TIGAR antibody

Principal name

TIGAR antibody

Alternative names for TIGAR antibody

C12orf5, Probable fructose-2,6-bisphosphatase TIGAR, TP53-induced glycolysis and apoptosis regulator

SwissProt ID

Q1JQA7 (Bovin), Q8BZA9 (Mouse), Q9NQ88 (Human)

Gene ID

57103 (C12orf5), 5710309 (IPR014038)

Available reactivities

Hu (Human), Ms (Mouse), Chimp (Chimpanzee), Mky (Monkey), Rt (Rat), Bov (Bovine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Enzyme Immunoassay (E)

Background of TIGAR antibody

TIGAR (TP53-induced glycolysis and apoptosis regulator), a member of phosphoglycerate mutase family, is a target gene of p53 and it regulates glucose metabolism in cancer cells by acting as a fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate (Fru-2,6-P2 ) and Fru-1,6-P2 leading to decreased Fru-2,6-P2 levels with subsequent reduction in PFK1 (phosphofructosekise-1) activity as well as negative regulation of glycolysis. TIGAR also reduces cellular ROS through its translocation to the mitochondria where it interacts with HK2 leading to enhanced HK2 activity, regulation of mitochondrial membrane potential, and decreased mitochondrial ROS which ultimately protects the cells from D damage-induced apoptosis. Moreover, TIGAR mediated negative regulation of glycolysis leads to redirection of glycolytic metabolic intermediates towards pentose phosphate pathway's oxidative branch that follows increased cellular DPH production, ROS scavenging by GSH and thus a lower sensitivity of cells to oxidative stress-associated apoptosis, including that induced by p53. Because of TIGAR's anti-apoptotic/protective role, it has been proposed to implicate in cell-cycle arrest and D repair effector response in cells that suffer from repairable dose of genotoxic/cellular insult.

General readings

Bensaad K., et al. (2009) EMBO J. 28(19):3015-26.
Hasegawa H., et al. (2009) Leukemia. 23(11):2090-101.

Items 1 to 20 of 34 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TIGAR (Center) antibody

Western blot analysis of TIGAR in EL4 cell lysate with TIGAR antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TIGAR (Center) antibody

Immunofluorescence of TIGAR in Human Brain cells with TIGAR antibody at 20 ug/mL. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TIGAR antibody

Predicted cell location: Nucleus,Cytoplasm. Positive control: Human cervical and breast cancer tissue . Recommended dilution: 1/100-300  The image on the left is immunohistochemistry of paraffin-embedded human cervical cancer tissue using C12orf5 antibody at dilution 1/80, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TIGAR antibody

Western Blot: TIGAR Antibody [TA336787] - Analysis of TIGAR in HeLa whole cell extracts. Rabbit Purified Hu, Ms C, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TIGAR antibody

Breast: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TIGAR antibody

Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

TIGAR Control Peptide

TIGAR
50 µg / €160.00
  Acris Antibodies GmbH

TIGAR Control Peptide

TIGAR
50 µg / €160.00
  Acris Antibodies GmbH

TIGAR antibody

Western Blot analysis of C12orf5 expression in transfected 293T cell line (H00057103-T01) by C12orf5 MaxPab polyclonal antibody.

Lane 1: C12orf5 transfected lysate(29.7 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

TIGAR antibody

Western blot analysis of human C12orf5 in MCF-7 cell lysate in the 1 ) absence and 2 ) presence of immunizing peptide using C12orf5 polyclonal antibody ( Cat # PAB0309 ) at 2 µg/ml. Rabbit Chimp, Hu, Mky WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

TIGAR antibody

Immunohistochemistry of C12orf5 in human brain tissue with C12orf5 polyclonal antibody ( Cat # PAB13249 ) at 2.5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

TIGAR antibody

Immunohistochemistry of C12orf5 in human brain tissue with C12orf5 polyclonal antibody ( Cat # PAB13250 ) at 2.5 µg/ml. Rabbit Hu, Ms P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

TIGAR antibody

TIGAR Rabbit Aff - Purified Hu, Ms P, WB
0.1 ml / €360.00
  Novus Biologicals Inc.

TIGAR antibody

TIGAR Rabbit Aff - Purified Hu, Ms P, WB
0.1 ml / €390.00
  Novus Biologicals Inc.

TIGAR antibody

TIGAR Rabbit Aff - Purified Hu, Ms P, WB
0.1 ml / €390.00
  Novus Biologicals Inc.

TIGAR antibody

TIGAR Rabbit Aff - Purified Hu, Ms P, WB
0.1 ml / €390.00
  Novus Biologicals Inc.

TIGAR antibody

TIGAR Rabbit Aff - Purified Hu, Ms P, WB
0.1 ml / €390.00
  Novus Biologicals Inc.

TIGAR antibody

TIGAR Rabbit Aff - Purified Hu, Ms P, WB
25 µl / €160.00
  Novus Biologicals Inc.

TIGAR antibody

Immunohistochemistry-Paraffin: TIGAR Antibody [NBP1-76765] - TIGAR in human brain tissue with TIGAR antibody at 2.5 ug/ml. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

TIGAR antibody

Immunohistochemistry-Paraffin: TIGAR Antibody [NBP1-76766] - Human brain tissue with TIGAR antibody at 2.5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Items 1 to 20 of 34 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn