. Dom.) antibody

TIE1 Mouse IgG1 8C9 Purified Hu E, F, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

TIE1 (Extracell. Dom.) antibody

Tie-1 staining of Paraffin-embedded tissue sections of human placenta were stained with anti-goat HRP-DAB (brown) and Haematoxylin (blue) counterstain. Goat Aff - Purified Hu E, P, WB
0.1 mg / €450.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

TIE1 - human gene knockout kit via CRISPR

TIE1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

TIE1 - human gene knockout kit via CRISPR

TIE1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TIE1 - human gene knockout kit via CRISPR

TIE1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TIE1 - human gene knockout kit via CRISPR

TIE1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

TIE1

  Recombinant protein of human tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE1)  
TIE1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

TIE1 (C-term DDK/His tag)

  Purified Recombinant protein of human tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE1), with C-terminal DDK/His tag, expressed in human cells, 20 µg  
TIE1 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

TIE1

  Recombinant protein of human tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE1)  
TIE1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €299.00
  OriGene Technologies, Inc.

TIE1 (C-term, His-tag)

TIE1 Mouse Purified > 90 % Insect cells
50 µg / €350.00
  Acris Antibodies GmbH

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