TIMP2 antibody

Principal name

TIMP2 antibody

Alternative names for TIMP2 antibody

CSC-21K, TIMP-2, Metalloproteinase inhibitor 2, Tissue inhibitor of metalloproteinases 2

SwissProt ID

O42146 (Chick), O77717 (Horse), P16035 (Human), P16368 (Bovin), P25785 (Mouse), P30121 (Rat), Q9TRZ7 (Rabit), Q9TTY1 (Canfa), Q9WUC6 (Cavpo)

Gene ID

7077 (TIMP2)

Available reactivities

Bov (Bovine), GP (Guinea Pig), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Por (Porcine), Chk (Chicken), Ze (Zebrafish), Mky (Monkey), Can (Canine), Eq (Equine)

Available hosts

Mouse, Sheep, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Flow Cytometry (F), Luminex (LMNX)

Background of TIMP2 antibody

Matrix metalloproteinases (MMPs) are a family of enzymes that are responsible for the degradation of extracellular matrix components such as collagen, laminin and proteoglycans. These enzymes are involved in normal physiological processes such as embryogenesis and tissue remodeling and may play an important role in arthritis, periodontitis, and metastasis.
The activation and activity of MMPs are regulated by a family of endogenous inhibitors, tissue inhibitors of metalloproteinase (TIMP).
TIMP2 (also called CSC-21K) is a 24 kDa glycoprotein that is expressed by a variety of cell types. It forms a non covalent, stoichiometric complex with both latent and active MMPs. TIMP2 shows a preference for MMP2. TIMPs are capable of altering the metastatic potential of cancer cells and have been shown to inhibit invasion and metastasis in animal models. TIMP2 is constitutively produced in low (pg/ml) levels by most cell types in tissue culture. The low protein levels produced often require concentration of cell culture media to visualize the bands by Western Blotting.

General readings

General / background references: Butler GS et al.; The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study. J Biol Chem 273:871-80 (1998). PubMed PMID: 9422744
Bramhall SR et al. Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma. J Pathol 182:347-55 (1997). PubMed PMID: 9349239
Hoyhtya M et al. Immunohistochemical localization of matrix metalloproteinase 2 and its specific inhibitor TIMP-2 in neoplastic tissues with monoclonal antibodies. Int J Cancer 56:500-5 (1994). PubMed PMID: 8112886
Visscher DW et al. Enhanced expression of tissue inhibitor of metalloproteinase-2 (TIMP-2) in the stroma of breast carcinomas correlates with tumor recurrence. Int J Cancer 59:339-44 (1994). PubMed PMID: 7927938

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TIMP2 antibody

Western blot analysis of recombinant human TIMP-2 protein using anti-TIMP-2, clone F27P3A4. Mouse IgG2a F27P3A4 Purified Chk, Hu, Ms, Por, Rb, Ze E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

TIMP2 antibody

Staing of gastric carcinoma using TIMP-1 and TIMP-2 (AF7010) antibodies Mouse IgG1 67-4H11 Purified Bov, GP, Hu, Ms, Rb, Rt C, E, P, WB
0.1 mg / €300.00
  Acris Antibodies GmbH

TIMP2 antibody

Western blot analysis of recombinant human TIMP-2 protein using anti-TIMP-2, clone F27P3A4. Mouse IgG2a F27P3A4 Purified Chk, Hu, Ms, Por, Rb, Ze E, P, WB
25 µg / €220.00
  Acris Antibodies GmbH

TIMP2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-TIMP2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504017) Mouse IgG1 OTI1A6 Purified Can, Hu, Mky, Ms, Rt F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TIMP2 antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-TIMP2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504018) Mouse IgG1 OTI2G7 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TIMP2 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-TIMP2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504043) Mouse IgG1 OTI1D7 Purified Can, Hu, Mky, Ms, Rt F, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

TIMP2 antibody

Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-TIMP2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504044) Mouse IgG1 OTI1B11 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

TIMP2 antibody

TIMP2 Elisa with 1A6 Capture (TA600235) and 2G7 Detection (TA700235) Antibodies. Substrate used: Recombinant Human TIMP2 (TP309796) Mouse IgG1 OTI1A6 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

TIMP2 antibody

TIMP2 Luminex Elisa with 3H8 Capture (TA600236) and 1A6 Detection (TA700243) Antibodies. Substrate used: Recombinant Human TIMP2 (TP309796) Mouse IgG1 OTI3H8 Purified Hu LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

TIMP2 antibody

TIMP2 Elisa with 3G7 Capture (TA600238) and 1A6 Detection (TA700243) Antibodies. Substrate used: Recombinant Human TIMP2 (TP309796) Mouse IgG1 OTI3G7 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

TIMP2 antibody

TIMP2 Elisa with 1A6 Capture (TA600235) and 2G7 Detection (TA700235) Antibodies. Substrate used: Recombinant Human TIMP2 (TP309796) Mouse IgG1 OTI2G7 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

TIMP2 antibody

TIMP2 Elisa with 1A6 Capture (TA600235) and 1B11 Detection (TA700237) Antibodies. Substrate used: Recombinant Human TIMP2 (TP309796) Mouse IgG1 OTI3H8 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

TIMP2 antibody

TIMP2 Elisa with 1A6 Capture (TA600235) and 1C4 Detection (TA700242) Antibodies. Substrate used: Recombinant Human TIMP2 (TP309796) Mouse IgG1 OTI1B11 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

TIMP2 antibody

TIMP2 Elisa with 3G7 Capture (TA600238) and 3H8 Detection (TA700236) Antibodies. Substrate used: Recombinant Human TIMP2 (TP309796) Mouse IgG1 OTI1C4 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

TIMP2 antibody

TIMP2 Elisa with 3G7 Capture (TA600238) and 1C4 Detection (TA700242) Antibodies. Substrate used: Recombinant Human TIMP2 (TP309796) Mouse IgG1 OTI1A6 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

TIMP2 antibody

Colon carcinoma stained with Anti-TIMP-2 antibody Rabbit Purified Hu P, WB
1 ml / €440.00
  Acris Antibodies GmbH

TIMP2 antibody

Colon carcinoma stained with Anti-TIMP-2 antibody Rabbit Purified Hu P, WB

Regular Price: 0.1 ml / €180.00

Special Price: 0.1 ml / €98.00

  Acris Antibodies GmbH

TIMP2 antibody

Western blot analysis of extracts from A549 cells, using TIMP2 antibody (#TA313021).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TIMP2 antibody

Predicted cell location: Cytoplasm. Positive control: Human liver and gastric cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using TIMP2 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TIMP2 antibody

Western blot analysis of TIMP2 expression in A549 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

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